Serum concentrations of flurbiprofen in rheumatoid patients receiving flurbiprofen over long periods of time

Cardoe, N; DeSilva, Malini B.; Glass, R. C.; Risdall, P. C.

doi:10.1185/03007997709108971

Cited by 20 publications

(8 citation statements)

References 2 publications

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“…In the present study, the mean plasma concentration was 3331 ng ml -1 in the patients receiving orally administered flurbiprofen. This result is comparable with the previous data [9,[11][12][13][14]. Concerning topical application with the same two tapes as used in the present study, it was reported that the Cmax in the plasma was 870 ng ml -1 at the tmax of 11.6 h [8].These data are also comparable with the present result (1369 ng ml -1 ) on the plasma concentration in the patients receiving topically applied flurbiprofen.…”

Section: Discussionsupporting

confidence: 83%

“…After oral administration of a tablet containing 40 mg flurbiprofen, the Cmax in the plasma was 5600 ng ml -1 and the tmax was 1.4 h [9]. After oral administration of a tablet containing 50 mg flurbiprofen, several studies reported that the Cmax ranged from 4200 to 8200 ng ml -1 and that the tmax ranged from 1.3 to 2.8 h [11][12][13][14]. In the present study, the mean plasma concentration was 3331 ng ml -1 in the patients receiving orally administered flurbiprofen.…”

Section: Discussionmentioning

confidence: 99%

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Flurbiprofen concentration in soft tissues is higher after topical application than after oral administration

Kai

Kondo

Kawaguchi

et al. 2013

Brit J Clinical Pharma

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AIMTo compare tissue concentrations of flurbiprofen resulting from topical application and oral administration according to the regulatory approved dosing guidelines. METHODSixteen patients were included in this study. Each patient was randomly assigned to the topical application or oral administration group. In each group, a pair of tapes or a tablet, containing a total of 40 mg flurbiprofen, was administered twice at 16 and 2 h before the surgery. RESULTSThe flurbiprofen concentration in the fat, tendon, muscle and periosteum tissues was significantly higher (P < 0.0330) after topical application (992 ng CONCLUSIONTopical application is an effective method to deliver flurbiprofen to the human body, particularly to soft tissues near the body surface.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Flurbiprofen concentration in soft tissues is higher after topical application than after oral administration

Kai

Kondo

Kawaguchi

et al. 2013

Brit J Clinical Pharma

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“…The elimination half-life of flurbiprofen is 3 to 4 hours and does not seem to be significantly different following long term administration (Adams et aI., 1973;Cardoe et al, 1977).…”

Section: Eliminationmentioning

confidence: 97%

Clinical Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs

Verbeeck

Blackburn

Loewen

1983

Clinical Pharmacokinetics

214

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The number of non-steroidal anti-inflammatory drugs (NSAIDs) available for clinical use has dramatically increased during the last decade. As a general rule, NSAIDs are well absorbed from the gastrointestinal tract, with the exception of aspirin (and possibly diclofenac, tolfenamic acid and fenbufen) which undergoes presystemic hydrolysis to form salicylic acid. Concomitant administration of NSAIDs with food or antacids may in some cases lead to delayed or even reduced absorption. The NSAIDs are highly bound to plasma proteins (mainly albumin), which limits their body distribution to the extracellular spaces. Apparent volumes of distribution of NSAIDs are, therefore, very low and usually less than 0.2 L/kg. The elimination of these drugs depends largely on hepatic biotransformation; renal excretion of unchanged drugs is usually small (less than 5% of the dose). Total body clearance is low and for most NSAIDs is less than 200 ml/min. The effect of age and disease on the disposition of NSAIDs has not been extensively studied. Due to the central role of the liver in the overall elimination of the majority of these compounds, hepatic disease will most likely lead to a significant alteration in their pharmacokinetic behaviour. NSAIDs have been reported to be involved in numerous pharmacokinetic drug interactions. Aspirin decreases the plasma concentrations of many other NSAIDs, although the clinical significance of this is uncertain. Due to the extremely high plasma protein binding of NSAIDs (around 99% in many cases), competition for the same binding sites on plasma proteins may be at least partly responsible for some interactions of NSAIDs with other highly bound drugs; however, another mechanism such as decreased metabolism or decreased urinary elimination is usually involved as well. The most important interactions with NSAIDs are those involving the oral anticoagulants and oral hypoglycaemic agents, though not all NSAIDs have been found to interact with these drugs. In clinical practice, there appear to be no clear-cut guidelines to assist the clinician in the selection of the most appropriate drug for an individual patient. The selection of an anti-inflammatory drug should be based on clinical experience, patient convenience (e.g. once or twice daily dosage schedule), side effects and cost. Since a marked interindividual variability exists in the clinical response to a given NSAID, clinicians prescribing these agents may try several of them sequentially until an adequate response is obtained.

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“…Intraday preci- Table 3 Regression equations, limits of detection (LOD), and limits of quantitation (LOQ) for six NSAIDs in human plasma using the present method a Data given as mean ± SD calibration are summarized in Table 6. These concentrations in plasma were within therapeutic levels [22,[30][31][32][33][34].…”

Section: Validation Of the Methodsmentioning

confidence: 99%

“…The LOD values of all drugs under optimal conditions were 0.002-0.005 μg/ml; the LOQ values were 0.01-0.02 μg/ml. The therapeutic levels of NSAIDs were reported to be 16.1 μg/ml for alminoprofen [30], 11.3 μg/ml for zaltoprofen [22], 15.3-53 μg/ml for tiaprofenic acid [31], 4.45 μg/ml for pranoprofen [32], 17-49 μg/ml for ibuprofen [33], and 8.2-14.6 μg/ml for fl urbiprofen [34]. Therefore, our present method is sensitive enough to analyze their therapeutic levels.…”

Section: Validation Of the Methodsmentioning

confidence: 99%

Determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS-MS with a hydrophilic polymer column

et al. 2010

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showed excellent linearity in the range of 0.01-25 μg/ml of plasma, and limits of detection were in the range of 0.002-0.005 μg/ml. Limits of quantitation were 0.01-0.02 μg/ml. Intraday and interday coeffi cients of variation for all drugs in plasma were not greater than 8.1%. The accuracy of quantitating the six drugs was in the range of 94.5%-110%. Data obtained from actual determinations of the levels of alminoprofen, pranoprofen, and ibuprofen in human plasma after oral administration are also presented.

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Serum concentrations of flurbiprofen in rheumatoid patients receiving flurbiprofen over long periods of time

Cited by 20 publications

References 2 publications

Flurbiprofen concentration in soft tissues is higher after topical application than after oral administration

Flurbiprofen concentration in soft tissues is higher after topical application than after oral administration

Clinical Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs

Determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS-MS with a hydrophilic polymer column

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