Serum Conjugated Linoleic Acid and Risk of Incident Heart Failure in Older Men: The British Regional Heart Study

Wannamethee, SG; Jefferis, Barbara J.; Lennon, Lucy; Papacosta, Olia; Whincup, Peter H.; Hingorani, Aroon D.

doi:10.1161/jaha.117.006653

Cited by 20 publications

(9 citation statements)

References 34 publications

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“…Furthermore, lower levels of apoB and apoB/apoA1 -ratio were detected that have also associated with attenuated risk of cardiovascular/heart outcomes (22,23). These anti-atherogenic effects were further promoted by increased levels of conjugated linoleic acids that has been previously associated with lower risk of heart failure (24).…”

Section: Changes In Body Composition Reflect Alteration In Metabolomementioning

confidence: 84%

Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways

Sarin

Ahtiainen

Hulmi

et al. 2019

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction: Arising evidence suggests that resistance training has the potential to induce beneficial modulation of biomarker profile. To date, however, only immediate responses to resistance training have been investigated using high-throughput metabolomics whereas the effects of chronic resistance training on biomarker profile have not been studied in detail. Methods: A total of 86 recreationally active healthy men without previous systematic resistance training background were allocated into i) a resistance training (RT) group (n=68, age 33 ± 7 years, body mass index (BMI) 28 ± 3 kg/m 2) and ii) a non-RT group (n=18, age 31 ± 4 years, BMI 27 ± 3 kg/m 2). Blood samples were collected at baseline (PRE), after 4 weeks (POST-4wk), and after 16 weeks of resistance training intervention (POST-16wk), as well as baseline and after the non-RT period (20-24 weeks). Nuclear magnetic resonance (NMR)-metabolome platform was used to determine metabolomic responses to chronic resistance training. Results: Overall, the resistance training intervention resulted in favorable alterations (P < 0.05) in body composition with increased levels of lean mass (~2.8 %), decreased levels of android (~9.6 %), and total fat mass (~7.5 %). These changes in body composition were accompanied by anti-atherogenic alterations in serum metabolome profile (FDR < 0.05) as reductions in non-HDL cholesterol (e.g., free cholesterol, remnant cholesterol, IDL cholesterols, LDL cholesterols) and related apolipoprotein B, and increments in conjugated linoleic fatty acids levels were observed. Individuals with the poorest baseline status (i.e. body composition, metabolome profile) benefitted the most from the resistance training intervention.

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Section: Changes In Body Composition Reflect Alteration In Metabolomementioning

confidence: 84%

Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways

Sarin

Ahtiainen

Hulmi

et al. 2019

Medicine &Amp; Science in Sports &Amp; Exercise

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“…The results of the single CLA isomer in humans has shown that rumenic acid has a relatively beneficial influence, whereas t 10, c 12CLA seems to exert a proatherogenic effect as it decreases high density lipoproteins (HDL) and increases triacylgycerols (TAG) and very low density lipoproteins (VLDL) levels in obese male subjects [59]. An elevated CLA percentage share in the total FA pool in the serum of elderly men was adversely associated with cholesterol, high-density lipoprotein cholesterol, and reduced heart failure risk—but only for those with higher dairy fat intake as a major dietary source of CLA isomers (test for interaction, p = 0.03) [60]. Interestingly, CLA isomers given to female SPRD rats did not influence the cardiac function in contract to male SPRD rats, in which CLA isomers decreased heart rate, diastolic pressure, and systolic pressure [39].…”

Section: Discussionmentioning

confidence: 99%

Conjugated Linoleic Acid Isomers Affect Profile of Lipid Compounds and Intensity of Their Oxidation in Heart of Rats with Chemically-Induced Mammary Tumors—Preliminary Study

Białek

Czauderna

2019

Nutrients

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Breast cancer and cardiovascular diseases (CVD) have shared risk factors and mechanisms of pathogenicity, as proven by increased cardiac risk in breast cancer patients receiving anticancerogenic therapies and in cancer survivors. A growing mammary tumor may cause heart injury in cancer patients who have not yet been treated. This study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplementation of female rats with 7,12-dimethylbenz(a)anthracene (DMBA)-induced cancerogenesis on fatty acids (FAs), conjugated FAs (CFAs), malondialdehyde (MDA), cholesterol and oxysterols content in cardiac tissue. FAs, cholesterol and oxysterols contents were determined by gas chromatography coupled with mass spectrometry, while the contents of CFAs and MDA were determined by high performance liquid chromatography with photodiode detection. Our results indicate that both CLA supplementation and the presence of tumors influence the lipid biomarkers of CVD. A significant interaction of both experimental factors was observed in the content of polyunsaturated FAs (PUFAs), n-6 PUFAs and CFAs. CLA supplementation significantly inhibited PUFA oxidation, as evidenced by the lower content of MDA in rats’ hearts, while the cancerous process intensified the oxidation of cholesterol, as confirmed by the elevated levels of 7-ketocholesterol in DMBA-treated rats. These results may significantly expand knowledge about CLA properties in terms of the prevention of co-existing non-communicable diseases.

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“…Further studies indicate that c9, t11-CLA exhibit potent anti-inflammatory effects against IL-6 and TNF-α expression, as well as adiponectin secretion in 3T3-L1 adipocytes [ 190 , 191 ]. A recent study has also shown that high dairy fat intake was not associated with incident coronary heart disease but was associated with reduced risk of HF, largely because of the inverse effect of the presence of serum CLA (measured as a % of total fatty acids), which is elaborated further in Table 1 [ 172 ]. Furthermore, as reviewed by Lordan and Zabetakis [ 4 ], CLA enriched dairy products has a neutral or positive effect on circulating inflammatory markers and lipid profiles of healthy and diseased participants.…”

Section: Trans Fatty Acidsmentioning

confidence: 99%

Dairy Fats and Cardiovascular Disease: Do We Really Need to Be Concerned?

Lordan

Τσούπρας

Mitra³

2018

Foods

219

137

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Cardiovascular diseases (CVD) remain a major cause of death and morbidity globally and diet plays a crucial role in the disease prevention and pathology. The negative perception of dairy fats stems from the effort to reduce dietary saturated fatty acid (SFA) intake due to their association with increased cholesterol levels upon consumption and the increased risk of CVD development. Institutions that set dietary guidelines have approached dairy products with negative bias and used poor scientific data in the past. As a result, the consumption of dairy products was considered detrimental to our cardiovascular health. In western societies, dietary trends indicate that generally there is a reduction of full-fat dairy product consumption and increased low-fat dairy consumption. However, recent research and meta-analyses have demonstrated the benefits of full-fat dairy consumption, based on higher bioavailability of high-value nutrients and anti-inflammatory properties. In this review, the relationship between dairy consumption, cardiometabolic risk factors and the incidence of cardiovascular diseases are discussed. Functional dairy foods and the health implications of dairy alternatives are also considered. In general, evidence suggests that milk has a neutral effect on cardiovascular outcomes but fermented dairy products, such as yoghurt, kefir and cheese may have a positive or neutral effect. Particular focus is placed on the effects of the lipid content on cardiovascular health.

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Serum Conjugated Linoleic Acid and Risk of Incident Heart Failure in Older Men: The British Regional Heart Study

Cited by 20 publications

References 34 publications

Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways

Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways

Conjugated Linoleic Acid Isomers Affect Profile of Lipid Compounds and Intensity of Their Oxidation in Heart of Rats with Chemically-Induced Mammary Tumors—Preliminary Study

Dairy Fats and Cardiovascular Disease: Do We Really Need to Be Concerned?

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