Serum corin is reduced and predicts adverse outcome in non-ST-elevation acute coronary syndrome

Abstract

Patients with non-ST-elevation ACS have lower serum corin levels than controls. Corin levels are lower in ACS patients who later experience MACE and thus might be predictor for MACE. This new putative biomarker may be useful, either alone or in combination with other biomarkers, for cardiovascular risk stratification assessment and outcome prediction in ACS patients.

Serum Soluble Corin Is Decreased in Stroke

“…The range of serum corin (373.4-2833.3 pg/mL) detected in nonhypertensive individuals in our controls was similar to that (296-2590 pg/mL) in the previous report. 13 Recently, some small sampled case-control studies have examined circulating soluble corin in some disease states, such as heart failure, 8 acute coronary syndrome, 9 osteoporosis, 17 and pregnant hypertension. 18 Corin concentration in the circulation was decreased in heart failure 8 and acute coronary syndrome.…”

“…18 Corin concentration in the circulation was decreased in heart failure 8 and acute coronary syndrome. 9 Given the connections between cardiac dysfunction and stroke, circulating corin is a candidate marker of stroke risk. However, to date, the association between circulating corin and stroke has not yet been studied in humans.…”

“…Our results were consistent with other studies that found that plasma corin was decreased in heart failure 8 and acute coronary syndrome. 9 However, the underlined mechanism was not clear. Also, it is not clear yet whether there is a causal relationship between the decreased serum levels of corin and stroke.…”

“…9 Given the connections between cardiac dysfunction and stroke, circulating corin might be a candidate marker of stroke risk. However, to date, the association between circulating corin and stroke has not yet been studied in humans.…”

Circulating Soluble Corin: A New Biomarker or Risk Factor for Age-Related Disorders

“…Circulating corin could be measured by enzyme-linked immunosorbent (ELISA) assays [6,[8][9][10]. To date, some small sampled case-control studies have examined circulating soluble coirn and found that corin in the circulation was decreased in osteoporosis [11], acute coronary syndrome [12], and heart failure [12] but increased in pregnant hypertension [13]. In addition, we previously found a significant and positive association of serum soluble corin with hypertension [14], obesity [15], hyperglycemia, and dyslipidemia (unpublished data) in a population of China.…”