Serum concentrations of persistent organic pollutants and colorectal cancer risk: A case-cohort study within Korean National Cancer Center Community (KNCCC) cohort

Park, Eun Young; Kim, Jin-Sun; Oh, Jin-Kyoung; Kim, Byungmi; Lim, Min Kyung

doi:10.1016/j.chemosphere.2021.129596

Cited by 15 publications

(14 citation statements)

References 41 publications

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“…In the initial PubMed searches 165 articles published between 2017 and 2021 were found. After exclusion at various phases as explained above, 63 articles 19,61,64‐124 were included in the final literature sample (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

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Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature. While much of the recent evidence suggests causal relationships between pesticide exposure and cancer, the strongest evidence exists for acute myeloid leukemia (AML) and colorectal cancer (CRC), diseases in which the observed associations were consistent across several studies, including high‐quality prospective studies and those using biomarkers for exposure assessment, with some observing dose‐response relationships. Though high‐quality studies have been published since the IARC monograph on organophosphate insecticides in 2017, there are still gaps in the literature on carcinogenic evidence in humans for a large number of pesticides. To further knowledge, we suggest leveraging new techniques and methods to increase sensitivity and precision of exposure assessment, incorporate multi‐omics data, and investigate more thoroughly exposure to chemical mixtures. There is also a strong need for better and larger population‐based cohort studies that include younger and nonoccupationally exposed individuals, particularly during developmental periods of susceptibility. Though the existing evidence has limitations, as always in science, there is sufficient evidence to implement policies and regulatory action that limit pesticide exposure in humans and, hence, further prevent a significant burden of cancers.

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Section: Resultsmentioning

confidence: 99%

“…Thirty‐three of the 63 studies identified for this review assessed exposure to pesticides prospectively, prior to cancer development 19,61,64‐93 . These studies provide the strongest evidence due not only to their prospective and precise exposure assessment, but also due to large sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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“…In a population-based case-control study in the United States in 2005, higher chlorinated PCBs were associated with an increased risk of non-Hodgkin’s lymphoma [ 100 ]. Additionally, exposure to PCBs is also associated with the development of colorectal cancer [ 101 ], which was the second most common cause of cancer death worldwide in 2020 [ 102 ]. Overall, the risk of cancer is 20% higher in men with exposure to PCB [ 103 ].…”

Section: Health Impactmentioning

confidence: 99%

A Review of Polychlorinated Biphenyls (PCBs) Pollution in the Air: Where and How Much Are We Exposed to?

Othman

Ismail

Selamat

et al. 2022

IJERPH

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Polychlorinated biphenyls (PCBs) were widely used in industrial and commercial applications, until they were banned in the late 1970s as a result of their significant environmental pollution. PCBs in the environment gained scientific interest because of their persistence and the potential threats they pose to humans. Traditionally, human exposure to PCBs was linked to dietary ingestion. Inhalational exposure to these contaminants is often overlooked. This review discusses the occurrence and distribution of PCBs in environmental matrices and their associated health impacts. Severe PCB contamination levels have been reported in e-waste recycling areas. The occurrence of high PCB levels, notably in urban and industrial areas, might result from extensive PCB use and intensive human activity. Furthermore, PCB contamination in the indoor environment is ten-fold higher than outdoors, which may present expose risk for humans through the inhalation of contaminated air or through the ingestion of dust. In such settings, the inhalation route may contribute significantly to PCB exposure. The data on human health effects due to PCB inhalation are scarce. More epidemiological studies should be performed to investigate the inhalation dose and response mechanism and to evaluate the health risks. Further studies should also evaluate the health impact of prolonged low-concentration PCB exposure.

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“…These key datasets include: 1) population-scale biomonitoring surveys; 2) targeted analysis of multiple analytes in hypothesis-driven studies (typically 10–100); and 3) untargeted analysis of thousands of chemicals using a high-resolution mass spectrometry instrument ( Barupal et al, 2021a ; David et al, 2021 ). They cover key high priority exposome chemicals ( Barupal et al, 2021b ) including carcinogens ( Hecht et al, 2016 ; Park et al, 2021 ), endocrine disrupters ( Kassotis et al, 2020 ) and industry chemicals ( Shearer et al, 2021 ). These core datasets support different statistical and bioinformatics analyses to reveal novel risk factors, hidden metabolic pathways, detrimental exposures and biomarkers for disease.…”

Section: Introductionmentioning

confidence: 99%

CCDB: A database for exploring inter-chemical correlations in metabolomics and exposomics datasets

Barupal

Mahajan

Baygi

et al. 2022

Environment International

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Serum concentrations of persistent organic pollutants and colorectal cancer risk: A case-cohort study within Korean National Cancer Center Community (KNCCC) cohort

Cited by 15 publications

References 41 publications

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

A Review of Polychlorinated Biphenyls (PCBs) Pollution in the Air: Where and How Much Are We Exposed to?

CCDB: A database for exploring inter-chemical correlations in metabolomics and exposomics datasets

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