Serum cortisol and testosterone levels in chronic central serous chorioretinopathy

Tufan, Hasan Ali; Gencer, Baran; Çömez, Arzu Taşkıran

doi:10.1007/s00417-012-2075-8

Cited by 33 publications

(31 citation statements)

References 16 publications

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“…[9] In the present study, 4% (1) with CSCR may have an impaired response to normal levels of serum cortisol and testosterone due to faulty choroidal/RPE response. [17] These findings are in conformation with the results of the present study. On the contrary, number of case reports of CSCR after systemic testosterone therapy shows indirect evidence of the role of testosterone in CSCR.…”

Section: Discussionsupporting

confidence: 92%

“…[28] suggested a weak association between cortisol and CSCR but this could be attributed to fairly low (six) number of subjects studied by them. [17] The visual acuity was significantly worse in the control group and was supposedly associated with more stress in the subjects which in turn should have led to increased blood cortisol but the presence of significantly high cortisol level in the CSCR patients, all the more strengthens the belief of glucocorticoids precipitating CSCR which could be either by their effect on the RPE or the choroidal vasculature. Also, increased cortisol acting via mineralocorticoid receptor (MR) may cause inappropriate expression of various channels viz.…”

Section: Discussionmentioning

confidence: 88%

“…Some previous studies have tried to constitute a link between testosterone and CSCR, but with only ambiguous results. [9,[14][15][16][17] The incidence of CSCR decreases as the age advances which correlates with the gradual decline in the total plasma testosterone levels with advancing age in older men, [18] which further strengthens the possibility of testosterone's involvement in the development of the disease.…”

Section: Introductionmentioning

confidence: 88%

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Endogenous Cortisol and Testosterone Level in Central Serous Chorioretinopathy: A Case Control Study

Sachdeva¹

2017

WJPR

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Central serous chorioretinopathy (CSCR) is characterized by anexudative neurosensory layer detachment of retina. Male gender, type-A personality, emotional stress, pregnancy, infections, hormonal regulatory factors and several immunological reactions have all been implicated in causing CSCR. Although several hypotheses have tried to establish a link between endocrinal abnormalities and CSCR, still none is able to explain the true etiopathogenesis of CSCR. This study was designed to estimate serum cortisol and testosterone levels in patients of CSCR and study their potential role in etiopathogenesis of the disease. In this study, 25 patients of CSCR satisfying the inclusion and exclusion criteria were enrolled as cases and 25 age and sex matched patients with an acute unilateral rhegmatogenous retinal detachment (RD) were enrolled as controls. Levels of serum cortisol and testosterone were estimated in both groups. Serum cortisol measurement was done twice, due to diurnal variation in its levels. Data analysis was done by Pearson's correlation analysis and independent student t-test. The 8:00 AM mean serum cortisol value in the cases (20.21 ± 4.86 μg/dl) was significantly (p = 0.046) higher than controls (17.74 ± 3.53 μg/dl). Although the 11:00 PM mean serum cortisol value of cases (8.13 ± 3.52 μg/dl)

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 88%

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Endogenous Cortisol and Testosterone Level in Central Serous Chorioretinopathy: A Case Control Study

Sachdeva¹

2017

WJPR

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“…In fact, several studies have shown that elevated serum testosterone is not universally present in cases of CSCR. 4,7,43 However, our experience suggests inquiring about the testosterone therapy in patients with CSCR, and in some cases, adjusting or stopping therapy may be appropriate.…”

Section: Discussionmentioning

confidence: 99%

Central Serous Chorioretinopathy in Patients Receiving Exogenous Testosterone Therapy

Nudleman

Witmer

Kiss

et al. 2014

Retina

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“…Serum cortisol levels were determined with the chemiluminescent immunassay method (IMMULITE® 2000 Xpi Immunoassay System, Siemens Healthcare Diagnostics). The normal range of reference serum cortisol level was determined as between five and 25 μg/dl …”

Section: Methodsmentioning

confidence: 99%

Correlation of choroidal thickness with serum cortisol level

Karahan¹,

Zengin

Aydin³

et al. 2015

Clinical and Experimental Optometry

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Background:The aim was to investigate the correlation of serum cortisol level with choroidal thickness. Methods: Sixty-six healthy volunteers had no visual complaints or history of ocular disease. Subfoveal choroidal thickness at the foveal centre was measured with spectral domain optical coherence tomography (SD-OCT). Morning serum cortisol levels were obtained at 8:00 am immediately following the SD-OCT measurement. Measurements of only the right eyes were included in the study. Age, gender, axial length and spherical equivalent were noted. Correlation of choroidal thickness with age, gender, axial length, spherical equivalent and serum cortisol level were investigated with linear and multiple regression analysis. Results: Sixty-six eyes of 66 patients were evaluated. Mean age was 43.4 ± 3.6 years (range: 40 to 53 years), mean spherical equivalent was -0.15 D (range: -1.25 to +1.50 D), mean axial length was 23.2 mm (range; 22.0 to 23.7 mm), mean choroidal thickness was 317.9 ± 45.1 μm (range: 206 to 394 μm). Age and spherical equivalent were not significantly correlated with choroidal thickness. Axial length had a strong negative correlation with choroidal thickness (R

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Serum cortisol and testosterone levels in chronic central serous chorioretinopathy

Abstract: Serum cortisol and testosterone levels were within normal ranges and in patients with chronic CSC. The association between these hormones and chronic CSC might be weak.

Cited by 33 publications

References 16 publications

Endogenous Cortisol and Testosterone Level in Central Serous Chorioretinopathy: A Case Control Study

Endogenous Cortisol and Testosterone Level in Central Serous Chorioretinopathy: A Case Control Study

Central Serous Chorioretinopathy in Patients Receiving Exogenous Testosterone Therapy

Correlation of choroidal thickness with serum cortisol level

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