Serum cytokine levels in patients with hidradenitis suppurativa vary with race

McKay, Cather; Kuraitis, Drew; Murina, Andrea

doi:10.1016/j.jaad.2020.08.084

Cited by 7 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cytokines TNF-α, IL-22, IL-23, IL-17, IL-27 and IL-10, in subgroup analysis by race, showed higher concentrations in African-American patients [92]. A greater delay in diagnosis is observed in non-white patients.…”

Section: Hidradenitis Suppurativa and Ethnicitymentioning

confidence: 86%

Qualitative Systematic Review on the Bio-Psycho-Socioeconomic Impact of Hidradenitis Suppurativa/Acne Inversa

Augusto,

Monica,

Giulia

et al. 2024

J Surgery

View full text Add to dashboard Cite

Hidradenitis Suppurativa or Acne Inversa (HS) is a chronic, inflammatory, recurrent integumentary disease, with periods of exacerbation, related to metabolic comorbidities, affecting the well-being, quality of life and mental health of patients, in addition to negatively influencing oral health and women’s health levels as well. It often presents little responsiveness to conventional dermatological treatments. With the aim of estimating the biopsychosocial and economic impact on patients’ lives, a qualitative systematic review was planned. The results were similar to clinical practice and also with several qualitative reviews, i.e. low efficiency. It was observed few studies of good quality, low number randomized clinical trials, and quantitative systematic review, as well. Thus, (HS) has not yet been mapped into the Evidence-Based paradigm and justifies the low assertiveness of therapeutic modalities conventionally instituted to date, as most of them are still structured empirically. Under this circumstance, and due experience and achieviments with these patients at the Instituto da Pele/Departamento de Dermatologia da Escola Paulista de Medicina da Universidade Federal de São Paulo/UNIFESP/Brazil (Monson 2019) [1], was decided to expand spectrum the research, and to add Oral and Systemic Health and Women’s Health, simultaneously to the conventionally studied biopsycho-social parameters. The results were not surprising and revealed the importance of expanding scientific research on HS. As implications for practice, we sought to qualitatively map knowledge to help organize a comprehensive minimum protocol for HS care beyond the conventionally adopted parameters, and include ways of measuring the quality levels of oral health and women’s health with aimed at the quality of life of these patients. Thus, a more realistic and assertive management could be given to the target population, as well as the adoption of complementary therapeutic modalities (according to WHO parameters), and applied in a co-intervention regime, to control these new sets of comorbidities that have been considered by the present study with the objective of increasing the levels of efficacy, effectiveness and safety by Good Clinical Practices. Even though we still do not have the methodological conditions to establish Guidelines for HS, we at least strive to make care for these patients increasingly humanized and inclusive

show abstract

Section: Hidradenitis Suppurativa and Ethnicitymentioning

confidence: 86%

Qualitative Systematic Review on the Bio-Psycho-Socioeconomic Impact of Hidradenitis Suppurativa/Acne Inversa

Augusto,

Monica,

Giulia

et al. 2024

J Surgery

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the interplay among genetics, lifestyle, hormonal status, microbiome, and innate and adaptive immune system remains unclear. Furthermore, multicenter and large-scale (racially diverse [ 265 ]) OMICs studies are needed to identify novel actors (and possible new therapeutic targets) in HS etiopathogenesis and to improve tailored therapy [ 266 ]. In the near future, artificial intelligence (AI) might play a role in HS, firstly in clinical trials, and then becoming useful (for clinicians and patients) in daily clinical practice [ 267 , 268 ].…”

Section: Discussionmentioning

confidence: 99%

Insights into the Pathogenesis of HS and Therapeutical Approaches

et al. 2021

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is a debilitating, chronic, (auto)inflammatory disease primarily affecting apocrine gland-rich areas of the body. Although pathogenic mechanisms responsible for HS have not yet been fully elucidated, it is a multifactorial process whose main target is the terminal follicle. The role of the inflammatory process (and consequently of cytokine milieu) and of several other factors (genetics, lifestyle, hormonal status, microbiome, innate and adaptive immune systems) involved in HS pathogenesis has been investigated (and often defined) over the years with a view to transferring research results from bench to bedside and describing a unique and universally accepted pathogenetic model. This review will update readers on recent advances in our understanding of HS pathogenesis and novel (potential) medical therapies for patients with moderate-to-severe HS.

show abstract

“…Fairly recently, variation with race in serum cytokine levels was observed by McKay and colleagues. The researchers found that six cytokines (out of 25 analyzed) were lower in African American HS patients compared to other races [ 37 ].…”

Section: Hs and Race/ethnicitymentioning

confidence: 99%

Hidradenitis Suppurativa: The Influence of Gender, the Importance of Trigger Factors and the Implications for Patient Habits

et al. 2022

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is a debilitating, chronic, inflammatory skin disease primarily affecting apocrine gland-rich areas of the body. On the one hand, the presence of triggering factors—some identified, others only hypothesized—may initiate or perpetuate the pathogenic process of HS. In addition to cigarette smoking and diet, other trigger factors, including choice of clothing, are frequently observed in clinical practice. On the other hand, the presence of disease may influence habits of HS patients. Indeed, high incidences of sexual and sleep impairment have been reported in these patients. Consequently, alcohol and substance abuse may be a coping strategy for the emotional and psychological disease burden. Furthermore, a greater awareness of gender differences in HS may be important for dermatologists in their own clinical practice (i.e., pregnancy and breastfeeding). Consequently, in this loop interaction, comprehensive knowledge of all factors involved is crucial for the management of HS patients. Thus, the objective of this review is to (i) discuss the influence of gender on HS, (ii) summarize the most frequent triggering factors of HS and (iii) analyze the impact of HS on patient habits.

show abstract

Serum cytokine levels in patients with hidradenitis suppurativa vary with race

Cited by 7 publications

References 5 publications

Qualitative Systematic Review on the Bio-Psycho-Socioeconomic Impact of Hidradenitis Suppurativa/Acne Inversa

Qualitative Systematic Review on the Bio-Psycho-Socioeconomic Impact of Hidradenitis Suppurativa/Acne Inversa

Insights into the Pathogenesis of HS and Therapeutical Approaches

Hidradenitis Suppurativa: The Influence of Gender, the Importance of Trigger Factors and the Implications for Patient Habits

Contact Info

Product

Resources

About