Serum CRP Levels in Pre-Dialysis Patients

Razeghi, Effat; Parkhideh, Sayeh; Ahmadi, Farrokhlagha; Khashayar, Patricia

doi:10.1080/08860220701810539

Cited by 15 publications

(9 citation statements)

References 28 publications

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“…In another observational study, ferritin <800 ng/mL in incident dialysis patients was associated with lower mortality risk after iron supplementation [16]. Recently published guidelines recommended considering iron administration in dialysis patients with ferritin ≤500 ng/mL for safety [4, 20]. In the 6-week extension study of Dialysis Patients’ Response to IV Iron with Elevated Ferritin, a rise in ferritin <1,200 ng/mL by IV iron was beneficial in maintaining hemoglobin levels and keeping ESA use down, but survival outcomes were not evaluated due to the short study period [21].…”

Section: Discussionmentioning

confidence: 99%

Serum Ferritin Variations and Mortality in Incident Hemodialysis Patients

et al. 2017

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Background: Higher serum ferritin levels may be influenced by iron use and inflammation, and are associated with higher mortality in hemodialysis (HD) patients. We hypothesized that a major rise in serum ferritin is associated with a higher risk of mortality, irrespective of baseline serum ferritin in incident HD patients. Methods: In a cohort of 93,979 incident HD patients between 2007 and 2011, we examined the association of change in serum ferritin from the baseline patient quarter (first 91 days from dialysis start) to the subsequent quarter with mortality. Multivariable adjustments were done for case-mix and markers of the malnutrition, and inflammation complex and intravenous iron dose. Change in serum ferritin was stratified into 5 groups: <-400, -400 to <-100, -100 to <100, 100 to <400, and ≥400 ng/mL/quarter. Results: The median change in serum ferritin was 89 ng/mL/quarter (interquartile range -55 to 266 ng/mL/quarter). Compared to stable serum ferritin (-100 to <100 ng/mL/quarter), a major rise (≥400 ng/mL/quarter) was associated with higher all-cause mortality (hazard ratio [95% CI] 1.07 [0.99-1.15], 1.17 [1.09-1.24], 1.26 [1.12-1.41], and 1.49 [1.27-1.76] according to baseline serum ferritin: <200, 200 to <500, 500 to <800, and ≥800 ng/mL in adjusted models, respectively. The mortality risk associated with a rise in serum ferritin was robust, irrespective of intravenous iron use. Conclusions: During the first 6-months after HD initiation, a major rise in serum ferritin in those with a baseline ferritin ≥200 ng/mL and even a slight rise in serum ferritin in those with a baseline ferritin ≥800 ng/mL are associated with higher mortality.

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Section: Discussionmentioning

confidence: 99%

Serum Ferritin Variations and Mortality in Incident Hemodialysis Patients

et al. 2017

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“…28,29 Creactive protein and serum albumin are markers of inflammation and independent risk factors for all-cause mortality in CKD patients. 10 Serum albumin may therefore serve as an alternative to CRP in assessing cardiovascular event risk in CKD patients in resource poor countries like Nigeria because of its comparatively low cost.…”

Section: Discussionmentioning

confidence: 99%

Serum C-reactive protein levels in pre-dialysis chronic kidney disease patients in southern Nigeria

Adejumo¹,

Okaka²,

Okwuonu³

et al. 2016

Ghana Medical Journal

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SUMMARYBackground: Cardiovascular disease is the major cause of hospitalization and mortality in chronic kidney disease (CKD). C-reactive protein (CRP) is a marker of cardiovascular disease and predictor of mortality in CKD patients. CKD patients with elevated CRP should be identified early with institution of measures to treat cardiovascular risk factors in order to reduce attendant mortality. Aims: Determination of serum CRP levels in CKD patients and associated factors. Methods: This was a case-control study involving 80 consecutive CKD patients and 40 control subjects without CKD. Data obtained from participants included demographics, body mass index (BMI), and aetiology of CKD. Serum CRP levels, albumin, creatinine and lipid profile were determined. Cases and controls were compared. P values <0.05 were taken as significant Results: The mean age of the CKD subjects was 49.09±16.85 years. The median CRP value was significantly higher in the CKD group compared to controls (p=<0.001). Low, average and high cardiovascular event risk according to CRP values were present in 51(63.8%), 13(16.2%) and 16(20%) of the CKD patients respectively. Cardiovascular event risk was significantly higher in CKD subjects (p=<0.001). Serum creatinine, BMI, triglyceride and atherogenic index of plasma correlated positively with CRP. Estimated glomerular filtration rate (eGFR), high density lipoprotein-cholesterol and albumin correlated negatively with CRP. Elevated serum CRP was significantly predicted by low eGFR and high BMI on multivariate analysis. Conclusion: Chronic kidney disease patients have increased cardiovascular event risk. Interventions aimed at reducing weight and treating dyslipidaemia should be instituted early in order to reduce this risk.

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“…2 Approximately 30-50% of patients with ESRD have elevated serum level of C-reactive protein (CRP), a marker of systemic inflammation. 3,4 Investigators found that mortality caused by cardiovascular diseases in hemodialysis patients has a direct relation with high levels of CRP. 5 Furthermore, inflammation is also an important risk factor for complications in patients with pulmonary disease as well as in patient with ESRD.…”

Section: Introductionmentioning

confidence: 99%

Relation between Pulmonary Function and Inflammatory Biomarkers in Hemodialysis Patients

Razeghi

Pazoki²,

Ahmadi³

et al. 2011

Renal Failure

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The purpose of our study was to investigate the relationship between pulmonary function and serum levels of C-reactive protein (CRP), ferritin, albumin, and erythrocyte sedimentation rate, as inflammatory biomarkers, in hemodialysis patients. Ninety-eight patients, who were dialyzed at least for 3 months, were included in this study. Patients' blood samples were collected and pulmonary function tests, forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and peak expiratory flow (PEF) were measured and expressed as the %predicted using appropriate normal values for the patients' sex, age, and height (%FVC, %FEV1, and %PEF), at the same time. The patients with CRP ≥ 10 µg/mL were significantly older and had lower values of %FEV1, %FVC and %PEF (p = 0.006, p = 0.001, and p = 0.016, respectively); whereas just %FEV1 (p = 0.025) and %FVC (p = 0.009) had significant differences between the patients with ferritin ≥ 100 µg/L and other patients. However, no other significant differences were found between inflammatory biomarkers and the pulmonary function tests. We concluded that inflammation has a close relation with pulmonary dysfunction in hemodialysis patients.

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Serum CRP Levels in Pre-Dialysis Patients

Cited by 15 publications

References 28 publications

Serum Ferritin Variations and Mortality in Incident Hemodialysis Patients

Serum Ferritin Variations and Mortality in Incident Hemodialysis Patients

Serum C-reactive protein levels in pre-dialysis chronic kidney disease patients in southern Nigeria

Relation between Pulmonary Function and Inflammatory Biomarkers in Hemodialysis Patients

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