Serum Concentrations of Haptoglobin and Hemopexin in Favism and Thalassemia

Cutillo, S; Meloni, T

doi:10.1159/000208222

Cited by 13 publications

(2 citation statements)

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“…The indirect signs of haemolysis (levels of dehydroge nases and haptoglobin) confirm that moderate haemolysis was occurring in our patients [29], The data on reticulo cytes, haptoglobin, LDH and BDH are quite interesting: although the differences between the G6PD-deficient and control group were small, this set of results constitutes some of the best available documentation of low-grade haemolysis during the steady state in G6PD-deficient sub jects.…”

Section: Discussionsupporting

confidence: 82%

Low-Grade Haemolysis and Assessment of Iron Status during the Steady State in G6PD-Deficient Subjects

Ragusa

Cataldo²,

Gangarossa³

et al. 1993

Acta Haematol

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We evaluated the iron status of 50 Sicilian patients with un-G6PD deficiency der steady-state conditions and compared our results with those for 50 control patients. We studied haemolysis and iron indices to evaluate the iron balance. These patients could be considered to be at risk of iron overload as a result of increased bone marrow activity. Reticulocytosis and macrocytosis with reduced levels of haptoglobin were found in the G6PD-deficient subjects, both of which are evidence of a moderate haemolysis. Iron status within the normal range, without iron overload or iron deficiency, was found.

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Section: Discussionsupporting

confidence: 82%

Low-Grade Haemolysis and Assessment of Iron Status during the Steady State in G6PD-Deficient Subjects

Ragusa

Cataldo²,

Gangarossa³

et al. 1993

Acta Haematol

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“…Cutillo et al 19) demonstrated that out of 45 thalassemia major cases, Hp level was absent (Hp 0) in 13 subjects and Hx level was also absent (Hx 0) in 37 subjects. It has been stated that Hx depletion depends on the high concentration of free heme and decreased or absent of Hx also leads to very severe hemolysis.…”

Section: Groupsmentioning

confidence: 99%

Effects of α-tocopherol on hemolysis and oxidative stress markers on red blood cells in β-thalassemia major

et al. 2020

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Background: The accumulation of unpaired α-globin chains in patients with β-thalassemia major may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia. Multiple blood transfusions and iron overload cause cellular oxidative damage. However, α-tocopherol, an antioxidant, is a potent scavenger of lipid radicals in the membranes of red blood cells (RBCs) of patients with β-thalassemia major.Purpose: To evaluate the effects of α-tocopherol on hemolysis and oxidative stress markers on the RBC membranes of patients with β-thalassemia major.Methods: Forty subjects included in this randomized controlled trial were allocated to the placebo and α-tocopherol groups. Doses of α-tocopherol were based on Institute of Medicine recommendations: 4–8 years old, 200 mg/day; 9–13 years old, 400 mg/day; 14–18 years old, 600 mg/day. Hemolysis, oxidative stress, and antioxidant variables were evaluated before and after 4-week α-tocopherol or placebo treatment, performed before blood transfusions.Results: Significant enhancements in plasma haptoglobin were noted in the α-tocopherol group (3.01 mg/dL; range, 0.60–42.42 mg/dL; <i>P</i>=0.021). However, there was no significant intergroup difference in osmotic fragility test results; hemopexin, malondialdehyde, reduced glutathione (GSH), or oxidized glutathione (GSSG) levels; or GSH/GSSG ratio.Conclusion: Use of α-tocopherol could indirectly improve hemolysis and haptoglobin levels. However, it played no significant role in oxidative stress or as an endogen antioxidant marker in β-thalassemia major.

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2001

The Thalassaemia Syndromes

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Serum Concentrations of Haptoglobin and Hemopexin in Favism and Thalassemia

Cited by 13 publications

References 4 publications

Low-Grade Haemolysis and Assessment of Iron Status during the Steady State in G6PD-Deficient Subjects

Low-Grade Haemolysis and Assessment of Iron Status during the Steady State in G6PD-Deficient Subjects

Effects of α-tocopherol on hemolysis and oxidative stress markers on red blood cells in β-thalassemia major

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