Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage

Tong, Stephen; Marjono, Budi; Brown, David A.; Mulvey, Sheila; Breit, Samuel N.; Manuelpillai, Ursula; Wallace, Euan M.

doi:10.1016/s0140-6736(03)15265-8

Cited by 97 publications

(80 citation statements)

References 5 publications

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“…GDF15 has a broad activity, as indicated by the diversity of the nomenclature (MIC-1, PTGF-b, PLAB, PDF, NAG-1, and PL74). In healthy subjects, GDF15 is highly expressed in the placenta, with serum concentration increasing during pregnancy (24,25). GDF15 concentration is notably increased in the serum of patients with glioma, prostate, colorectal, or pancreatic cancer (26)(27)(28)(29), and the factor was recently described as belonging to a series of 20 biomarkers that best define the malignant phenotype of numerous tumors (30).…”

Section: Introductionmentioning

confidence: 99%

Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma

et al. 2012

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Overexpression of growth differentiation factor 15 (GDF15) by bone marrow mesenchymal stem cells occurs widely in patients with multiple myeloma, but the pathophysiologic effects of GDF15 in this setting remain undefined. GDF15 has been described in numerous solid tumors but never in hematologic malignancies. In this study, we report that GDF15 significantly increases survival of stroma-dependent multiple myeloma cells including primary multiple myeloma cells. In particular, GDF15 conferred resistance to melphalan, bortezomib, and to a lesser extent, lenalidomide in both stroma-dependent and stroma-independent multiple myeloma cells. Akt-dependent signaling was critical to mediate the effects of GDF15, whereas Src and extracellular signalregulated kinase 1/2 signaling pathways were not involved. Given these results, we tested the clinical significance of plasma concentrations of GDF15 (pGDF15) in 131 patients with multiple myeloma and found that it correlated with disease prognosis. Specifically, patients with high levels of pGDF15 had lower probabilities of event-free and overall survival 30 months after diagnosis than patients with low pGDF15 levels. Our findings suggest that tumor microenvironment-derived GDF15 is a key survival and chemoprotective factor for multiple myeloma cells, which is pathophysiologically linked to both initial parameters of the disease as well as patient survival.

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Section: Introductionmentioning

confidence: 99%

Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma

et al. 2012

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“…However, much higher levels of GDF-15 are found in placenta (21), where it may help to prevent miscarriage (22). Additionally, GDF-15 overexpression has been described in numerous malignancies, including breast, colorectal, pancreatic, and prostate cancer (23,24).…”

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confidence: 99%

GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas

Roth

Junker

Tritschler

et al. 2010

Clinical Cancer Research

146

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Purpose: Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-β family. GDF-15 is necessary for the maintenance of pregnancy but has also been linked to other physiologic and pathologic conditions.Experimental Design: The expression of GDF-15 in glioma cell lines was assessed by quantitative reverse transcriptase-PCR and immunoblot. GDF-15 levels in situ and in the peripheral blood of glioma patients were examined by immunohistochemistry and enzyme-linked immunosorbent assay, respectively. The effects of short hairpin RNA-mediated GDF-15 inhibition on proliferation and immunogenicity of SMA-560 glioma cells were investigated by [methyl-3

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“…Serum GDF15 concentrations have been found to increase during pregnancy (19 ), and low GDF15 concentrations reportedly are associated with an increased risk of miscarriage (20 ). Additional studies have shown that patients with pancreatic and colorectal cancer may present with increased circulating GDF15 concentrations (21)(22)(23).…”

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confidence: 99%

Circulating Concentrations of Growth-Differentiation Factor 15 in Apparently Healthy Elderly Individuals and Patients with Chronic Heart Failure as Assessed by a New Immunoradiometric Sandwich Assay

et al. 2007

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Background: Growth-differentiation factor 15 (GDF15) is a member of the transforming growth factor ␤ (TGF-␤) cytokine superfamily. There has been increasing interest in using circulating GDF15 as a biomarker in patients, for example those with cardiovascular disease. Methods: We developed an IRMA that uses a polyclonal, affinity chromatography-purified goat antihuman GDF15 IgG antibody, assessed the preanalytic characteristics of GDF15, and determined circulating GDF15 concentrations in 429 apparently healthy elderly individuals and 153 patients with chronic heart failure (CHF). Results: The assay had a detection limit of 20 ng/L, an intraassay imprecision of <10.6%, and an interassay imprecision of <12.2%. Specificity was demonstrated with size-exclusion chromatography, parallel measurements with polyclonal and monoclonal anti-GDF15 antibody, and lack of cross-reactivity with TGF-␤. The assay was not appreciably influenced by the anticoagulant matrix or unrelated biological substances. GDF15 was stable at room temperature for 48 h and resistant to 4 freeze-thaw cycles. Apparently healthy, elderly indi-

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Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage

Cited by 97 publications

References 5 publications

Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma

Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma

GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas

Circulating Concentrations of Growth-Differentiation Factor 15 in Apparently Healthy Elderly Individuals and Patients with Chronic Heart Failure as Assessed by a New Immunoradiometric Sandwich Assay

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