Serum concentrations of small dense low‐density lipoprotein cholesterol and lipoprotein(a) are related to coronary arteriostenosis in Takayasu arteritis

Chen, Si; Luan, Haixia; He, Jianxun; Yan, Wei; Liu, Shuang; Li, Yongzhe; Zeng, Xiaoli; Yuan, Hui

doi:10.1002/jcla.23966

Cited by 6 publications

(4 citation statements)

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“…Our study is the first to investigate the level of sdLDL in a North African population and our results also show that there was a significant increase in the sdLDL levels of ACS patients. However, while the sdLDL levels of the ACS patients were approximately 13 times that of the healthy control subjects (0.303 ± 0.478 mmol/L vs. 0.0225 ± 0.043, respectively), they remained 2-to-3 times lower than those determined in previous studies [ 21 , 22 , 23 , 24 , 25 , 26 ]. This discrepancy between different studies with respect to the level of sdLDL that could be associated with a higher cardiovascular risk can be attributed to factors that include ethnicity, the methodology used to quantify plasma sdLDL levels and even the definition of the sdLDL fraction itself [ 27 , 28 ].…”

Section: Discussioncontrasting

confidence: 62%

“…Duran et al have shown that the risk of occurrence of cardiac events increases significantly with an sdLDL level of 1.28 mmol/L [ 6 ], and Higashioka et al have shown that the risk increases significantly with an sdLDL level as low as 0.90 mmol/L [ 21 ]. Other studies have reported an increase in the incidence of cardiovascular events for lower sdLDL levels (for instance, 0.60 mmol/L) [ 21 , 22 , 23 , 24 , 25 , 26 ]. Our study is the first to investigate the level of sdLDL in a North African population and our results also show that there was a significant increase in the sdLDL levels of ACS patients.…”

Section: Discussionmentioning

confidence: 99%

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Small Dense LDL Level and LDL/HDL Distribution in Acute Coronary Syndrome Patients

et al. 2023

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This study aimed to determine the size and distribution of LDL and HDL particles in North African acute coronary syndrome (ACS) patients and to compare the level of small dense LDL (sdLDL) to other markers used in cardiovascular risk prediction. Methods: A total of 205 ACS patients and 100 healthy control subjects were enrolled. LDL particle size and LDL and HDL subclass distributions were measured using Quantimetric Lipoprint® linear polyacrylamide gel electrophoresis. Lipid ratios (total cholesterol, LDL cholesterol, non-HDL cholesterol, and HDL cholesterol) were determined to calculate the atherogenic index of plasma (AIP), the atherogenic coefficient (AC), Castelli’s Risk-I (CR-I), and Castelli’s Risk-II (CR-II). Receiver operating characteristic (ROC) curve analyses and area under the curve (AUC) were used to assess the predictive value of sdLDL as a marker for cardiovascular disease. Results: The ACS patients, compared to the healthy control subjects, displayed an alteration of LDL particle distribution, with a significant increase in sdLDL serum concentrations (0.303 ± 0.478 mmol/L vs. 0.0225 ± 0.043 mmol/L, respectively, p < 0.001). The sdLDL levels had a high discrimination accuracy [AUC = 0.847 ± 0.0353 (95% CI 0.778 to 0.916, p < 0.0001)]. The best predictive cutoff value of ACS determined with the maximum Youden index (J) [(sensitivity + specificity) − 1 = 0.60] was 0.038 mmol/L. A Spearman correlation analysis showed that sdLDL levels were moderately but significantly and positively correlated with AC and CR-I (r = 0.37, p < 0.001) and weakly but significantly correlated with PAI and CR-II; r = 0.32 (p < 0.001) and r = 0.30 (p < 0.008), respectively. The subclass distribution of HDL particles from ACS patients was also altered, with a decrease in large HDL particles and an increase in small HDL particles compared to HDL from healthy control subjects. Conclusion: Due to their high atherogenicity, sdLDL levels could be used as a valuable marker for the prediction cardiovascular events.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Small Dense LDL Level and LDL/HDL Distribution in Acute Coronary Syndrome Patients

et al. 2023

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“… 43 Chen et al found that serum Lp(a) levels increased the risk of coronary stenosis and the best predictive threshold for coronary stenosis was 0.185g/L. 44 However, what level of Lp(a) will significantly increase the risk of CAD in patients with T2DM has not yet been studied. We explored the Lp(a) levels associated with the occurrence of CAD in different population and found that the threshold value of Lp(a) for the occurrence of CAD was lower in patients with T2DM than in patients without T2DM.…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein(a) as a Higher Residual Risk for Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus than without

Yu,

Hu,

Liu

et al. 2023

IJGM

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Purpose: Lipoprotein(a) (Lp[a]) is well-known as a residual risk factor for coronary artery disease (CAD). However, the different adverse effects of Lp(a) about CAD in patients with or without type 2 diabetes mellitus (T2DM) are unclear. This study aimed to investigate the Lp(a) thresholds for CAD diagnosis in T2DM and non-T2DM patients, and further compare the Lp(a) alarm values along with optimal low-density lipoprotein cholesterol (LDL-C) level. Methods: This retrospective study consecutively enrolled patients with suspected CAD who underwent coronary angiography in Guangdong Provincial People's Hospital between September 2014 and July 2015. A logistic regression model was established to explore the association of Lp(a) and CAD in patients. Restricted cubic splines were used to compare the threshold values of Lp(a) for CAD in patients with and without T2DM, and further in optimal LDL-C level situation. Results: There were 1522 patients enrolled finally. After multivariable adjustment, Lp(a) was an independent risk factor for CAD in patients with T2DM (odds ratio [OR]: 1.98, 95% CI]: 1.12-3.49, p = 0.019) and without T2DM (OR: 3.42, 95% CI: 2.36-4.95, p < 0.001). In the whole population, the Lp(a) threshold of CAD was 155, while 145 mg/L for T2DM and 162 mg/L for non-T2DM ones, respectively. In patients with LDL-C<1.8 mmol/l, the alarm value of Lp(a) was even lower in T2DM than non-T2DM patients (155 vs 174 mg/L). Conclusion: Lp(a) was a significant residual risk for CAD in patients whether with T2DM or not. And Lp(a) had a lower alarm value in T2DM patients, especially in optimal LDL-C level.

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“…В исследовании Chen с соавт. (2021) отмечено, что пациенты с НАА демонстрируют более атерогенный липидный профиль по сравнению со здоровым контролем, что коррелировало со степенью поражения коронарного русла [29]. Наруше-ния липидного обмена не только являются самостоятельным фактором развития ССЗ, но и, согласно L. Pan с соавт.…”

Section: результаты и обсуждениеunclassified

Characteristics of patients with non-specific aortoarteritis and arterial hypertension based on retrospective analysis

Shamshilina,

Blinova,

Chikhladze

et al. 2023

jour

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The aim was to study the medical history, laboratory and instrumental data, the trends of arterial hypertension (AH), risk factors for cardiovascular events, target organ damage (TOD), and the development of cardiovascular complications in patients with NSAA (Non-Specific Aortoarteritis).Materials and Methods. The study included 33 women with confirmed NSAA who had been treated at the 5th Cardiology Department of the E.I. Chazov National Medical Research Center of Cardiology since 2005. Complete blood count, biochemical blood analysis, urine analysis, the following instrumental examinations, such as, ECG, echocardiography, ultrasound of the brachial, femoral, aortic, and renal arteries, MRA or CT angiography with contrast, blood pressure measurement in the arms and legs were performed for all patients. Telephone interviews were conducted to assess some patient's condition over time.Results. The most common symptom (84% of patients) was AH, the average age of AH onset was 30 [19; 40] years and the AH average duration is 7,5 [2; 13] years. Nearly half of the patients (45%) had AH as the leading symptom that led them to perform the examination that helped to the diagnosis of NSAA. The average systolic and diastolic blood pressure values were 123±35 mmHg and 66±17 mmHg in the upper extremities, and 166±31 mmHg and 78±18 mmHg in the lower extremities, respectively. About half of patients (51%) had stage 3 AH, and almost all of them had type 3 according to E. Lupi-Herrera classification. The most common risk factors for cardiovascular events were dyslipidemia (82%), a family history of early cardiovascular events (51%), resting heart rate above 80 bpm (25%), and carbohydrate metabolism disorders (21%). When assessing cardiovascular risk, moderate risk of developing cardiovascular events was observed in 3 patients (10,7%), high risk in 16 patients (57,1%), and very high risk in 9 patients (32,1%). The most common TODs were nervous system damage (53%), including cerebrovascular ischemic events (14%) and left ventricular hypertrophy (42%). This group of patients was characterized by resistant hypertension, and combination with other risk factors for cardiovascular events, it leds to severe TOD and influenced survival rate. In terms of antihypertensive therapy, 61% of patients received combination therapy, with CCB, beta-blockers, and imidazoline receptor agonist being the most prescribed. Two fatal cases were identified in the long-term follow-up, and cardiovascular events, most frequently stroke, were the main complications observed. Additionally, AH progression and its uncontrolled course despite going through multiple drug therapy were characteristic.Conclusion: AH is often difficult to diagnostic in patients with NSAA, and it significantly contributes to the structure of complications and mortality in this patient cohort, progressively worsening over time. It is important to measure blood pressure in both arms and legs to detect elevated values early. The main goals of treatment are achieving NSAA remission and blood pressure control and preventing cardiovascular events.

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Serum concentrations of small dense low‐density lipoprotein cholesterol and lipoprotein(a) are related to coronary arteriostenosis in Takayasu arteritis

Cited by 6 publications

References 64 publications

Small Dense LDL Level and LDL/HDL Distribution in Acute Coronary Syndrome Patients

Small Dense LDL Level and LDL/HDL Distribution in Acute Coronary Syndrome Patients

Lipoprotein(a) as a Higher Residual Risk for Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus than without

Characteristics of patients with non-specific aortoarteritis and arterial hypertension based on retrospective analysis

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