Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment

Coll, Elisabeth; Botey, A; Álvarez, Luisa; Poch, Esteban; Quintó, Llorenç; Saurina, Ana; Vera, Manel; Piera, Carlos; Darnell, A

doi:10.1053/ajkd.2000.8237

Cited by 565 publications

(399 citation statements)

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“…Serum Cys-C levels have been proposed to be an ideal marker of the GFR (3), and these levels are not dependent on muscle mass (20). Therefore, the serum level of Cys-C may be a better marker of GFR than serum Cre (2,3).…”

Section: Discussionmentioning

confidence: 99%

Serum levels of cystatin C in elderly lung cancer patients

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Serum levels of cystatin C in elderly lung cancer patients

et al. 2011

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“…Cystatin C, a nonglycosylated basic protein produced at a constant rate by all nucleated cells, 85 is more easily interpretable than creatinine because a single reference range can be used for any child over 1 year of age. 86 Cystatin C is a more sensitive marker of mild renal impairment than creatinine, 87,88 and mild elevations are seen in preterm infants at 12 to 36 months of age compared with term control subjects.…”

Section: Figurementioning

confidence: 99%

Short-Term Gestation, Long-Term Risk: Prematurity and Chronic Kidney Disease

2013

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Thanks to remarkable advances in neonatal intensive care, infants who once had little chance for survival can now enter adulthood. Yet the consequences of premature birth or low birth weight (LBW) on nephrogenesis, final nephron number, and long-term kidney function are unclear. This review focuses on the theory, experimental evidence, and observational data that suggest an increased risk of chronic kidney disease (CKD) for infants born prematurely. Many premature and LBW infants begin life with an incomplete complement of immature nephrons. They are then exposed to a variety of external stressors that can hinder ongoing kidney development or cause additional nephron loss such as hemodynamic alterations, nephrotoxic medications, infections, and suboptimal nutrition. Acute kidney injury, in particular, may be a significant risk factor for the development of CKD. According to Brenner' s hypothesis, patients with decreased nephron number develop hyperfiltration that results in sodium retention, hypertension, nephron loss, and CKD due to secondary focal segmental glomerulosclerosis. Because the risk of CKD in premature and LBW infants has not been accurately determined, there are no evidence-based recommendations for screening or management. Yet with the first generation of infants from the surfactant era only now reaching adulthood, it is possible that there is already an unrecognized epidemic of CKD. We suggest individualized, risk-based assessments of premature and LBW infants due to the increased risk of CKD and call for additional research into the long-term risk for CKD these infants face.

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“…Serum CysC is a new and promising marker for kidney dysfunction (Coll et al 2000;Marwyne et al 2011;Moran et al 2008). Numerous studies had found CysC to be a better marker of GFR than creatinine.…”

Section: Discussionmentioning

confidence: 99%

“…CysC is a 122-amino acid that belongs to a family of potent, noncovalent, competitive inhibitors of mammalian lysosomal cysteine proteinases. Unlike serum creatinine, CysC has a constant rate of production independent of age, sex or muscle mass and may be a better marker for renal function (Coll et al 2000;Marwyne et al 2011;Moran et al 2008). Several recent publications have also demonstrated that CysC was superior to serum creatinine for prediction of all-cause mortality, cardiovascular events and incident congestive heart failure in elderly communitybased cohorts (Joachim et al 2007).…”

Section: Introductionmentioning

confidence: 99%