Serum Cystatin C as a Potential Marker for Glomerular Filtration Rate in Patients with Cholangiocarcinoma

Ciin, Mang Ngaih; Proungvitaya, Tanakorn; Limpaiboon, Temduang; Roytrakul, Sittiruk; Cha’on, Ubon; Tummanatsakun, Doungdean; Proungvitaya, Siriporn

doi:10.18502/ijhoscr.v14i3.3723

Cited by 4 publications

(6 citation statements)

References 32 publications

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“…Both the study's CKD patients and those undergoing dialysis exhibited albumin synthesis rates similar to individuals without hypoalbuminemia, challenging the notion that renal disease invariably leads to decreased albumin levels (18). These findings align with other research suggesting well-maintained nutritional status among patients, as evidenced by elevated cystatin C levels compared to controls (19). In summary, the study established a positive association between cystatin C and serum creatinine levels, with increased cystatin C serving as an indicator of good nutritional status and a prognostic tool for patients undergoing dialysis.…”

Section: Discussionsupporting

confidence: 65%

“…Given the variations in plasma cystatin C levels reported in the literature across different populations and demographic factors, the study's findings should be interpreted with caution, considering potential variability by gender, age, and ethnicity. It is recommended that subsequent research expands on these findings, incorporating a more extended study duration, repeated measures, and a broader range of clinical parameters to enhance the understanding and clinical utility of cystatin C as a biomarker in kidney disease management (13)(14)(15)(16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

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Elevating Precision in Kidney Injury Management: Unraveling the Impact of Serum Cystatin C Levels – A Cohort Study in Lahore Hospitals

Rafiq,

Fatima,

Khaliq

et al. 2024

JHRR

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Background: Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) pose significant challenges in clinical diagnostics due to late presentation and the influence of non-renal factors on traditional biomarkers. Serum creatinine, while commonly used, lacks sensitivity in early-stage kidney dysfunction due to its delayed elevation post-reduction in glomerular filtration rate (GFR). Serum cystatin C, on the other hand, is not influenced by muscle mass, age, gender, or ethnicity, and thus presents as a potential early biomarker for kidney injury. Objective: The objective of this study was to evaluate the efficacy of serum cystatin C compared to serum creatinine in early detection of renal dysfunction in AKI patients, assessing its correlation with renal decline and potential as a predictor for patient outcomes. Methods: In a cohort study over two years at a tertiary care hospital, 200 healthy individuals and 130 AKI patients were assessed. Serum cystatin C and creatinine levels were measured using ELISA and chemiluminescent immunoassay (CLIA) respectively. Demographics, clinical statistics, and Pearson correlation coefficients were calculated, followed by multiple logistic regression analyses for GFR. Statistical significance was established at P<0.001. Results: Results indicated that in the early phase of AKI, 56.2% of patients had normal serum creatinine levels, whereas serum cystatin C levels were elevated in all patients. The Pearson Correlation Coefficient between serum creatinine and cystatin C was significant (<0.01). Multiple logistic regression revealed cystatin C-based GFR was a more reflective indicator of declining GFR than creatinine-based GFR (P<0.001). Conclusion: Serum cystatin C is a superior biomarker to serum creatinine for early detection of kidney dysfunction in AKI patients, facilitating earlier and potentially more effective therapeutic interventions. This finding could lead to significant improvements in patient prognosis and the management of kidney disease.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Elevating Precision in Kidney Injury Management: Unraveling the Impact of Serum Cystatin C Levels – A Cohort Study in Lahore Hospitals

Rafiq,

Fatima,

Khaliq

et al. 2024

JHRR

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“…Sample size calculation. To determine the sample size required to establish the prognostic score, the preliminary study was performed using iCCA patients' data (n=82) from our previous study (22). The sample size was calculated using the G*Power program (version 3.1.9.7, the G*Power team, Heinrich Heine University, Düsseldorf, Germany) (23).…”

Section: Methodsmentioning

confidence: 99%

Development of a Prognostic Score for Cholangiocarcinoma Patients Using a Combination of Biochemical Parameters

Min-Oo¹,

Aung²,

Wongwattanakul³

et al. 2023

In Vivo

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Background/Aim: Prognosis of cholangiocarcinoma (CCA), especially of intrahepatic CCA (iCCA), is poor primarily due to difficulties in earlier diagnosis. Since the majority of iCCA patients are elders, their prognosis cannot be correctly predicted by pathological features and/or resection status alone. Consideration for comorbidity and/or risks of subclinical diseases at diagnosis is critically necessary for the prediction of prognosis of iCCA patients. This study aimed to develop a simple but reliable scoring system for prognosis of iCCA patients at the time of diagnosis. Patients and Methods: Serum samples from 152 iCCA patients were collected, and four commonly used biochemical markers, serum aspartate aminotransferase, alkaline phosphatase, cystatin C and creatinine-based estimated glomerular filtration rate were measured. Then, the values of individual patients were scored as 0, 1, and 2 (low, medium, and high) by tertiles or clinically relevant cutoff points and summed to construct a prognostic score with a range between 0 to 8. Results: Patients with high scores of 2-4 and 5-8 exhibited significantly shorter survival times compared to those with low scores of 0-1 p<0.001). Cox regression analysis suggested that the score could be an independent predictor for the survival of iCCA patients. The odds of advanced tumor stage in high score iCCA patients (2)(3)(4), respectively. This scoring system allowed further stratification of death rates per 100 person-years of iCCA patients. Conclusion:The ability of such a simple scoring system to discriminate risk might be helpful for iCCA patients to determine therapeutic programs at the time of diagnosis.

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“…Therefore, using serum Cys-C based equations may reflect the "true" GFR in obese patients 24 . Also, higher values of GFR have been found with CKD-EPI creatinine in cancer patients 25 .…”

Section: Discussionmentioning

confidence: 93%

Comparison of creatinine, cystatin, CKD-EPI cystatin C, CKD-EPI creatinine and MDRD equations in estimating glomerular filtration rate in patients with nephrotic syndrome

Koçak¹,

Kayalar²

2021

Cumhuriyet Medical Journal

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It's recommended to use equations such as Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) by using creatinine level in estimating glomerular filtration rate (GFR). Here, we aimed to compare serum cystatin-C (Cys-C) and Cys-C based equations with creatinine and creatinine based equations in patients with chronic kidney disease (CKD) and nephrotic syndrome (NS). Method: A total of 142 patients with CKD (30 with NS and 112 without NS) followed in the nephrology outpatient clinic were included into the study. The patients were divided into two groups as NS (n=30) and non-NS (n=112). Results: Out of 142 patients, 74 (52.1%) were male. Mean age of the patients was 51.94 ± 14.23 years (17-80). There was no significant difference in terms of age, gender and diabetes prevalence rates between the patients with NS and non-NS (p>0.05). Proteinuria was 6300.77 ± 3192.47 grams in the NS group and 1112.09 ±1004.36 grams in the non-NS group (p=0.001). Total cholesterol and LDL values were found to be significantly higher in patients with NS (p=0.033 and p=0.017, respectively). While there was no difference in serum creatinine level between the two groups, the Cys-C value in the NS group was found to be significantly higher than those of non-NS group (2.44 ± 0.94 vs 2.00 ± 0.99; p=0.014). CKD-EPI-CysC GFR and CKD-EPI Cr-CysC values were found to be significantly lower in the NS group than in the non-NS group (p=0.025, p=0.042, respectively). No significant difference was found between the two groups in CKD-EPI-Cr, MDRD formula and creatinine clearance. Conclusions: Formulas based on alternative markers such as Cys-C may be more advantageous for the correct estimation of GFR. In this study, we showed that CKD-EPI-CysC and CKD-EPI Cr-CysC are better in detecting CKD than others in the evaluation of renal functions in NS.

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Serum Cystatin C as a Potential Marker for Glomerular Filtration Rate in Patients with Cholangiocarcinoma

Cited by 4 publications

References 32 publications

Elevating Precision in Kidney Injury Management: Unraveling the Impact of Serum Cystatin C Levels – A Cohort Study in Lahore Hospitals

Elevating Precision in Kidney Injury Management: Unraveling the Impact of Serum Cystatin C Levels – A Cohort Study in Lahore Hospitals

Development of a Prognostic Score for Cholangiocarcinoma Patients Using a Combination of Biochemical Parameters

Comparison of creatinine, cystatin, CKD-EPI cystatin C, CKD-EPI creatinine and MDRD equations in estimating glomerular filtration rate in patients with nephrotic syndrome

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