Serum cystatin C during 30 postnatal days is dependent on the postconceptional age in neonates

Lee, Ji‐Hyun; Hahn, Won‐Ho; Ahn, Jaeouk; Chang, Jiyoung; Bae, Chong‐Woo

doi:10.1007/s00467-013-2429-4

Cited by 30 publications

(30 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Je-Hyan Lee et al [20] have made a significant contribution towards closing the knowledge gap of cystatin C concentrations in the first month of life, despite the many limitations of their study. Further work and a coordinated effort across the globe is needed to develop a useful tool using the Box-Cox transformation of normal cystatin C data in infants to generate appropriate LMS charts for the calculation of age-independent percentiles that will enable accurate determination of the cystatin C percentiles based on postconceptional and postnatal age.…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, when all groups were analyzed separately and longitudinally, the cystatin C values can be seen to have increased slightly (Fig. 1, derived from Table 2 in the article of Je-Hyan Lee et al [20]). The slope of the regression line of the averages increases significantly in the extremely preterm group.…”

Section: Serum Cystatin C In the First 30 Postnatal Days In Neonatesmentioning

confidence: 93%

“…The undersigned call for a multicenter collaboration to identify all infant cystatin C measurements in healthy children or children without any obvious disease or nephrotoxic medication or dehydration to generate these percentiles. Some of the measurements obtained by Je-Hyan Lee et al [20] can be included. We suggest that the International Pediatric Nephrology Association could play a key role in coordinating such efforts.…”

Section: Future Directionsmentioning

confidence: 99%

“…However, pediatric reference intervals of cystatin C beyond 72 h postpartum to 1 year of age have to date lacked the necessary high resolution of post-conceptual age that is necessary to assess the rapid ontogeny of nephron recruitment in the first few months of life [3,5,18,19]. In that context, we are delighted to see an important attempt at closing the knowledge gap, at least for the first 30 days of life, in the study of Ji-Hyun Lee and coworkers in this edition of Pediatric Nephrology [20].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cystatin C adaptation in the first month of life

Filler

Lepage

2013

Pediatr Nephrol

View full text Add to dashboard Cite

Je-Hyan Lee et al. have published a study on cystatin C concentrations in the first 30 days of life in 127 pre-term and 119 term neonates in this edition of Pediatric Nephrology, thereby closing a knowledge gap of detailed cystatin C concentrations beyond 72 h of life by day of life and by post-conceptional age. While the study objective has merit and a large number of measurements were included, there are some methodological limitations that bring the validity of the data into question as pure reference intervals for children up to 1 month of age, mostly because of the inclusion of patients that potentially could have an impaired glomerular filtration rate (GFR), for instance due to exposure to nephrotoxic drugs. We discuss the strengths and weaknesses of the study and outline an approach to definitely close this knowledge gap. We call for a worldwide collaboration to use Box-Cox transformations similar to the methodology used with growth charts to calculate ageindependent z-scores and percentiles of neonatal and infant markers of GFR. This could also lead to better definitions of acute kidney injury in infants if GFR markers cross the percentiles based on post-conceptional or chronological age.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Serum Cystatin C In the First 30 Postnatal Days In Neonatesmentioning

confidence: 93%

Section: Future Directionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cystatin C adaptation in the first month of life

Filler

Lepage

2013

Pediatr Nephrol

View full text Add to dashboard Cite

show abstract

“…Currently, the most reliable eGFR formulae in children use CysC alone or in combination with Cr and/or urea [23]. Je-Hyan Lee et al [24] recently made a significant contribution to advancing our knowledge of CysC concentrations in the first month of life [25]. A suitable formula for calculating eGFR based on neonatal CysC has, however, been elusive.…”

Section: Introductionmentioning

confidence: 98%

A step forward towards accurately assessing glomerular filtration rate in newborns

Filler

2015

Pediatr Nephrol

View full text Add to dashboard Cite

In this edition of Pediatric Nephrology, Milena Treiber and colleagues have published a study on cystatin C (CysC) concentrations in relation to renal volumetry in 50 small-for-gestational age (SGA) and 50 appropriate-for-gestational age (AGA) neonates, deriving a new formula for estimating neonatal glomerular filtration rate (GFR). The study builds on previous work which established that renal volumetry together with CysC blood levels is a superior method for establishing GFR in term and pre-term newborns [The Journal of Pediatrics (2014) 164:1026-1031.e2]. Treiber et al. use the expected difference between SGA and AGA renal volumes to document the superiority of their new formula, which is based on total renal volume, CysC and body surface area, but does not incorporate gold-standard inulin clearance. Treiber et al.'s study adds new knowledge to the field that will hopefully improve the safety of renally excreted critical dose drugs in the newborn period. This editorial discusses the strengths and limitations of the current study.

show abstract