Serum concentrations of β-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population

Galán, Pilar; Fe, Viteri; Bertrais, Sandrine; Czernichow, Sébastien; Faure, Henri; Arnaud, Josiane; Ruffieux, D.; S, Chenal; Arnault, Nathalie; Favier, Alain; Am, Roussel; Herçberg, Serge

doi:10.1038/sj.ejcn.1602230

Cited by 264 publications

(267 citation statements)

References 61 publications

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“…We found an inverse association between energy intake and serum retinol and -tocopherol concentrations. This is in agreement with some previous studies [45][46][47], but others have shown positive or no relation of energy intake to blood -tocopherol or retinol levels [14,47,48].…”

Section: Discussionsupporting

confidence: 82%

“…It is similar with results of others, who also observed that low intakes of alcohol have not been related to a decrease of antioxidant vitamins in the human body [14,45,47,54]. It is known that alcohol may increase oxidation of -tocopherol and retinol and reduce body stores [12,54,60], but the oxidative stress by alcohol depends on the amount and frequency of alcoholic beverage consumed [61,62].…”

Section: Discussionsupporting

confidence: 79%

“…There was no significance difference between mean serum retinol and -tocopherol concentration among ov/ob and normal weight female participants in the study reported here. Our results are consistent with those previously described in Italy [49], Greece [47], France [35,45], Spain [35,67] and in USA adult female populations from urbanized areas [17,35]. In contrast to our findings, Viroonudomphol et al [18], Ohrvall et al [68] reported lower serum levels of -tocopherol concentration in Thai and Swedish adult women populations.…”

Section: Discussioncontrasting

confidence: 57%

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HPLC Assessment and Multivariate Predictability of Serum Retinol and α-Tocopherol Concentrations in Adult Female Subjects

Jaworowska¹,

Bazylak²

2008

TOCBMJ

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Antioxidant vitamins have been reported to protect against a variety of human malignances and multiple chronic degenerative diseases therefore it is important to understand factors that influence their blood levels. The present study was conducted to verify association of serum retinol and -tocopherol levels with obesity, and to assess predictors of their serum concentrations in representative sample population of overweight/obese (n = 51) and normal weight (n = 26) apparently healthy adult female subjects recruited from typical urban area in Poland. Anthropometric measurements were taken from all participants who also completed a questionnaire on selected lifestyle factors. The serum concentrations of retinol and -tocopherol were measured by fully validated Chromsystems diagnostic kit employing isocratic RP-HPLC with switched wavelength UV detection. Intake of energy, fat, vitamin A and E and alcohol consumption were estimated by seven daily dietary records. Multivariate linear regression models were fitted in order to estimate the predictors of serum retinol and -tocopherol concentration. There were no statistically significant differences in the average serum levels of retinol and -tocopherol between overweight/obese and normal weight adult female subjects. Serumtocopherol concentrations were positively correlated with serum total cholesterol level (TChol) and body mass index (BMI), but inversely with total energy intake and past dieting behaviour. The TChol and total energy intake were identified as predictors of serum retinol levels. Intakes of fat and vitamin E and A, age, serum triglyceride concentration, smoking, alcohol consumption and physical activity were unrelated to serum levels of retinol or -tocopherol. The main finding of this study is that obesity is not associated with decreased serum retinol and -tocopherol levels. In addition, these results indicated that dietary intake of vitamin A and E are poor predictors for serum retinol or -tocopherol concentrations. Serum levels of both these vitamins are primarily influenced by TChol, obesity, total energy intake and past dieting behaviour.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 79%

Section: Discussioncontrasting

confidence: 57%

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HPLC Assessment and Multivariate Predictability of Serum Retinol and α-Tocopherol Concentrations in Adult Female Subjects

Jaworowska¹,

Bazylak²

2008

TOCBMJ

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“…Galan et al reported significantly lower plasma levels of vitamin A and C and insignificantly lower plasma levels of vitamin E in the French adult population in a group of obese subjects compared to healthy individuals [31].…”

Section: Discussionmentioning

confidence: 99%

Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic Syndrome: A Case Control Study

Godala¹,

Materek-Kuśmierkiewicz²,

Moczulski³

et al. 2016

Adv Clin Exp Med

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blood pressure or hypertension treatment, fasting hyperglycemia or diagnosed type 2 diabetes, abnormal lipid profile (hypertriglyceridemia and/or low HDL-cholesterol) A -research concept and design; B -collection and/or assembly of data; C -data analysis and interpretation; D -writing the article; E -critical revision of the article; F -final approval of article AbstractBackground. Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting the development of cardiovascular diseases. Reactive oxygen species, which are excessively produced in MS, participate in its pathogenesis. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans. Objectives. The aim of the study was to estimate plasma vitamin A, C and E levels and the intake of these vitamins from the diet in patients with MS. Material and Methods. The study included 182 patients with MS, 94 men and 88 women, aged 30-65 years (mean 57.31 ± 8.28 years). The control group was comprised of 91 subjects, 56 men and 35 women, aged 41-65 years (mean 57.75 ± 5.84 years). The MS diagnosis was based on IDF criteria. The determination of the serum level of vitamin A, C and E was performed using the spectrophotometric method. The food intake was assessed by 24-h dietary recall. Results. The mean plasma vitamin A, C and E levels were significantly lower in MS patients than in the controls (p = 0.05). No correlation was found between vitamin A, C and E intake from the diet and their plasma concentrations in MS patients. Plasma vitamin A, C and E deficiency was observed significantly more often in MS patients than in the control group (15.38% vs. 2.19%, 79.12% vs. 8.79% and 60.45% vs. 5.49%, p < 0.0001, respectively). BMI was the one factor significantly affecting the mean value of vitamin A, C and E levels in MS patients. Conclusions. MS patients demonstrated significantly lower plasma levels of vitamin A, C and E compared to the healthy subjects. Lower plasma levels of antioxidant vitamins with their high intake from the diet indicate antioxidant barrier impairment in MS patients (Adv Clin Exp Med 2016, 25, 4, 689-700).

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“…12 Nevertheless, levels of these biomarkers have also been suggested to be correlated to gender, age and smoking status, with lower levels of vitamin C and carotenoids in smokers and higher levels in women, especially younger women. [13][14][15] In the studies included in the WCRF report, dietary intake was assessed by dietary questionnaires and concentrations of vitamins in foods were calculated using food composition tables. These methods are, however, prone to measurement error and may not fully take into account the bioavailability of dietary nutrients.…”

mentioning

confidence: 99%

Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case–control study

Jeurnink

Ros

Leenders

et al. 2014

Intl Journal of Cancer

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Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (α‐ and β‐carotene, lycopene, β‐cryptoxanthin, canthaxanthin, zeaxanthin and lutein), α‐ and γ‐tocopherol and retinol were measured by reverse phase high‐performance liquid chromatography and plasma vitamin C by a colorimetric assay. Incidence rate ratios (IRRs) with 95% confidence intervals (95%CIs) for pancreatic cancer risk were estimated using a conditional logistic regression analysis, adjusted for smoking status, smoking duration and intensity, waist circumference, cotinine levels and diabetes status. Inverse associations with pancreatic cancer risk were found for plasma β‐carotene (IRR highest vs. lowest quartile 0.52, 95%CI 0.31–0.88, p for trend = 0.02), zeaxanthin (IRR highest vs. lowest quartile 0.53, 95%CI 0.30–0.94, p for trend = 0.06) and α‐tocopherol (IRR highest vs. lowest quartile 0.62, 95%CI 0.39–0.99, p for trend = 0.08. For α‐ and β‐carotene, lutein, sum of carotenoids and γ‐tocopherol, heterogeneity between geographical regions was observed. In conclusion, our results show that higher plasma concentrations of β‐carotene, zeaxanthin and α‐tocopherol may be inversely associated with risk of pancreatic cancer, but further studies are warranted.

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Serum concentrations of β-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population

Cited by 264 publications

References 61 publications

HPLC Assessment and Multivariate Predictability of Serum Retinol and α-Tocopherol Concentrations in Adult Female Subjects

HPLC Assessment and Multivariate Predictability of Serum Retinol and α-Tocopherol Concentrations in Adult Female Subjects

Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic Syndrome: A Case Control Study

Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case–control study

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