Serum copper and zinc levels and the risk of oral cancer: A new insight based on large‐scale case–control study

Chen, Fa; Wang, Jing; Chen, Jinfa; Yan, Lingjun; Hu, Zhijian; Wu, Jun; Bao, Xiaodan; Lin, Li; Wang, Rui; Cai, Lin; Lin, Lisong; Qiu, Yu; Liu, Fengqiong; He, Baochang

doi:10.1111/odi.12957

Cited by 67 publications

(55 citation statements)

References 31 publications

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“…Also, laboratory test values, which are currently www.nature.com/scientificreports/ used for diagnosing HMs, deviated from the reference values in a highly significant way (P < 0.01, Table 1). The alteration of plasma metal concentrations (elevated for Cu and reduced for Zn) and laboratory test values in HM patients are consistent with reported data [5][6][7][8]25 .…”

Section: Resultssupporting

confidence: 92%

Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases

Hastuti

Costas‐Rodríguez

Matsunaga

et al. 2020

Sci Rep

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We have examined potential changes in the isotopic compositions of Fe, Cu and Zn (using multi-collector inductively coupled plasma-mass spectrometry) and the corresponding concentrations (using inductively coupled plasma-atomic emission spectrometry) in plasma from hematological malignancy (HM) patients and assessed their prognostic capability. Together with clinical laboratory test values, data were examined in view of a 5-years survival prediction. Plasma Cu and Zn isotope ratios and their concentrations were significantly different in HM patients compared to matched controls (P < 0.05). Both δ65Cu and δ66Zn values showed significant mortality hazard ratios (HRs) in HM. The group of patients with decreased δ65Cu and increased δ66Zn values showed significantly poorer survival from the early phase (HR 3.9; P = 0.001), forming a unique cohort not identified based on laboratory test values. Well-known prognostic factors for HM, such as the creatinine level, and anemia-related values were highly correlated with the δ66Zn value (P < 0.05). Time-dependent ROC curves based on the δ65Cu or δ66Zn value were similar to that based on the creatinine concentration (a well-known prognostic factor in HM), indicating that δ65Cu or δ66Zn values are useful for prognosis of HM. Variations in stable isotope ratios of essential mineral elements have thus been shown to reflect alterations in their homeostasis due to physiological changes in malignancies with higher sensitivity than concentrations do.

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Section: Resultssupporting

confidence: 92%

Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases

Hastuti

Costas‐Rodríguez

Matsunaga

et al. 2020

Sci Rep

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“…A similar approach was performed in patients with thyroid cancer 24,25 and breast cancer [26][27][28] . Other studies in head and neck cancer patients have analyzed the levels of some trace elements in the blood [11][12][13][14][15][16][17][18][19] , hair or nails 15,17,20,21 and in saliva 22,23 . It is worth mentioning that we found few studies that analyzed trace elements in the tumor tissue, these being in thyroid or breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Absent 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1.000 0 (0.0) 0 (0.0) 1.000 (0.0) 0 (0.0) 1.000 www.nature.com/scientificreports www.nature.com/scientificreports/ for oral cancer, even when adjusted for smoking and alcohol use 19,32 . In their study, Wozniak et al 21 analyzed the hair of patients with laryngeal cancers and found lower levels of zinc in smokers than in nonsmokers.…”

Section: Zincmentioning

confidence: 99%

“…In blood, for example, Bandeira et al 18 reported lower copper concentrations in patients with oral cancer, although these were nonsmokers. However, Chen et al 19 demonstrated the relationship between copper and zinc in the context of smoking; they observed higher concentrations of copper in smokers, which conferred a greater risk for oral cancer. Thus, it is worth mentioning that zinc and copper are important elements in head and neck cancer, and that their role in tumor tissues should be studied further.…”

Section: Zincmentioning

confidence: 99%

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Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival

Archanjo

Assis

Oliveira

et al. 2020

Sci Rep

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Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with ocScc, and performed a qualitative elemental characterization using the micro X-Ray fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in ocScc samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. the presence of chlorine in the samples was an independent protective factor against relapse (oR = 0.105, CI = 0.01-0.63) and for best disease-free survival (HR = 0.194, CI = 0.04-0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. in addition, chlorine proved to be important in the context of patient prognosis and survival. Squamous cell carcinoma (SCC) accounts for more than 90% of oral cancer cases 1,2 and mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. It may also be associated with human papillomavirus infection, genetic susceptibility and passive smoking exposure 1-5. Tobacco smoke itself, which contains hundreds of known toxic and carcinogenic molecules 6,7 , can induce DNA damage 8. Among these substances are several inorganic compounds, such as arsenic, calcium, chlorine, cobalt, copper, chromium, iron, magnesium, manganese, nickel, potassium, zinc and others 9,10. The analysis of trace elements is quite uncommon in the head and neck cancer field. Over the past two decades, a few studies have sought to verify the identity of these and other trace elements as risk or prognostic factors for head and neck cancer. Some authors verified the differences in the profile of trace elements in the blood (plasma/serum) of patients with or without head and neck cancer 11-19. Differences were also found in the analyses performed on the hair and nails of patients with head and neck cancer 15,17,20,21. However, in studies carried out

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“…C. Salivary ions: most of the researches explain excess and deficient levels of copper or zinc were significant correlation with oral cancer risk [85] D. Oxidative stress assessment: oxidative stress is the product of a discrepancy between oxidant factors and protective antioxidant systems; it may occur due to an excess of free radicals, or by the shrinking of the antioxidant systems.…”

Section: Classification Of Salivary Biomarkers For Oral Cancermentioning

confidence: 99%

Salivary Diagnostics in Oral Diseases

Bhat¹,

Bhat²

2019

Saliva and Salivary Diagnostics

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Common oral diseases like dental caries, periodontal diseases and oral cancer have major impact on quality of life. For prevention, treatment and prognosis, it is essential to measure the disease objectively and accurately in a quantitative manner. Quantification of biochemical or molecular specific products of cancers in serum or localized body juices can be one of the current methods of measuring oral diseases objectively. Salivary diagnostics has influenced several researchers and has been verified as an important tool in the diagnosis of many systemic conditions and prognosis of the disease. Developments in the field of molecular biology, salivary genomics and proteomics have directed to the detection of novel molecular markers for oral disease diagnosis, therapeutics and prognosis.

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Serum copper and zinc levels and the risk of oral cancer: A new insight based on large‐scale case–control study

Abstract: This preliminary study suggests that both serum excess and deficient levels of Cu or Zn were significant correlation with oral cancer risk, which may provide a new insight on the roles of serum Cu and Zn in oral cancer.

Cited by 67 publications

References 31 publications

Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases

Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases

Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival

Salivary Diagnostics in Oral Diseases

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