Serum concentrations of major perfluorinated compounds among the general population in Korea: Dietary sources and potential impact on thyroid hormones

Ji, Kyunghee; Kim, Sunmi; Kho, Younglim; Paek, Domyung; Sakong, Joon; Ha, Jongsik; Kim, Sungkyoon; Choi, Kyungho

doi:10.1016/j.envint.2012.03.007

Cited by 132 publications

(100 citation statements)

References 46 publications

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“…PFOS and other PFSAs are widely distributed in the global environment [34][35][36][37][38], biota [39][40][41][42][43][44] and humans [15,[45][46][47][48][49][50][51][52]. Due to the dominance of POSF-based products historically, PFOS is usually the most abundant PFSA found.…”

Section: Perfluoroalkane Sulfonic Acids (Pfsas) and Their Precursorsmentioning

confidence: 99%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

164

122

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Background: There is a concern that continued emissions of man-made per-and polyfluoroalkyl substances (PFASs) may cause environmental and human health effects. Now widespread in human populations and in the environment, several PFASs are also present in remote regions of the world, but the environmental transport and fate of PFASs are not well understood. Phasing out the manufacture of some types of PFASs started in 2000 and further regulatory and voluntary actions have followed. The objective of this review is to understand the effects of these actions on global scale PFAS concentrations.Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations were performed in bibliographic databases, on the internet, through stakeholder contacts and in review bibliographies. No time, document type, language or geographical constraints were applied in the searches. Relevant subjects included human and environmental samples. Two authors screened all retrieved articles. Dual screening of 10% of the articles was performed at title/abstract and full-text levels by all authors. Kappa tests were used to test consistency. Relevant articles were critically appraised by four reviewers, with double checking of 20% of the articles by a second reviewer. Meta-analysis of included temporal trends was considered but judged to not be appropriate. The trends were therefore discussed in a narrative synthesis.

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Section: Perfluoroalkane Sulfonic Acids (Pfsas) and Their Precursorsmentioning

confidence: 99%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

164

122

View full text Add to dashboard Cite

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“…One study observed that only PFTrDA concentrations were positively correlated with TSH levels, but negatively with total T4 concentrations among the female population (Ji et al, 2012). A positive association was detected between PFTrDA in maternal blood serum and T3 and T4 of fetal cord blood serum and between PFOA and cord serum TSH (Kim et al, 2011).…”

Section: Human Studiesmentioning

confidence: 98%

“…More women with blood concentrations of ≥5.7 ng PFOA/mL were found to have currently treated thyroid disease compared with women having ≤ 4.0 ng/mL of blood levels. In a Korean study, investigating the exposure levels of 13 PFCs, they observed no association to PFOA, but only PFTrDA concentrations was positively correlated with TSH level, but negatively with total T4 concentration among the female population (Ji et al, 2012). In summary, possible association for PFOA and thyroid diseases is suggested.…”

Section:  Thyroid Functionmentioning

confidence: 99%

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Per- and polyfluorinated substances in the Nordic Countries

Posner

Roos

Poulsen

et al. 2013

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“…PFOS and other PFSAs are widely distributed in the global environment [52][53][54][55][56], biota [57][58][59][60][61][62] and humans [29,[63][64][65][66][67][68][69][70]. Due to the dominance of POSF-based products historically, PFOS is usually found to be the most abundant PFSA.…”

Section: Perfluoroalkane Sulfonic Acids (Pfsas) and Their Precursorsmentioning

confidence: 99%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review protocol

et al. 2015

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Background: There is a growing concern in Sweden and elsewhere that continued emissions of per-and polyfluoroalkyl substances (PFASs) may cause environmental as well as human health effects. PFASs are a broad class of man-made substances that have been produced and used in both commercial products and industrial processes for more than 60 years. Although the production and use of some PFASs has been phased-out in some parts of the world, it is not known what effect these actions to date have had on PFAS concentrations in the environment. Owing to the wide diversity of PFASs, it is difficult to generalize their properties, environmental fate and production histories. However, the strength and stability of the C-F bond renders the perfluoroalkyl moieties resistant to heat and environmental degradation. Several PFASs are now occurring even in very remote areas in large parts of the world, but the environmental transport and fate of substances within this group is not well understood. A systematic review may be able to determine whether the concentrations of these substances in different environments are changing in any particular direction with time, and whether the phase-outs have had any effects on the concentration trends. Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations in the environment will be performed in the scientific literature as well as in other reports. Relevant samples include both abiotic and biological samples including humans. No particular time, document type, language or geographical constraints will be applied. Two authors will screen all retrieved articles. Double screening of about 10% of the articles will be performed by all authors at both title/abstract and full-text levels. Kappa tests will be used to test if the screening is consistent. Relevant articles will be critically appraised by four authors (double checking of 25% of the articles). Quality assessment will focus on selection bias, dating of samples, sample integrity and analytical procedures. Data synthesis will be based on statistical analysis of temporal concentration trends.

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Serum concentrations of major perfluorinated compounds among the general population in Korea: Dietary sources and potential impact on thyroid hormones

Cited by 132 publications

References 46 publications

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Per- and polyfluorinated substances in the Nordic Countries

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review protocol

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