Serum Cystatin C in Relation to Fat Mass Loss After Bariatric Surgery"

Śledziński, Tomasz; Proczko-Markuszewska, Monika; Kaska, Łukasz; Stefaniak, Tomasz; Świerczyński, Julian

doi:10.2478/v10035-012-0033-0

Cited by 10 publications

(8 citation statements)

References 33 publications

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“…The concentrations of arginine and glycine, which are precursors of creatinine, were elevated after surgery, so the decrease of serum creatinine level is rather an effect of improvement of kidney function that is observed after bariatric surgery [51].…”

Section: Discussionmentioning

confidence: 99%

One Anastomosis Gastric Bypass Reconstitutes the Appropriate Profile of Serum Amino Acids in Patients with Morbid Obesity

Haliński

Pakiet

Jabłońska

et al. 2019

JCM

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Bariatric surgery leads to metabolic benefits in patients with obesity, but their mechanisms are not well understood. The appropriate composition of serum amino acids (AA) is important for sufficient supply of these components into various tissues and organs. Obesity leads to alterations in serum AA concentrations. The aim of this study was to examine the effect of one anastomosis gastric bypass (OAGB), a promising type of bariatric surgery, on serum AA concentrations, which were assayed by LC-MS in serum of 46 bariatric patients prior to and 6–9 months after OAGB, as well as in 30 lean control subjects. The results were analyzed by principle components analysis and metabolic pathway analysis. PCA analysis showed that OAGB led to normalization of serum AA concentrations of patients with obesity to a pattern similar to the control subjects, and the concentrations of essential AA remained decreased after OAGB. Changes of individual AA and their associated metabolic pathways were also presented. OAGB caused normalization of the AA profile, which may contribute to improvement of glucose homeostasis and reduction of cardiovascular risk. Considering decreased essential AA concentrations after OAGB, increased intake of high protein food should be recommended to the patients after this type of bariatric surgery.

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Section: Discussionmentioning

confidence: 99%

One Anastomosis Gastric Bypass Reconstitutes the Appropriate Profile of Serum Amino Acids in Patients with Morbid Obesity

Haliński

Pakiet

Jabłońska

et al. 2019

JCM

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“…It is an endogenous filtration marker that is being considered as a potential substitution of serum creatinine in the evaluation of renal capacity, predominantly for the identification of little changes in the glomerular filtration rate, since it is asserted to be free of age, sex, skeletal bulk and protein consumption [ 5 ]. Sledzinsk and others demonstrated that human obesity is associated with an abnormality in cystatin-C value, and that fat tissue elevated serum cystatin-C in obese subjects [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Obesity Related Metabolic Disorders and Risk of Renal Disease: Impact of Hypocaloric Diet and Avena Sativa Supplement

Shebini¹,

Moaty²,

Fouad³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:The recognition of the complications of obesity in various organs and systems should make clinicians and dietitians aware of the importance of early strategies to fight obesity in all age groups.AIM:The objective of this study was to evaluate the early effect of using Avena sativa (oat) flour supplement compared to a hypocaloric diet in the management of obesity-related metabolic disorders.MATERIAL AND METHODS:Snack was prepared from wholemeal wheat flour (100% extraction) and oat flour. Chemical analysis of the raw materials and the formulae was carried out. 106 obese women with their mean body mass index were 37.73 ± 0.56 kg/m2 volunteered for 8 weeks period. They were divided into two groups; group (A), consumed hypocaloric diet supplemented by the prepared snack, while group (B) subjects followed the low caloric balanced diet. All patients were monitored clinically, anthropometrically, dietary 24 h recall and biochemically.RESULT:Data demonstrated significantly decreased in the mean levels of the anthropometric parameters. Group (A) showed a higher decrease in the waist circumference, WHR, body fat% and SBP; while in group (B) weight, BMI, chest circumference and DBP were the most affected parameters. The reduction in the biochemical parameters was higher in the group (A). At the baseline, high values of cystatin-C were found in both groups which may indicate early renal injury. At the end of the study, a significant reduction of the cystatin concentration was observed among both groups (-24.54 & -12.23%).CONCLUSION:The healthy effect of the dietary oat supplement on the reduction of central obesity, percentage body fat and different metabolic disorders criteria was confirmed than with hypocaloric diet.

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“…This association between cystatin C and WC remained significant even after the adjustment for confounding factors. On the other hand, some other studies (10)(11)(12)(13)(14)(15) failed to find the association between cystatin C and obesity-related parameters, thus rejecting the Sledziński et al (19) also reported significantly higher serum cystatin C concentrations in obese patients compared to non-obese subjects. However, decrease of body and fat mass after bariatric surgery resulted in improvement of cardiometabolic parameters (e.g., serum lipids, blood pressure, and insulin sensitivity), but surprisingly the mean postoperative serum cystatin C concentration was not significantly different from that before the surgery, suggesting that serum cystatin C concentration is not tightly associated with body and fat mass loss in obese patients.…”

Section: Discussionmentioning

confidence: 62%

Cystatin C in healthy middle-aged adults: A relationship with anthropometric and cardiometabolic parameters

Jovanović

Kavarić

Gligorovic-Barhanovic

et al. 2016

JHSCI

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Serum Cystatin C in Relation to Fat Mass Loss After Bariatric Surgery"

Cited by 10 publications

References 33 publications

One Anastomosis Gastric Bypass Reconstitutes the Appropriate Profile of Serum Amino Acids in Patients with Morbid Obesity

One Anastomosis Gastric Bypass Reconstitutes the Appropriate Profile of Serum Amino Acids in Patients with Morbid Obesity

Obesity Related Metabolic Disorders and Risk of Renal Disease: Impact of Hypocaloric Diet and Avena Sativa Supplement

Cystatin C in healthy middle-aged adults: A relationship with anthropometric and cardiometabolic parameters

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