Serum concentrations of soluble transferrin receptor among paediatric patients with transfusion-dependant β-thalassaemia/haemoglobin E

Study of Beta-Thalassemia Biomarkers and Their Relationship to Cognition Among Children

“…[18][19][20][21] A number of studies previously demonstrated that the serum transferrin receptors concentration was a good indicator for evaluating the erythropoietic activity in different genotypes of thalassemia. [20][21][22][23][24] Its value was markedly increased in thalassemia diseases, but slightly increased in thalassemia heterozygotes. 17 Beta-thalassemia is a disorder characterized by the defective production of hemoglobin and the excessive destruction of red blood cells.…”

Molecular Structure of Human Transferrin – Transferrin Receptor Complex

“…Tf was discovered more than half a century ago, however, the discovery of TfR was just in the past two decades. Considering human iron metabolism, most cells acquire iron from plasma Tf and it is the TfR that is responsible for the internalization of transferrin-bound iron and its subsequent intracellular release [4]. Not only the carrying of iron, TfRs have also shown potentials in delivery of therapeutic drugs or genes into the brain across blood-brain barrier [7].…”

“…Presently, the determination of sTfR becomes a widely used tool for measuring erythropoiesis [1][2][3], but most tests are mainly restricted to research laboratory settings. At present, plasma concentrations of the receptor reflect cellular receptor numbers and may be determined by enzyme immunoassay on automated analyzer [4]. Recently, Bhokaisawan et al studied the diagnostic value of sTfR and they found that sTfR could be used as an alternative test for monitoring of erythropoiesis [5].…”