Serum Copper and Zinc Concentrations and Cognitive Impairment in Older Adults Aged 60 Years and Older

Gong, Zonglin; Song, Wenlei; Gu, Minjun

doi:10.1007/s12011-021-02765-4

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…Dietary intakes of zinc, copper, selenium and magnesium were found inversely associated with cognitive impairment [ 13 , 26 ]. In addition, blood selenium, copper and zinc were also inversely associated with cognitive impairment [ 27 , 28 ]. However, blood cadmium was associated with worse cognitive function [ 29 ] while no association was found between blood lead and cognitive performance [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Association between serum iron concentrations and cognitive impairment in older adults aged 60 years and older: A dose-response analysis of National Health and Nutrition Examination Survey

Gong¹,

Song²,

Gu³

et al. 2021

PLoS ONE

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Epidemiological evidence on peripheral iron and cognitive impairment in older adults is sparse and limited. Results on serum iron and cognitive impairment in older adults from the National Health and Nutrition Examination Survey have not been reported. Data on serum iron and cognitive impairment from individuals ≥ 60 years of age were obtained from the 2011–2014 NHANES (N = 3,131). Serum iron concentrations were determined with DcX800 method. Cognitive impairment was assessed with four cognitive tests: the Digit Symbol Substitution Test (DSST), the Animal Fluency (AF), the Consortium to Establish a Registry for Alzheimer’s Disease Delayed Recall (CERAD-DR) and Word Learning (CERAD-WL) tests. Logistic regression and restricted cubic splines were adopted to explore the dose-response relationship between serum iron concentrations and cognitive impairment. Comparing the highest to lowest tertile of serum iron concentrations, the multivariate-adjusted odds ratios of scoring low on the DSST were 0.70 (0.49–1.00), 0.88 (0.65–1.20) for CERAD-WL, 0.65 (0.48–0.88) for CERAD-DR, and 0.78 (0.53–1.15) for AF. Stratified analyses by sex showed that the above-mentioned associations were mainly found in men; however, the interaction with sex was not significant. Dose-response analysis showed that relationships between serum iron and cognitive impairment evaluated by DSST and CERAD-DR were linear, respectively.

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Section: Discussionmentioning

confidence: 99%

Association between serum iron concentrations and cognitive impairment in older adults aged 60 years and older: A dose-response analysis of National Health and Nutrition Examination Survey

Gong¹,

Song²,

Gu³

et al. 2021

PLoS ONE

Self Cite

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“…A mechanism research also supported the above results, showing that copper de ciency could induce a decrease in cytochrome oxidase levels, which leads to cognitive decline by interfering with energy expenditure and inducing apoptosis [47]. However, there are some con icting ndings [48,49]. Some scholars found a signi cant inverted U-shaped relationship between Cu and cognitive level in men and Cu was positively associated with cognition up to about 100 μg/dL, above which cognitive levels declined as Cu levels increase [50].…”

Section: Discussionmentioning

confidence: 70%

Multi-element Exposure and Cognitive Function in Rural Elderly Chinese

Duan,

Su,

et al. 2023

Biol Trace Elem Res

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To evaluate the association between combined exposure of selenium (Se) and other elements and cognitive function in older adults. MethodsA cross-sectional study involving 416 rural older adults aged 60 or older was conducted in four areas with different soil Se levels in Enshi county, China. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine whole blood Se, copper (Cu), iron (Fe), zinc (Zn), calcium (Ca), magnesium (Mg), cadmium (Cd), arsenic (As) and lead (Pb) concentration. Nine standard cognitive tests were applied to assess cognitive function. Analysis of covariance (ANCOVA) and generalized linear models (GLM) were used to determine the association between elements exposure and cognitive function. ResultsThe results of Lasso regression show that Se, Cu, Fe, Zn, Ca and Pb were independently identi ed to be associated with cognition. ANCOVA and GLM consistently indicated that Se and Ca were related to cognitive function. The multi-element model incorporating these selected six elements showed higher composite Z scores of 0.32 (95%CI: 0.087 to 0.533) for log-transformed Se (p < 0.05), 0.75 (95%CI: 0.007 to 1.493) for log-transformed Cu (p = 0.048) and a lower score of 0.67 (95%CI: -1.263 to -0.083) for logtransformed Ca (p < 0.05). Moreover, Se can antagonize the negative effect of Ca on cognitive function (p for interaction = 0.031). ConclusionOur ndings suggested that higher Se and Cu level were associated with better cognitive function in the elderly, and blood Se can antagonize the cognitive damage of blood Ca.

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“…[8,9] Analysis of data from National Health and Nutrition Examination Survey 2011 to 2014 showed that serum copper, although no association was found between the Digit Symbol Substitution Test and the Consortium to Establish a Registry for Alzheimer Disease (CERAD) Word Learning (CERAD-WL) and Delayed Recall (CERAD-DR) tests, was negatively associated with Animal Fluency scores, suggesting that serum copper is associated with executive function. [10] The imbalance of copper homeostasis in the brain is associated with cognitive decline in several neurodegenerative diseases. In Alzheimer disease (AD), copper binds directly to Aβ and promotes Aβ accumulation and oligomerization, which exacerbates ROS production and leads to oxidative neuronal damage.…”

Section: Copper Overload Affects Cognitive Functionmentioning

confidence: 99%

Section: Copper Overload Affects Cognitive Functionmentioning

confidence: 99%

Copper neurotoxicity: Induction of cognitive dysfunction: A review

Feng,

Zhao,

et al. 2023

Medicine

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Cognitive dysfunction occurs mainly in certain diseases and in the pathological process of aging. In addition to this, it is also widespread in patients undergoing anesthesia, surgery, and cancer chemotherapy. Neuroinflammation, oxidative stress, mitochondrial dysfunction, impaired synaptic plasticity, and lack of neurotrophic support are involved in copper-induced cognitive dysfunction. In addition, recent studies have found that copper mediates cuproptosis and adversely affects cognitive function. Cuproptosis is a copper-dependent, lipoylated mitochondrial protein-driven, non-apoptotic mode of regulated cell death, which provides us with new avenues for identifying and treating related diseases. However, the exact mechanism by which cuproptosis induces cognitive decline is still unclear, and this has attracted the interest of many researchers. In this paper, we analyzed the pathological mechanisms and therapeutic targets of copper-associated cognitive decline, mainly in the context of neurodegenerative diseases, psychiatric and psychological disorders, and diabetes mellitus.

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Serum Copper and Zinc Concentrations and Cognitive Impairment in Older Adults Aged 60 Years and Older

Cited by 10 publications

References 26 publications

Association between serum iron concentrations and cognitive impairment in older adults aged 60 years and older: A dose-response analysis of National Health and Nutrition Examination Survey

Association between serum iron concentrations and cognitive impairment in older adults aged 60 years and older: A dose-response analysis of National Health and Nutrition Examination Survey

Multi-element Exposure and Cognitive Function in Rural Elderly Chinese

Copper neurotoxicity: Induction of cognitive dysfunction: A review

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