Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance

Iglesias, Pedro; Arrieta, Francisco; Piñera, Marbella; Botella-Carretero, José I.; Balsa, José Antonio; Zamarrón, Isabel; Menacho, Miriam; Jj, Díez; Munoz, Torres Manuel; Vázquez, Clotilde

doi:10.1111/j.1365-2265.2011.04035.x

Cited by 63 publications

(60 citation statements)

References 21 publications

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“…Increased BMI is associated with reduced bone turnover markers (BTM) and increased aBMD [17,18]. Similar observations with glucose-loading have been made in healthy subjects [15].…”

Section: Introductionsupporting

confidence: 65%

“…Increased cortical porosity of distal radius or distal tibia has been invoked as one possible factor [11][12][13]. However, it is hard to explain how individuals with T2DM can exhibit high porosity [14][15][16][17], since increased cortical porosity reflects increased bone turnover from intracortical surfaces lining the Haversian canals and the endocortical surfaces adjacent to the marrow cavity [18,19]. As T2DM is a condition with low bone turnover [20,21], patients with T2DM would rather be expected to exhibit reduced cortical porosity.…”

Section: Introductionmentioning

confidence: 99%

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Women with type 2 diabetes mellitus have lower cortical porosity of the proximal femoral shaft using low-resolution CT than nondiabetic women, and increasing glucose is associated with reduced cortical porosity

Osima

Kral

Borgen

et al. 2017

Bone

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Increased cortical porosity has been suggested as a possible factor increasing fracture propensity in patients with type 2 diabetes mellitus (T2DM). This is a paradox because cortical porosity is generally associated with high bone turnover, while bone turnover is reduced in patients with T2DM. We therefore wanted to test the hypothesis that women with T2DM have lower bone turnover markers (BTM) and lower cortical porosity than those without diabetes, and that higher serum glucose and body mass index (BMI) are associated with lower BTM, and with lower cortical porosity. Increasing glucose and BMI were associated with lower bone turnover suggesting that reduced intracortical and endocortical remodeling leads to reduced porosity and thicker cortices. Using low-resolution clinical CT, cortical porosity was lower in women with T2DM compared to 3 women without diabetes. This indicates that other changes in bone qualities, not increased cortical porosity, are likely to explain the increased fracture propensity in patients with T2DM.

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“…Increased BMI is associated with reduced bone turnover markers (BTM) and increased aBMD [17,18]. Similar observations with glucose-loading have been made in healthy subjects [15].…”

Section: Introductionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Women with type 2 diabetes mellitus have lower cortical porosity of the proximal femoral shaft using low-resolution CT than nondiabetic women, and increasing glucose is associated with reduced cortical porosity

Osima

Kral

Borgen

et al. 2017

Bone

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show abstract

“…Thus, osteocalcin was inversely associated with plasma glucose, insulin levels, and serum triglycerides in elderly men and women as well as elderly men with high cardiovascular risk (183,184,185,186,187,188). Also, osteocalcin was lower in patients with T2DM (189,190,191) and gestational diabetes (192).…”

Section: Metabolic Aspects In Relation To a Homeostatic Model Involvimentioning

confidence: 90%

Genetics in Endocrinology: Autosomal dominant osteopetrosis revisited: lessons from recent studies

Bollerslev

Henriksen

Nielsen

et al. 2013

European Journal of Endocrinology

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Systematic studies of autosomal dominant osteopetrosis (ADO) were followed by the identification of underlying mutations giving unique possibilities to perform translational studies. What was previously designated ADO1 turned out to be a high bone mass phenotype caused by a missense mutation in the first propeller of LRP5, a region of importance for binding inhibitory proteins. Thereby, ADO1 cannot be regarded as a classical form of osteopetrosis but must now be considered a disease of LRP5 activation. ADO (Albers-Schönberg disease, or previously ADO2) is characterized by increased number of osteoclasts and a defect in the chloride transport system (ClC-7) of importance for acidification of the resorption lacuna (a form of Chloride Channel 7 Deficiency Osteopetrosis). Ex vivo studies of osteoclasts from ADO have shown that cells do form normally but have reduced resorption capacity and an expanded life span. Bone formation seems normal despite decreased osteoclast function. Uncoupling of formation from resorption makes ADO of interest for new strategies for treatment of osteoporosis. Recent studies have integrated bone metabolism in whole-body energy homeostasis. Patients with ADO may have decreased insulin levels indicating importance beyond bone metabolism. There seems to be a paradigm shift in the treatment of osteoporosis. Targeting ClC-7 might introduce a new principle of dual action. Drugs affecting ClC-7 could be antiresorptive, still allowing ongoing bone formation. Inversely, drugs affecting the inhibitory site of LRP5 might stimulate bone formation and inhibit resorption. Thereby, these studies have highlighted several intriguing treatment possibilities, employing novel modes of action, which could provide benefits to the treatment of osteoporosis.

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“…Recent human studies have also shown a relationship between OC and fat and carbohydrate metabolism [11,12]. Osteocalcin has been reported to be decreased in patients with type 2 diabetes [13,14], negatively correlated with fasting plasma glucose, HbA 1c , insulin resistance, C-reactive protein and BMI [15,16], and increased with improved glycaemic control [12,17]. There is increasing evidence that serum osteocalcin level is associated with the presence of metabolic syndrome [18,19].…”

Section: Discussionmentioning

confidence: 99%

Association between serum osteocalcin, adiposity and metabolic risk in obese children and adolescents

Garanty-Bogacka¹,

Syrenicz²,

Rać³

et al. 2013

Endokrynologia Polska

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Introduction: Childhood obesity has been associated with the development of insulin resistance, potentially leading to several metabolic disorders. Osteocalcin has been reported to contribute to the regulation of glucose tolerance and insulin sensitivity. The purpose of this study was to examine the relationship between serum osteocalcin and metabolic risk factors in obese children and adolescents.

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Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance

Cited by 63 publications

References 21 publications

Women with type 2 diabetes mellitus have lower cortical porosity of the proximal femoral shaft using low-resolution CT than nondiabetic women, and increasing glucose is associated with reduced cortical porosity

Women with type 2 diabetes mellitus have lower cortical porosity of the proximal femoral shaft using low-resolution CT than nondiabetic women, and increasing glucose is associated with reduced cortical porosity

Genetics in Endocrinology: Autosomal dominant osteopetrosis revisited: lessons from recent studies

Association between serum osteocalcin, adiposity and metabolic risk in obese children and adolescents

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