Serum concentrations of laminin and aminoterminal propeptide of type III procollagen in relation to the portal venous pressure of fibrotic liver diseases

Gressner, A. M.; Tittor, W; Negwer, A.; Pick-Kober, K.-H.

doi:10.1016/0009-8981(86)90008-2

Cited by 55 publications

(26 citation statements)

References 35 publications

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“…In accordance with this hypothesis it is shown in the present study that the mean concentrations of laminin and procollagen peptide in the serum of the liver outflow vascular region are respectively 9.5% and 37.2%, higher than those in a peripheral vein. Similar regional differences in the concentrations of these proteins were also observed in a preliminary study with a limited number of patients (23). Assuming liver inflow concentrations (similar in portal vein and hepatic artery) of laminin and procollagen peptide identical with those measured in the systemic circulation, we conclude from these data that the fibrosing liver secretes a significant fraction of serum laminin and procollagen peptide.…”

Section: Discussionsupporting

confidence: 76%

Estimation of the Production Rates of Serum Aminoterminal Propeptide of Type III Procollagen and Laminin in Human Fibrotic Liver

Gressner

Kropf²,

Tittor³

1987

Clinical Chemistry and Laboratory Medicine

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The concentrations of laminin, a high molecular weight non-collagenous glycoprotein of basement membranes, and of the N-terminal propeptide of type III procollagen were determined in the senim of the liver outflow vascular region (hepatic vein) and of a peripheral vein (cubital vein) in patients with chronic liver diseases (fibrosis, cirrhosis, unspecified histology; n = 173), in order to determine their secretion rates from the injured livers. The mean levels of laminin (1.84 kU/1) and of procollagen peptide (28.0 g/l) in hepatic vein were significantly higher (about 9.5% at p < 0.02, and 37% at p < 0.001, respectively) than those in the periphery (1.68 kU/1 and 20.4 g/l, respectively). In chronic liver diseases, however, laminin and procollagen peptide concentrations in the hepatic vein were lower than or equal to those in the cubital vein in 18% and 27% of patients, respectively. The highest regional differences of the concentrations were noted in cirrhotic sübjects. The seruin levels of laminin (r s 0.93) and of procollagen peptide (r s 0.73) in hepatic and in cubital vein are highly positively correlated (p < 0.001), but the levels of procollagen peptide in hepatic vein are only weakly but still significantly statistically related with those of laminin (r s 0.446, p < 0.001). Similarly, the hepatic-cubital venous concentration differences of both proteins are weakly (r s 0.312) but significantly (p < 0.001) correlated. On the basis of several assumptions we estimated secretion rates from the livers of 120 U · min" 1 för laminin, and 5.7 g · min" 1 for procollagen peptide. These data support the view that the chronically injured human liver is highly active in producing serum laminin and procollagen peptide, which are measured in elevated concentrations in the senim of liver fibrotic and cirrhotic sübjects. The resülts point to a high turnoVer of these connective tissue-derived proteins in the circulation.is accomplished by a stimulated production in various Fibrosis, a inain histological featüre of liver eirrhosis, parenchymal and non-parenchymal types of liver is characterized biochemically by several fold in-cells, but the mechanisms of enhanced synthesis are creases of the ainounts and changes of the molecular only pporly understood (2). Along with the developcomposition of various types of eollagens ( , III, ment of liver fibrosis, the concentrations of some IV, V, VI), noncollagenous (structural) glycoproteins connective tissue-derived proteins or their cleavage (fibrpnectin, laminin), proteoglycans (heparan sul-products increase in serum, an observation which has phate, chondroitiü sulphate, dennatan sulphate), and been exploited for clinical chemical diagnosis and glycosaminoglycans (hyaluronic acid) iti the extracel-follow-up of fibrogenesis (3, 4). Among these paralular space of the liver tissue (1). Their accumulation .meters, the determination of the concentration of the

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Section: Discussionsupporting

confidence: 76%

Estimation of the Production Rates of Serum Aminoterminal Propeptide of Type III Procollagen and Laminin in Human Fibrotic Liver

Gressner

Kropf²,

Tittor³

1987

Clinical Chemistry and Laboratory Medicine

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“…Conventionally, serum laminin level is thought to be a useful marker for evaluating the degree of hepatic fibrosis and portal pressure in view of the biological function of laminin [18,19,[29][30][31][32][33]. However, studies showed that laminin is involved in regulating immune responses via various pathways [23][24][25][26]34].…”

Section: Discussionmentioning

confidence: 99%

Higher pretherapy and significant decrease during the first 12 months of therapy in serum laminin levels may associate with hepatitis B e antigen seroconversion in chronic hepatitis B patients treated with lamivudine

et al. 2010

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Laminin participates in regulating immune response in addition to being a biomarker of liver fibrosis. Lamivudine has been shown to be able to restore cytotoxic T-cell response in chronic hepatitis B. In this study, fifty-two patients with HBeAg-positive chronic hepatitis B received lamivudine treatment for more than 12 months. Serum laminin levels were determined at baseline and during treatment and analyzed regarding treatment responses at the end of 12 months of therapy. The results showed that laminin levels at 12 months of treatment in patients who lost HBeAg were significantly lower compared with baseline (P = 0.001). The baseline laminin levels were higher in HBeAg seroconversion group than those without seroconversion (P = 0.037). Compared with baseline, the levels of serum laminin in HBeAg seroconversion group showed significant decrease (P = 0.001). It is concluded that higher pretherapy and significant decrease during the first 12 months of therapy in laminin levels may associate with HBeAg seroconversion in chronic hepatitis B patients treated with lamivudine, indicating the possible novel information of laminin for clinical reference.

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“…Furthermore, soluble laminin binds to s. aureus but not to S. epidermidis, and a tentative receptor of S. aureus for laminin has been described [7]. Laminin is present in the serum of healthy persons in a concentration of 1"\.10.2 J,1g/mL, and the serum concentration of laminin is increased in the presence of liver diseases [52]. We found that adherence was promoted for four of eight S. aureus strains, whereas adherence of all the tested coagulase-negative strains was uniformly weak.…”

Section: Herrmann Et Afmentioning

confidence: 99%

Fibronectin, Fibrinogen, and Laminin Act as Mediators of Adherence of Clinical Staphylococcal Isolates to Foreign Material

Herrmann

Vaudaux²,

Pittet³

et al. 1988

The Journal of Infectious Diseases

494

269

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Bacterial adherence to polymer surfaces is a required early step in intravenous (iv) device infection. Wecollected eight strains of Staphylococcus aureus and 19of coagulase-negative staphylococci from patients with proven iv device bacteremia and studied the role of plasma or connective-tissue proteins in promoting bacterial adherence to polymethylmethacrylate (PMMA) coverslips. Although only a negligible percentage of organisms adhered to albumin-coated PMMA, surface-bound fibronectin significantly promoted adherence of all isolates. Fibrinogen markedly promoted adherence of all S. aureus strains but of only four coagulase-negative strains. Thus, coagulase-negative staphylococci revealed a marked heterogeneity in adherence to fibrinogen-coated surfaces, a result suggesting the existence of heretofore unknown receptors for fibrinogen. Laminin promoted adherence of staphylococci to a much lower extent. Although strain specific, adherence of clinical staphylococcal isolates to foreign surfaces is significantly increased by fibronectin, fibrinogen, and laminin, an observation suggesting the possible contribution of these proteins to the pathogenesis of iv device infection.Adherence of microorganisms to specific substrates is presently considered to be a crucial step in the initiation of infections [1]. Many investigators have searched for such ligands in staphylococcal prosthesis infection. There is increasing evidence that similar specific interactions might also playa role in the pathogenesis of foreign-body infections.After contact with blood, a polymer surface (such as a cannula inserted iv) is almost immediately coated with a protein layer at the blood-polymer interface [2][3][4]. Bacterial adherence to the protein-coated surface is a prerequisite for initiating iv device infection. Fibrinogen and fibronectin are proteins known to bind and to aggregate staphylococci [5,6]. More recently, laminin, a large glycoprotein mainly found Receivedfor publication 2 December 1987and in revised form 7 April 1988. This paper was presented in part at the 27th Interscience Conference on Antimicrobial Agents and Chemotherapy (abstract 503), held on 4-7 October 1987, in New York, New York.This work was supported by grant 3.829-0.87 from the Swiss National Research Foundation.We thank Elzbieta Huggler for technical assistance, Dr. Ingeborg Filthuth and Chantal Genier for isolation and characterization of the bacterial isolates, and Paule Schilling-Doriot for manuscript preparation.Please address requests for reprints to Dr. Mathias Herrmann, Infectious Diseases Division, Department of Medicine, University Hospital, CH-1211 Geneva 4, Switzerland. 693in basal membranes and to a slight extent in plasma, has also been described as possessing staphylococcalbinding properties [7]. Several studies have investigated staphylococcal adherence [8][9][10][11] to polymer surfaces. In particular, studies performed on explanted foreign bodies [12,13]and on in vitro models [14,15]strongly suggested that adherence of selected staphylococcal str...

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Serum concentrations of laminin and aminoterminal propeptide of type III procollagen in relation to the portal venous pressure of fibrotic liver diseases

Cited by 55 publications

References 35 publications

Estimation of the Production Rates of Serum Aminoterminal Propeptide of Type III Procollagen and Laminin in Human Fibrotic Liver

Estimation of the Production Rates of Serum Aminoterminal Propeptide of Type III Procollagen and Laminin in Human Fibrotic Liver

Higher pretherapy and significant decrease during the first 12 months of therapy in serum laminin levels may associate with hepatitis B e antigen seroconversion in chronic hepatitis B patients treated with lamivudine

Fibronectin, Fibrinogen, and Laminin Act as Mediators of Adherence of Clinical Staphylococcal Isolates to Foreign Material

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