Serum conversion pattern of SCC-Ag levels between pre- and post-chemoradiotherapy predicts recurrence and metastasis in cervical cancer: a multi-institutional analysis

Lee, Sea-Won; Hong, Ji Hyung; Yu, Mina; Jeong, Sungmoon; Kim, Sung Hwan; Kim, Yeon‐Sil; Lee, Sung Jong; Lee, Jong Hoon

doi:10.1007/s10585-021-10115-w

Cited by 8 publications

(10 citation statements)

References 30 publications

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“…Multivariate analysis further confirmed that SCCAg was an independent predictor of cervical squamous cell carcinoma and adenocarcinoma ( P = 0.009, OR = 0.671, 95% CI = 0.497–0.905). SCCAg is a subcomponent of TA-4 extracted from cervical squamous cell carcinoma, and its serum level can be used as one of the auxiliary indicators for the diagnosis, efficacy evaluation and prognosis prediction of cervical squamous cell carcinoma [ 23 – 25 , 33 – 35 ]. Therefore, we believe that serum SCCAg levels can play a good role in the differentiation of cervical squamous cell carcinoma and adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

The value of HPV genotypes combined with clinical indicators in the classification of cervical squamous cell carcinoma and adenocarcinoma

Chen

et al. 2022

BMC Cancer

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Background To investigate the differences in HPV genotypes and clinical indicators between cervical squamous cell carcinoma and adenocarcinoma and to identify independent predictors for differentiating cervical squamous cell carcinoma and adenocarcinoma. Methods A total of 319 patients with cervical cancer, including 238 patients with squamous cell carcinoma and 81 patients with adenocarcinoma, were retrospectively analysed. The clinical characteristics and laboratory indicators, including HPV genotypes, SCCAg, CA125, CA19-9, CYFRA 21–1 and parity, were analysed by univariate and multivariate analyses, and a classification model for cervical squamous cell carcinoma and adenocarcinoma was established. The model was validated in 96 patients with cervical cancer. Results There were significant differences in SCCAg, CA125, CA19-9, CYFRA 21–1, HPV genotypes and clinical symptoms between cervical squamous cell carcinoma and adenocarcinoma (P < 0.05). Logistic regression analysis showed that SCCAg and HPV genotypes (high risk) were independent predictors for differentiating cervical squamous cell carcinoma from adenocarcinoma. The AUC value of the established classification model was 0.854 (95% CI: 0.804–0.904). The accuracy, sensitivity and specificity of the model were 0.846, 0.691 and 0.899, respectively. The classification accuracy was 0.823 when the model was verified. Conclusion The histological type of cervical cancer patients with persistent infection of high-risk HPV subtypes and low serum SCCAg levels was more prone to being adenocarcinoma. When the above independent predictors occur, the occurrence and development of cervical adenocarcinoma should be anticipated, and early active intervention treatment should be used to improve the prognosis and survival of patients.

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Section: Discussionmentioning

confidence: 99%

The value of HPV genotypes combined with clinical indicators in the classification of cervical squamous cell carcinoma and adenocarcinoma

Chen

et al. 2022

BMC Cancer

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“…Serum tumor markers play an important role in the monitoring of cervical cancer and are independent prognostic factors. Many studies have confirmed that squamous cell carcinoma antigen (SCC-Ag), cancer antigen 125 (CA125), carcino-embryonic antigen (CEA) play an important role to evaluate prognosis, therapeutic response, local recurrence and distant metastasis in cervical squamous cell carcinoma and adenocacinoma ( Dasari et al, 2015 , Lee et al, 2021 , Zhou et al, 2017 , Huang et al, 2020 , Meng et al, 2021 , Volkova et al, 2021 , Bender et al, 2003 Jul , Kubota et al, 2019 ). For relatively concealed lesions, when no lesions that can explain the symptoms are found in the routine imaging examination and the serum tumor markers increase at the same time, MRI examinationis should be recommended to determine whether there is SEM.…”

Section: Discussionmentioning

confidence: 99%

Spinal epidural metastasis from cervical cancer: Report of two cases and literature review

Sun

Gong²,

Zhang³

2022

Gynecologic Oncology Reports

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“…SCC Ag is considered to be the most clinically valuable serum tumor marker of SCC, and its levels are usually associated with larger primary tumors, later stage, and lymph node involvement ( 8 – 10 ). Of note, nearly a quarter of CC patients do not have elevated SCC Ag levels ( 11 ). Furthermore, almost all CCs are related to high-risk human papillomavirus (HPV) infections, of which nearly 50% are HPV16 infections ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

Fatty acid metabolism: A new therapeutic target for cervical cancer

Ping

Lei

et al. 2023

Front. Oncol.

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Cervical cancer (CC) is one of the most common malignancies in women. Cancer cells can use metabolic reprogramming to produce macromolecules and ATP needed to sustain cell growth, division and survival. Recent evidence suggests that fatty acid metabolism and its related lipid metabolic pathways are closely related to the malignant progression of CC. In particular, it involves the synthesis, uptake, activation, oxidation, and transport of fatty acids. Similarly, more and more attention has been paid to the effects of intracellular lipolysis, transcriptional regulatory factors, other lipid metabolic pathways and diet on CC. This study reviews the latest evidence of the link between fatty acid metabolism and CC; it not only reveals its core mechanism but also discusses promising targeted drugs for fatty acid metabolism. This study on the complex relationship between carcinogenic signals and fatty acid metabolism suggests that fatty acid metabolism will become a new therapeutic target in CC.

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Serum conversion pattern of SCC-Ag levels between pre- and post-chemoradiotherapy predicts recurrence and metastasis in cervical cancer: a multi-institutional analysis

Cited by 8 publications

References 30 publications

The value of HPV genotypes combined with clinical indicators in the classification of cervical squamous cell carcinoma and adenocarcinoma

The value of HPV genotypes combined with clinical indicators in the classification of cervical squamous cell carcinoma and adenocarcinoma

Spinal epidural metastasis from cervical cancer: Report of two cases and literature review

Fatty acid metabolism: A new therapeutic target for cervical cancer

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