Serum cytokine levels in Kleine–Levin syndrome

Kornum, Birgitte Rahbek; Rico, Tom; Li, Gang; Huang, Yu‐Shu; Arnulf, Isabelle; Jennum, Poul; Mignot, Emmanuel

doi:10.1016/j.sleep.2015.02.540

Cited by 19 publications

(10 citation statements)

References 26 publications

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“…A co-ordinated international effort to consistently diagnose, investigate, and manage KLS is progressing our understanding of this disease. Genetic studies examining the many polymorphisms affecting immune responsiveness [ 73 ] would be of interest. Ultimately, the possibility of an autoimmune aetiology will only be addressed by a co-ordinated multi-centre randomised interventional study using immunosuppressive drugs, which should now be possible.…”

Section: Discussionmentioning

confidence: 99%

“…A number of authors have suggested viral infection as a trigger for KLS [ 21 , 69 , 70 , 72 , 73 ]. In 168 primary and 18 secondary cases of sporadic KLS reviewed by Arnulf [ 3 ], preceding infection was documented in 38.1% of patients who subsequently developed KLS.…”

Section: Introductionmentioning

confidence: 99%

“…However, CSF examination was normal in 70 of the cases reviewed by Arnulf [ 3 ], and plasma C-reactive protein concentrations have been reported as normal in KLS [ 4 ]. A comprehensive study of serum inflammatory cytokines did not reveal any changes during KLS episodes compared to between episodes [ 73 ]. Thus, primary CNS infection is unlikely as a cause of KLS.…”

Section: Introductionmentioning

confidence: 99%

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Kleine-Levin syndrome: clues to aetiology

2018

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Kleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence of 1–2 per million population. Clear diagnostic criteria are now defined, but effective treatment remains elusive. The significant body of published literature allows consideration of possible aetiological mechanisms, an understanding of which could guide the development of therapeutic strategies. Functional imaging studies have been inconclusive; although diencephalic abnormalities are a common finding, no consistent pattern has emerged, and these studies have not revealed the mechanism(s) underlying the development of the abnormalities detected. An autoimmune aetiology is consistent with the available data. In this review, we argue that, in order to further our understanding of KLS, there needs to be a co-ordinated international effort to standardise approaches to functional imaging studies, genetic analyses that specifically address the possibility of an autoimmune aetiology, and clinical trials of immunosuppressive therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kleine-Levin syndrome: clues to aetiology

2018

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“…In addition, high rates of birth difficulties are commonly reported among patients (76,79). Results in HLA genotyping are inconclusive in KLS (76,77,80), inflammation markers are not present (76) and no systemic immune reaction has been observed during episodes (81). Although CSF hypocretin-1 is usually within the normal range, lower levels have been described during episodes and, in a recent study (82), were related to abnormal autonomic function (lower heart rate and diurnal blood pressure).…”

Section: Pathophysiologymentioning

confidence: 98%

Clinical update on central hypersomnias

Pérez-Carbonell

Leschziner

2018

J. Thorac. Dis.

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The central hypersomnias encompass a range of conditions causing persisting or intermittent excessive daytime sleepiness (EDS). These conditions therefore present not infrequently in general clinical sleep practice, and remain in the differential for patients presenting with sleepiness. Our understanding of the pathophysiology, diagnosis and management of these conditions has progressed significantly over recent years, and in this article we review this group of disorders, focussing in particular on recent changes in classification and diagnosis, pathophysiological advances, and novel treatment options.

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“…Uma associação com o antígeno leucocitário humano (HLA) DQB1*02 foi encontrada em um estudo publicado em 2002, em que os autores coletaram registros clínicos, polissonográficos, LCR, tomografia computadorizada e ressonância magnética e analisaram os polimorfismos genéticos de HLA-DQB1, triptofano hidroxilase e COMT em 30 pacientes não relacionados com SKL e suas famílias. Apenas a frequência alélica do HLA-DQB1*02 esteve significativamente aumentada em pacientes com SKL, mas este achado, no entanto, não foi replicado em estudos prospectivos, e nenhuma outra associação HLA-DRB1 /-DQB1 foi encontrada(DAUVILLIERS et al, 2002;AFOLABI-BROWN; MASON, 2018;GROOS;DODET, 2018;ALSHAREEF; BAHAMMAM, 2018) Kornum et al, (2015). realizaram um estudo para demonstrar que a SKL poderia ser causada por uma resposta imune anormal em indivíduos geneticamente suscetíveis, porém os níveis séricos de citocinas se mostraram normais, sugerindo que os episódios da SKL não são acompanhados por uma reação imune sistêmica anormal.…”

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Abordagens contemporâneas nas ciências da saúde

2021

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Esta publicação traz alguns estudos apresentados em quatro capítulos, I. Viabilidade econômica do cultivo de tambaqui (Colossoma macropomum) em tanques escavados abastecidos com e sem bombeamento; II. Viabilidade econômica do cultivo de tambaqui (Colossoma macropomum) em relação a outras atividades agropecuárias no estado de Rondônia; III. Caracterização limnológica do ciclo de cultivo do pirarucu (Arapaima gigas) em viveiro escavado na Amazônia Ocidental; e Inovações nos aspectos produtivos do pirarucu (Arapaima gigas) cultivado na Amazônia Ocidental. Este livro cumpre os objetivos de analisar a viabilidade econômica da implantação e manutenção do cultivo de tambaqui (Colossoma macropomum) em diferentes modelos de produção. E também, demonstrar a viabilidade econômica da piscicultura na criação de tambaqui, em comparação a outras atividades agropecuárias, usando a taxa interna de retorno (TIR), Payback e rentabilidade para identificar qual atividade é mais viável, apresentando uma análise das vantagens e desvantagens da piscicultura. Outro objetivo alcançado foi caracterizar a qualidade da água em um ciclo de cultivo do pirarucu (Arapaima gigas). Bem como relatar pesquisas sobre as inovações na criação de pirarucu na Amazônia.

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Serum cytokine levels in Kleine–Levin syndrome

Cited by 19 publications

References 26 publications

Kleine-Levin syndrome: clues to aetiology

Kleine-Levin syndrome: clues to aetiology

Clinical update on central hypersomnias

Abordagens contemporâneas nas ciências da saúde

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