Serum cytokine levels related to exposure to volatile organic compounds and PM&lt;sub&gt;2.5&lt;/sub&gt; in dwellings and workplaces in French farmers &amp;ndash;&amp;nbsp;a mechanism to explain nonsmoking COPD

Audi, Christelle; Baïz, Nour; Maesano, Cara Nichole; Ramousse, Ollivier; Reboulleau, Damien; Magnan, A.; Caillaud, D.; Annesi‐Maesano, Isabella

doi:10.2147/copd.s117866

Cited by 35 publications

(33 citation statements)

References 42 publications

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“… 17 In addition, an epidemiological study showed that chronic exposure to high levels of VOCs was significantly associated with reduced serum IL-13 concentrations. 18 …”

Section: Discussionmentioning

confidence: 99%

Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children

Yon

et al. 2018

Allergy Asthma Immunol Res

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Epidemiological studies have shown that exposure to tobacco smoke causing irritation and inflammation in the airways tends to reduce serum periostin concentrations in adults. We now investigate prospective cross-sectional study on 135 Korean students aged 7 years in the first grade who were participating in the Seongnam Atopy Project for Children's Happiness 2016 (SAP2016) cohort. To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children. Our findings suggested the need for caution in using the serum periostin level as a marker for allergic diseases, since exposure to volatile organic compounds and formaldehyde may confound the interpretation of these results.

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“… 17 In addition, an epidemiological study showed that chronic exposure to high levels of VOCs was significantly associated with reduced serum IL-13 concentrations. 18 …”

Section: Discussionmentioning

confidence: 99%

Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children

Yon

et al. 2018

Allergy Asthma Immunol Res

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“…The mechanisms by which VOCs may act on respiratory health are based on irritation [25] or on the alteration of cytokine levels that may be involved in the inception of respiratory diseases, such as COPD in farmers due to their exposure to these chemicals [26].…”

Section: Discussionmentioning

confidence: 99%

“…In the adult population, exposure to aromatic compounds has been found to be significantly associated with physician-diagnosed asthma (adjusted OR = 1.63, 95% CI: 1.17–2.27) [9]. In addition, total VOCs has been found associated with an increasing risk of shortness of breath in adults [26] and asthma in children [16].…”

Section: Discussionmentioning

confidence: 99%

Indoor exposure to particulate matter and volatile organic compounds in dwellings and workplaces and respiratory health in French farmers

Maesano

Caillaud

Youssouf

et al. 2019

Multidiscip Respir Med

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IntroductionFew investigations have related objective assessments of indoor air pollutants to respiratory health in farmers, in spite of the many rural environmental hazards to which they are exposed. Chemical air pollution has been particularly neglected.ObjectiveWe investigated the relationships of indoor exposure to particulate matter (PM) and volatile organic compounds (VOCs) to respiratory health in farmers.MethodsNineteen VOCs (5 families) and PM (from ultrafine to total suspended particles (TSP)) were objectively assessed in dwellings and workplaces in 109 French farmers during a week. To take into account multiple exposures, scores of exposure were computed for total VOCs and VOCs families. Individuals filled a standardized questionnaire and underwent spirometry with bronchodilation test.ResultsOn average, VOCs concentrations were higher in dwellings than in workplaces. The reverse was observed for PM. When considering the mean concentrations of air pollutants for the whole farm (dwellings + workplaces), asthma (9.3%) was positively associated with elevated exposure to benzene (adjusted odds-ratio (ORa) = 6.64, 95%CI: 1.56–28.27), trichloroethylene (4.80, 1.00–23.30) and halogenated hydrocarbons score (2.9, 95% 1.3–6.8). Early airway obstruction (FEF25–75 < 80%, with normal FEV1 and FVC and FEV/FVC ≥ 70%) (29.8%) was related to elevated exposure to 2-butoxyetylacetate (11.49, 1.55–85.37) and glycol ethers score (2.0; 1.0–4.1) in the whole farm and to PM2.5 (ORa = 5.26, 95% CI: 1.09–25.28) in the granary/stable. The risk of Chronic Obstructive Pulmonary Diseases (FEV/FVC < 70%) (COPD) (4.26%) was found to be larger with elevated exposure to aldehydes (OR = 3.95, 1.09–14.26).ConclusionIndoor chemical air pollution is detrimental to farmers’ respiratory health. More epidemiological investigations with detailed exposure assessments and clinical measures of respiratory effects are needed in rural settings to corroborate these findings.

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“…Particulate matter (PM), as an important indicator of air pollution, has aroused widespread concern. As reported, it has correlated with many respiratory diseases [1][2][3]. The animal farmers, they are at a higher prevalence of chronic bronchitis and chronic obstructive pulmonary disease (COPD) than the no-farming people [4][5][6].…”

Section: Introductionmentioning

confidence: 95%

The Distribution Characteristic of Microbial Aerosols Inside a Nursery Pig House and the Respiratory Tract of Piglets

Tang

Huang

Liu

et al. 2020

Preprint

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Abstract Background: The particulate matter (PM) is a carrier of many substances. Microorganisms are vital constituents contained in PM and the kinds and concentration are closely connected to human health and animal production. This study was aimed to investigate the distribution characteristics of microbial aerosols inside the pig house and as well as in the respiratory tract of pigs. The environment inside a nursery pig house was monitored in winter, including temperature, relative humidity, TSP, PM10, PM2.5, NH3, CO2, CO and NO. The concentrations of airborne culturable bacteria, fungi and Escherichia coli were detected. Then 16 S rRNA sequencing technology was applied to identify bacteria contained in different sized PM and the bacteria in the respiratory tract of piglets.Results: The results showed that the concentration of airborne culturable bacteria inside the pig house was significantly higher than that outside. The concentration of airborne culturable bacteria was reduced with the decrease of the size of PM; the concentration of airborne culturable fungi was mostly distributed in the size of 2.1-3.3 μm and 1.1-2.1 μm PM; most airborne culturable Escherichia coli were distributed in the size of >7.0 μm and 2.1-3.3 μm. Besides, these three types of microbial aerosols did not exhibit significant change during different time points. The 16 S rRNA results showed that the bacteria contained in PM had high similarity with that in the respiratory tract of pigs. The bacteria assemblage in the size of 1.1-3.3 μm PM had high similarity with that in the lower respiratory tract (bronchus and lung) of pigs. In addition, four potential pathogenic bacteria genera (Escherichia-Shigella, Streptococcus, Acinetobacter, Pseudomonas) were identified in the PM samples and the respiratory tract.Conclusions: These results will provide a significant scientific basis in exploring the potential risk of aerosol from animal houses for human and animal health.

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Serum cytokine levels related to exposure to volatile organic compounds and PM<sub>2.5</sub> in dwellings and workplaces in French farmers – a mechanism to explain nonsmoking COPD

Cited by 35 publications

References 42 publications

Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children

Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children

Indoor exposure to particulate matter and volatile organic compounds in dwellings and workplaces and respiratory health in French farmers

The Distribution Characteristic of Microbial Aerosols Inside a Nursery Pig House and the Respiratory Tract of Piglets

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