Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions

Abstract

SummaryBackground: The aim of this study was to determine the level of serum cystatin C (CysC) in patients with Chronic Obstructive Pulmonary Disease (COPD) during exacerbation and stable periods and to investigate its potential diagnostic value and the relationship between CysC levels and the pulmonary function test (PFT). Methods: One hundred twenty-six patients with COPD (68 in stable periods, 58 during exacerbation periods) and 50 healthy subjects were included in the study. PFT, body mass index (BMI), white blood cell counts, C-reactive protein (CRP), serum urea and creatinine levels were evaluated in both groups of patients. CysC levels were measured in all participants. Results: Serum CysC levels were statistically higher in both COPD groups than the control group (p<0.001 for both) although there was no statistically significant difference between COPD groups (p>0.05). CysC levels showed negative correlation with forced expiratory volume in 1 second (FEV 1 ) and a positive correlation with C-reactive protein (CRP) levels in patients with stable COPD. There was a positive correlation between serum CysC levels and serum urea, creatinine, CRP levels in patients with COPD exacerbation (r=0.333, p=0.011; r=0.260, p=0.049; r=0.414, p<0.01 respectively). When stable COPD and control groups were evaluated, serum CysC had an area under the curve (AUC) in the receiver operating characteristic (ROC) curve of 0.951 (0.909-0.994 95% CI: p<0.001).

Utility of leucocytes, inflammatory markers and pancreatic enzymes as indicators of gangrenous cholecystitis

“…In addition, despite the substantial evidence for the association between NLR and adverse outcomes, the underlying mechanism is not well understood. Previous research showed that NLR was a highly sensitive predictor of outcomes in cholecystitis 14–16. For example, in a retrospective cohort including 632 patients who underwent cholecystectomy, NLR was an independent predictor of cholecystitis severity.…”

The association between cystatin C and COPD: a meta-analysis and systematic review

“…Nakajima et al [26] reported that serum levels of Cys C were significantly higher in COPD patients than control. Previous studies showed that inflammatory parameters such as interleukin-6, resistin, tumor necrosis factor, and CRP were significantly correlated with Cys C, suggesting that the elevation of Cys C was secondary to the inflammatory processes in the lung [31,38,50]. These all above cytokines have been found to be closely related to COPD, which indicated that elevated Cys C levels might be associated with pulmonary inflammation.…”

“…Recent studies indicate a possible link between Cys C and COPD [24][25][26][27][28]; however, the conclusion is not clear. Most studies have shown that serum Cys C levels are higher in the exacerbation group than stable COPD or healthy control [29,30], but Selder et al [31] find that serum Cys C levels are lower in exacerbation group than stable COPD. We performed this meta-analysis to clarify the associations between serum Cys C levels and COPD as well as COPD exacerbation.…”

Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis

“…Circulating WBCs and their classification counts will change, typically leading to lymphopenia and neutrophilia, in the presence of systemic inflammation (42,43). NLR is closely associated with most common inflammatory biomarkers, such as C-reactive protein and erythrocyte sedimentation rate (44)(45)(46)(47)(48)(49). A growing body of evidence suggests that NLR may act as excellent indicator of inflammation status in various diseases, such as Crohn's disease (49), cancer (50,51), infection (52,53), and rheumatic diseases (54)(55)(56).…”