Serum concentrations of antioxidant vitamins and carotenoids are low in individuals with a history of attempted suicide

Li, Yanfeng; Zhang, Jian

doi:10.1080/10284150701250747

Cited by 38 publications

(29 citation statements)

References 49 publications

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“…Although the evidence to date is preliminary, levels of antioxidants, vitamins, and carotenoids have also been found to be lower in patients with a history of suicide attempts (Li et al , 2007). Investigators have speculated that lowered antioxidant capacity may impair protection against ROS, thus damaging fatty acids (Edwards et al , 1998, Maes et al , 1999).…”

Section: Oxidative Stress Cholesterol and ω3 Fatty Acids In The Patmentioning

confidence: 99%

“…Therefore, it is important to prevent depressive episodes due to vitamin/mineral deficiency, particularly for people under high levels of stress. The role of nutrients in the treatment of depression and suicidal behaviors has been extensively studied in the civilian population (Cocchi et al , 1980, Papakostas et al , 2005, Enya et al , 2004, Li and Zhang, 2007, Sowa-Kucma et al , 2008). Whether or not the nutrients may help as a strategy for the prevention or adjunctive treatment of depression or suicidal ideation in the military and civilian population remains underexplored.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

Zhu

Bao

et al. 2014

Critical Reviews in Food Science and Nutrition

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Numerous studies have linked severe stress to the development of major depressive disorder (MDD), and suicidal behaviors. Furthermore, recent preclinical studies from our laboratory and others have demonstrated that in rodents, chronic stress and the stress hormone cortisol has caused oxidative damage to mitochondrial function and membrane lipids in the brain. Mitochondria play a key role in synaptic neurotransmitter signaling by providing adenosine triphosphate (ATP), mediating lipid and protein synthesis, buffering intracellular calcium, and regulating apoptotic and resilience pathways. Membrane lipids are similarly essential to central nervous system (CNS) function, because cholesterol, polyunsaturated fatty acids, and sphingolipids form a lipid raft region, a special lipid region on the membrane that mediates neurotransmitter signaling through G-protein coupled receptors and ion channels. Low serum cholesterol levels, low antioxidant capacity, and abnormal early morning cortisol levels are biomarkers consistently associated with both depression and suicidal behaviors. In this review, we summarize the manner in which nutrients can protect against oxidative damage to mitochondria and lipids in the neuronal circuits associated with cognitive and affective behaviors. These nutrients include ω3 fatty acids, antioxidants (vitamin C and zinc), members of the vitamin B family (Vitamin B12 and folic acid) and magnesium. Accumulating data have shown that these nutrients can enhance neurocognitive function, and may have therapeutic benefits for depression and suicidal behaviors. A growing body of studies suggests the intriguing possibility that regular consumption of these nutrients may help prevent the onset of mood disorders and suicidal behaviors in vulnerable individuals, or significantly augment the therapeutic effect of available antidepressants. These findings have important implications for the health of both military and civilian populations.

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Section: Oxidative Stress Cholesterol and ω3 Fatty Acids In The Patmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

Zhu

Bao

et al. 2014

Critical Reviews in Food Science and Nutrition

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“…Low serum levels of lycopene have also been associated with increased risk of psychiatric disorders (Li & Zhang 2007). A cross-sectional study using NHANES III data (n = 6680) observed an inverse association between serum levels of certain vitamins and carotenoids and whether subjects had attempted suicide (Li & Zhang 2007).…”

Section: Potential Health Benefits Of Lycopenementioning

confidence: 99%

“…A cross-sectional study using NHANES III data (n = 6680) observed an inverse association between serum levels of certain vitamins and carotenoids and whether subjects had attempted suicide (Li & Zhang 2007). Suicide attempters had lower levels of antioxidant vitamins and carotenoids in their serum than did nonattempters.…”

Section: Potential Health Benefits Of Lycopenementioning

confidence: 99%

An Update on the Health Effects of Tomato Lycopene

Story

Kopec

Schwartz

et al. 2010

Annu. Rev. Food Sci. Technol.

356

226

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Lycopene is a non-provitamin A carotenoid that is responsible for the red to pink colors seen in tomatoes, pink grapefruit, and other foods. Processed tomato products are the primary dietary lycopene source in the United States. Unlike many other natural compounds, lycopene is generally stable to processing when present in the plant tissue matrix. Recently, lycopene has also been studied in relation to its potential health effects. Although promising data from epidemiological, as well as cell culture and animal, studies suggest that lycopene and the consumption of lycopene containing foods may affect cancer or cardiovascular disease risk, more clinical trial data is needed to support this hypothesis. In addition, future studies are required to understand the mechanism(s) whereby lycopene or its metabolites are proven to possess biological activity in humans.

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“…116 Low serum levels of lycopene have also been associated with increased risk of psychiatric disorders. 117 A study with 17 adults with asthma treated with placebo, tomato extract (Lyc-o-Mato ® , 45 mg/day lycopene), and tomato juice (45 mg/day of lycopene) for 7 days showed reduced airway neutrophil influx and reduced sputum neutrophil elastase activity after the tomato extract and tomato juice treatment. During placebo treatment, plasma lycopene concentrations decreased, the percentage of neutrophils increased, and neutrophil elastase levels increased.…”

Section: Other Diseasesmentioning

confidence: 99%

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

Bacanlı¹,

Başaran²,

Başaran³

2017

tjps

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It is well known that free oxygen radicals play an important role in the pathogenesis of several chronic disorders. Antioxidants are known as potential scavengers of reactive oxygen species that can protect biologic membranes against oxidative damage. Recent interest in phytochemicals has increased because of their protective effects against free oxygen radicals. Lycopene, which belongs to the carotenoid family, is the most effective singlet oxygen scavenger in vitro of all the carotenoids. Foods that contain lycopene and related supplements have been reported to prevent chronic diseases including cancer, asthma, and cardiovascular disorders. The aim of the article was to give a brief review of the antioxidant properties and beneficial health effects of lycopene.

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Serum concentrations of antioxidant vitamins and carotenoids are low in individuals with a history of attempted suicide

Abstract: A history of attempted suicide is associated with low levels of antioxidant vitamins and carotenoids. Clinical importance of low antioxidants in attempters and interventional opportunity warrant further examination.

Cited by 38 publications

References 49 publications

The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

An Update on the Health Effects of Tomato Lycopene

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

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