Serum cytokine and chemokine profiles in patients with alopecia areata

Bilgiç, Özlem; Sivrikaya, Abdullah; Ünlü, Ali; Altinyazar, H. Cevdet

doi:10.3109/09546634.2015.1093591

Cited by 30 publications

(33 citation statements)

References 26 publications

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“…Levels of IL‐17A were similar between AA and PsA; however, a proportion of patients with PsA had a higher concentration. These data and data from others indicate that type 17 cytokines are altered in AA. Clinically, IL‐17A blockade has failed to demonstrate efficacy in AA .…”

Section: Discussionsupporting

confidence: 77%

“…A higher proportion of patients with patchy hair loss (SALT: S1 ≥ S4a) scored above 17). HADS scores were considered as no depression/anxiety (0-7), mild depression/anxiety (8-10), moderate depression/anxiety (11)(12)(13)(14) and severe depression/anxiety (15)(16)(17)(18)(19)(20).…”

Section: Depression and Alopecia Areatamentioning

confidence: 99%

“…IFN‐γ and interleukin (IL)‐15 are crucial for potentiating the activity of CD8 + T cells and natural killer cells in AA . Concentrations of circulating IL‐6, tumour necrosis factor (TNF)‐α, IL‐17A, IL‐21, IL‐22 and IL‐23 are elevated in patients with AA . In the skin, molecular profiling reveals dysregulation in cytokines associated with type 1 and type 2 inflammation, while also indicating altered expression of IL‐23 .…”

mentioning

confidence: 99%

“…9,13 Concentrations of circulating IL-6, tumour necrosis factor (TNF)-a, IL-17A, IL-21, IL-22 and IL-23 are elevated in patients with AA. [14][15][16][17] In the skin, molecular profiling reveals dysregulation in cytokines associated with type 1 and type 2 inflammation, while also indicating altered expression of IL-23. 18 These data and those based on other skin inflammatory diseases indicate the central role of cytokines in driving skin pathology.…”

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confidence: 99%

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Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity

et al. 2019

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Summary Background Alopecia areata (AA) is a common autoimmune disease, causing patchy hair loss that can progress to involve the entire scalp (totalis) or body (universalis). CD8+NKG2D+ T cells dominate hair follicle pathogenesis, but the specific mechanisms driving hair loss are not fully understood. Objectives To provide a detailed insight into the systemic cytokine signature associated with AA, and to assess the association between cytokines and depression. Methods We conducted multiplex analysis of plasma cytokines from patients with AA, patients with psoriatic arthritis (PsA) and healthy controls. We used the Hospital Anxiety and Depression Scale (HADS) to assess the occurrence of depression and anxiety in our cohort. Results Our analysis identified a systemic inflammatory signature associated with AA, characterized by elevated levels of interleukin (IL)‐17A, IL‐17F, IL‐21 and IL‐23 indicative of a type 17 immune response. Circulating levels of the type 2 cytokines IL‐33, IL‐31 and IL‐17E (IL‐25) were also significantly increased in AA. In comparison with PsA, AA was associated with higher levels of IL‐17F, IL‐17E and IL‐23. We hypothesized that circulating inflammatory cytokines may contribute to wider comorbidities associated with AA. Our assessment of psychiatric comorbidity in AA using HADS scores showed that 18% and 51% of people with AA experienced symptoms of depression and anxiety, respectively. Using linear regression modelling, we identified that levels of IL‐22 and IL‐17E are positively and significantly associated with depression. Conclusions Our data highlight changes in both type 17 and type 2 cytokines among people with AA, suggesting that complex systemic cytokine profiles may contribute both to the pathogenesis of AA and to the associated depression. What's already known about this topic? NKG2D+CD8+ T cells cause hair loss in alopecia areata (AA) but the immunological mechanisms underlying the disease are not fully understood. AA is associated with changes in levels of interleukin (IL)‐6, tumour necrosis factor‐α, IL‐1β and type 17 cytokines. Psychiatric comorbidity is common among people with AA. What does this study add? People with AA have increased plasma levels of the type 2 cytokines IL‐33, IL‐31 and IL‐17E (IL‐25), in addition to the type 17 cytokines IL‐17A, IL‐21, IL‐23 and IL‐17F. Levels of IL‐17E and IL‐22 positively predict depression score. What is the translational message? AA is associated with increased levels of multiple inflammatory cytokines, implicating both type 17‐ and type 2 immune pathways. Our data indicate that therapeutic strategies for treating AA may need to address the underlying type 17‐ and type 2 immune dysregulation, rather than focusing narrowly on the CD8+ T‐cell response. An immunological mechanism might contribute directly to the depression observed in people with AA.

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Section: Discussionsupporting

confidence: 77%

Section: Depression and Alopecia Areatamentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity

et al. 2019

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“…Bilgiç ve ark. Alopesi areata'lı hastaların serumlarında TNF-α, IL-6, IL-23, Th1-CXCL9, Th2-CCL17, CCL20, and CCL2 seviyelerinin kontrol grubuna göre anlamlı dü-zeyde yüksek olduğunu göstermişlerdir ancak logistik regresyon analizi sonucu TNF-α düzeyi ile Alopesi areata arasında bir ilişki ortaya konulamamıştır (18). Benzer şekilde Rossi ve ark.…”

Section: Discussionunclassified

ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

Ateş¹

2017

Kocatepe Tıp Dergisi

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Alopesi Areata patogenezinde, değişmiş T hücre aracılı bağışıklığın rol aldığını gösteren çok sayıda çalışma bulunmaktadır. Sitokinlerin ve kemokinlerin Alopesi Areata'nın immun sürecinde önemli rol oynamasından dolayı, Alopesi Areata'ya yatkınlık ile TNF-α-308G/A polimorfizmi arasındaki olası bağlantının Türk populasyonunda araştırılması amacıyla bu çalışma gerçekleştirildi. GEREÇ VEYÖNTEM: Sunulan vaka kontrol çalışmasına 107 Alopesi Areata hastası ve 113 sağlıklı kontrol bireyi dahil edildi. TNF-α-308G/A polimorfizminin genotiplendirmesi Polimeraz Zincir Reaksiyonu (PZR) ve Restriksiyon Enzim Analizi (REA) yöntemleri ile gerçekleştirildi. BULGULAR: Hasta ve kontrol gruplarında TNF-α-308 G/A genotiplerinin ve allel frekanslarının dağılımı arasında anlamlı bir bağlantı bulunamadı (p=0.673 ve p=0.177, sırasıyla). Benzer şekilde, TNF-α-308 G/A polimorfizmi ile Alopesi Areata'nın klinik bulguları arasında fark tespit edilemedi. SONUÇ: Bu çalışma, TNF-α-308 G/A polimorfizminin Türk populasyonunda Alopesi Areata gelişiminde önemli bir rol oynamadığını göstermektedir.

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Identification of blood microRNA alterations in patients with severe active alopecia areata

Sheng

et al. 2019

J of Cellular Biochemistry

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Background Alopecia areata (AA) is a common inflammatory disease characterized by cellular infiltration of T cells targeting the anagen‐stage hair follicle. Lack of efficacious treatment for AA may be due to little knowledge about its exact cellular mechanism. Studies have demonstrated that microRNAs (miRNAs) play an important role in the regulation of inflammatory skin diseases such as atopic dermatitis and psoriasis. However, little is known about the role of miRNAs in AA. Objective The present study aimed to explore the blood miRNAs alterations in patients with severe active AA. Methods We constructed a bipartite miRNA‐messenger RNA (mRNA) regulatory network by the validated miRNA‐mRNA relationships. Subsequently, the miRNA‐miRNA synergistic network was formed in consideration of the Gene Ontology function enrichment of coregulated target genes. Lastly, the functional network was identified by the ingenuity pathway analysis. Results By using an Agilent microarray that covers 2549 human miRNAs, we identified 36 significantly differentially expressed miRNAs in severe active AA patients. miRNA target gene prediction and functional annotation analysis showed significant enrichment in several pathways including the ribosome, cancer, cell cycle, insulin signaling, transforming growth factor‐βsignaling, and p53 signaling pathways. Analysis of the three kinds of network showed that miR‐185‐5p, miR‐125b‐5p, and miR‐186‐5p might play important and synergistic roles in the active phase of AA. According to the receiver operating characteristic curve analysis, several miRNAs were selected for the quantitative real‐time polymerase chain reaction validation. Among the miRNAs, miR‐210 and miR‐1246 had high prediction with high accuracy. Conclusion Blood dysregulated miRNAs are potentially associated with the severe active AA. These miRNAs could function synergistically and might be promising targets for the development of novel treatments for AA in the future.

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Serum cytokine and chemokine profiles in patients with alopecia areata

Abstract: This study suggests that CCL17 and CCL27 may have an aggravating effect, whereas IL-23 may have a protective effect for the development of AA. Additionally, serum CCL27 levels may be useful as marker of disease severity.

Cited by 30 publications

References 26 publications

Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity

Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity

ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

Identification of blood microRNA alterations in patients with severe active alopecia areata

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