Serum CXCL9 and CCL17 as biomarkers of declining pulmonary function in chronic bird-related hypersensitivity pneumonitis

Nukui, Yoshihisa; Yamana, Takashi; Masuo, Masahiro; Tateishi, Tomoya; Kishino, Mitsuhiro; Tateishi, Ukihide; Tomita, Makoto; Hasegawa, Toshifumi; Aritsu, Takashi; Miyazaki, Yasunari

doi:10.1371/journal.pone.0220462

Cited by 27 publications

(24 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eosinophil is one of the Type 2 immune components. As previously reported, T2 immunity is activated in some ILD patients [30,31]. Among the patients in this study, EOP ratios were within normal ranges both before and after treatment.…”

Section: Discussionsupporting

confidence: 85%

The Difference Between SP-A and KL-6 Levels Responses for Treatment of Interstitial Lung Disease 

Zheng¹,

Zheng²,

Hasegawa³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background The highly variable clinical course of interstitial lung disease (ILD) makes it difficult to determine patients’ prognoses. Serum surfactant protein-A (SP-A) and Krebs von den Lungen-6 (KL-6) were known biomarkers as a monitor of the prognoses. However, the clinical or pathophysiological differences of those biomarkers are not well evaluated. Therefore, through the comparison of the changes of SP-A and KL-6 levels before and after treatment, we investigated the clinical or pathophysiological differences which are embodied by those markers. Methods This study included retrospective data for 71 patients treated for ILD at the First Affiliated Hospital of Guangzhou Medical University between August 2015 and September 2019. Serum SP-A and KL-6 levels were measured before and after treatment. The patients were followed for at least 3 months. Results Changes in the serum biomarkers (Delta SP-A and Delta KL-6) were significantly correlated (rS = 0.482, P < 0.001); Delta SP-A and Delta KL-6 were inversely correlated with changes in pulmonary function (P < 0.05). In a cluster analysis of delta SP-A and KL-6 levels, patients were classified into three groups. In the cluster analysis, in the group in which only SP-A levels decreased after treatment, 50.0% of patients recovered respiratory function and had a significant reduction of serum LDH levels.Conclusions Reduced serum SP-A and/or KL-6 levels were associated with improved lung function in patients with ILD. However, there were patients who showed only a reduction of SP-A levels after treatment. Thus, for proper disease monitoring, measuring both markers are important.

show abstract

Section: Discussionsupporting

confidence: 85%

The Difference Between SP-A and KL-6 Levels Responses for Treatment of Interstitial Lung Disease 

Zheng¹,

Zheng²,

Hasegawa³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…High-sensitivity CRP previously has been found to be elevated in HP in other bivariate analyses [33,34]. Although we did not find as association with KL-6, this has been observed in in other studies of HP [33][34][35]. Estimated alveolar NO differed statistically in bivariate analysis, but not in multivariate modelling.…”

Section: Discussioncontrasting

confidence: 70%

Occupationversusenvironmental factors in hypersensitivity pneumonitis: population attributable fraction

et al. 2020

View full text Add to dashboard Cite

BackgroundDespite well-documented case series of hypersensitivity pneumonitis (HP), epidemiological data delineating relative contributions of risk factors are sparse. To address this, we estimated HP risk in a case-referent study of occupational and nonoccupational exposures.MethodsWe recruited cases of HP by ICD-9 codes from an integrated healthcare delivery system (IHCDS) and a tertiary medical care centre. We drew referents, matched for age and sex, from the IHCDS. Participants underwent comprehensive, structured telephone interviews eliciting details of occupational and home environmental exposures. We employed a hierarchical analytic approach for data reduction based on the false discovery rate method within clusters of exposures. We measured lung function and selected biomarkers in a subset of participants. We used multivariate logistic regression to estimate exposure-associated odds ratios (ORs) and population attributable fractions (PAFs) for HP.ResultsWe analysed data for 192 HP cases (148 IHCDS; 44 tertiary care) and 229 referents. Occupational exposures combined more than doubled the odds of developing HP (OR 2.67; 95% CI 1.73–4.14) with a PAF of 34% (95% CI 21–46%); nonoccupational bird exposure also doubled the HP odds (OR 2.02; 95% CI 1.13–3.60), with a PAF of 12% (3–21%). Lung function and selected biomarkers did not substantively modify the risk estimates on the basis of questionnaire data alone.DiscussionIn a case-referent approach evaluating HP risk, identifiable exposures accounted, on an epidemiological basis, for approximately two in three cases of disease; conversely, for one in three, the risk factors for disease remained elusive.

show abstract

“…CXCL9 is an IFN-γ-inducible chemokine that is released by neutrophils, 25 , 34 and serve as Th1-type inflammatory markers in respiratory diseases. 35 , 36 When compared to healthy controls, CXCL9 concentrations were increased in COPD patients and positively correlated with markers of neutrophilic airway inflammation. 26 Fulkerson et al demonstrated that CXCL9 inhibits eosinophil migration to the lungs of allergen-induced mice.…”

Section: Discussionmentioning

confidence: 99%

High Blood Eosinophil and YKL-40 Levels, as Well as Low CXCL9 Levels, are Associated with Increased Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Peng

Fan

et al. 2021

COPD

View full text Add to dashboard Cite

Background Readmission after hospital discharge is common among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Predictive biomarkers of readmission would facilitate stratification strategies and individualized prognosis. Therefore, this study aimed to investigate the utility of type 2 biomarkers (eosinophils, periostin, and YKL-40) and a type 1 biomarker (CXCL9) in predicting readmission events in patients with AECOPD. Methods This is a prospective observational study design. Blood levels of eosinophils, periostin, YKL-40, and CXCL9 were measured at admission. The clinical outcomes were 12-month COPD-related readmission, time to COPD-related readmission, and number of 12-month COPD-related readmissions. These outcomes were analyzed using logistic and Cox regression models and Spearman’s rank test. Results A total of 123 patients were included, of whom 51 had experienced at least one readmission for AECOPD. High levels of eosinophils (≥200 cells/μL or 2% of the total white blood cell count, adjusted odds ratio [aOR] =3.138, P =0.009) and YKL-40 (≥14.5 ng/mL, aOR =2.840, P =0.015), as well as low CXCL9 levels (≤30.1 ng/mL, aOR =2.551, P =0.028), were associated with an increased COPD-related readmission. The highest relative readmission rate was observed in patients with both high eosinophil and YKL-40 levels. Moreover, high eosinophil and YKL-40 levels were associated with a shorter time to first COPD-related readmission and an increased number of 12-month COPD-related readmissions. Conclusion High blood eosinophil and YKL-40 levels, as well as low CXCL9 levels, have predictive utility for the 12-month COPD-related readmission rate. Using eosinophils and YKL-40 together allows more precise identification of patients at high risk of COPD-related readmission.

show abstract

Serum CXCL9 and CCL17 as biomarkers of declining pulmonary function in chronic bird-related hypersensitivity pneumonitis

Cited by 27 publications

References 34 publications

The Difference Between SP-A and KL-6 Levels Responses for Treatment of Interstitial Lung Disease

The Difference Between SP-A and KL-6 Levels Responses for Treatment of Interstitial Lung Disease

Occupationversusenvironmental factors in hypersensitivity pneumonitis: population attributable fraction

High Blood Eosinophil and YKL-40 Levels, as Well as Low CXCL9 Levels, are Associated with Increased Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Contact Info

Product

Resources

About

Serum CXCL9 and CCL17 as biomarkers of declining pulmonary function in chronic bird-related hypersensitivity pneumonitis

Cited by 27 publications

References 34 publications

The Difference Between SP-A and KL-6 Levels Responses for Treatment of Interstitial Lung Disease&nbsp;

The Difference Between SP-A and KL-6 Levels Responses for Treatment of Interstitial Lung Disease&nbsp;

Occupationversusenvironmental factors in hypersensitivity pneumonitis: population attributable fraction

High Blood Eosinophil and YKL-40 Levels, as Well as Low CXCL9 Levels, are Associated with Increased Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Contact Info

Product

Resources

About

The Difference Between SP-A and KL-6 Levels Responses for Treatment of Interstitial Lung Disease

The Difference Between SP-A and KL-6 Levels Responses for Treatment of Interstitial Lung Disease