Serum cytokine profiles in Behçet's disease: Is there a role for IL-15 in pathogenesis?

Curnow, S. John; Pryce, K.; Modi, Neil; Knight, B.; Graham, Elizabeth; Stewart, James E.; Fortune, Farida; Stanford, Miles; Murray, Philip I.; Wallace, Graham R.

doi:10.1016/j.imlet.2008.07.009

Cited by 40 publications

(28 citation statements)

References 30 publications

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“…Thus, ulcer formation in RAU may result not only from Tc cell but also from NK cell cytotoxity. The importance of IL-15 in RAU pathogenesis is additionally supported by the recent findings showing an increased IL-15 serum level in RAU patients (Curnow et al 2008).…”

Section: Discussionmentioning

confidence: 62%

Expression of Th1/Th2/Th3/Th17-Related Genes in Recurrent Aphthous Ulcers

Lewkowicz

Kur

Kurnatowska

et al. 2011

Arch. Immunol. Ther. Exp.

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The pathogenesis of recurrent aphthous ulceration (RAU) is unknown, although an abnormal immune reaction appears to be involved. RAU may result from oral epithelium damage caused by T cell-mediated immune response. To improve understanding of the role of T cells in RAU, the present study analyzed. the expression of T cell-related genes in oral ulcers from patients with RAU, as well as in healthy non-keratinized oral mucosa from aphthae-free volunteers. Biopsies from RAU patients and healthy individuals were analyzed using Human Th1-Th2-Th3 RT(2) Profiler PCR Array and qRT-PCR that allowed to quantify the transcript levels of 86 genes related to T cell activation. We found that cells present in aphthous ulcers express a characteristic Th1-like gene profile. The majority of genes up-regulated in aphthous lesions such as IFN-γ, TNF, IL-15, IRF1, STAT-1 and STAT-4 were Th1-associated. Th2-realated genes were not overexpressed in RAU tissues, with the exception for CCR3. Th3- and Th17-related gene expression patterns were not demonstrated in RAU. These findings clearly reveal that aphthous ulcer formation is predominantly dependent on the activation of the Th1-type immune response.

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Section: Discussionmentioning

confidence: 62%

Expression of Th1/Th2/Th3/Th17-Related Genes in Recurrent Aphthous Ulcers

Lewkowicz

Kur

Kurnatowska

et al. 2011

Arch. Immunol. Ther. Exp.

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“…Moreover, four other studies found no correlation between BD activity and the serum level of TNF-a. 22,25,39,40 It may be that serum levels of this cytokine do not fully reflect local tissue concentrations. Zouboulis et al 40 showed increased TNF-a expressions in lesional skin biopsies of BD patients compared with healthy skin biopsies of BD patients, but serum levels of TNF-a did not correlate with enhanced tissue deposition.…”

Section: Discussionmentioning

confidence: 99%

Expression of a soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) correlates with clinical disease activity in intestinal Behcetʼs disease

Jung

Kim

Yoon

et al. 2011

Inflammatory Bowel Diseases

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“…It was previously shown that cytokines, such as Interleukin 1 (IL-1), Interleukin 6 (IL-6), Interleukin 12 (IL-12), Interleukin 18 (IL-18), Tumor Necrosis Factor alpha (TNF-α), and Interferon gamma (IFN-γ); chemokines, such as IL-8; cytokine receptors, such as soluble Interleukin-2 receptor (sIL2R); and chemokine antagonist and receptors were increased in peripheral blood and tissue samples of BD patients (13)(14)(15). However, even the largest comprehensive study could only investigate 17 inflammatory molecules at the same time with a microbead system in BD (16). Our study is therefore the most comprehensive study in this category.…”

Section: Discussionmentioning

confidence: 99%

Immune and inflammatory gene expressions are different in Behçet’s disease compared to those in Familial Mediterranean Fever

et al. 2017

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Objective: The immune classification of Behçet's disease (BD) is still controversial. In this study, we aimed to compare the immune/ inflammatory gene expressions in BD with those in familial Mediterranean fever (FMF), an autoinflammatory disorder with innate immune activation.Material and Methods: CD4+ T cells and CD14+ monocytes were isolated from the peripheral blood mononuclear cells of Behçet's disease patients (n=10), FMF (n=6) patients, and healthy controls (n=4) with microbeads, and then, the mRNA was isolated. The expressions of 440 genes associated with immune and inflammatory responses were studied with a focused DNA microarray using a chemiluminescent tagging system. Changes above 1.5-fold and below 0.8-fold were accepted to be significant. Results:In BD patients, in the CD4+ T-lymphocyte subset, interleukin 18 receptor accessory protein (1.7-fold), IL-7 receptor (1.9-fold), and prokineticin 2 (2.5-fold) were all increased compared to those in FMF patients, whereas chemokine (C-X3-C motif ) receptor-1 (CX3CR1) (0.7-fold) and endothelial cell growth factor-1 (0.6-fold) were decreased. In the CD14+ monocyte population, the V-fos FBJ murine osteosarcoma viral oncogene homolog (1.5-fold), Interleukin-8 (IL-8) (2.1-fold), and Tumor Necrosis Factor alpha (TNF-α) (1.8-fold) were all increased, whereas the chemokine (C-C motif ) ligand 5 (CCL5) (0.6-fold), C-C chemokine receptor type 7 (0.6-fold), and CX3CR1 (0.7-fold) were decreased, again when compared to those in FMF. Compared to healthy controls in the CD4+ T-lymphocyte population, in both BD and FMF patients, pro-platelet basic protein and CD27 had elevated expression. In BD and FMF patients, 24 and 19 genes, respectively, were downregulated, with 15 overlapping genes between both disorders. In the CD14+ monocytes population, chemokine (C-C motif ) receptor-1 (CCR1) was upregulated both in BD and FMF patients compared to that in the controls, whereas CCL5 was downregulated. Conclusion:Immune and inflammatory gene expressions seem to be variable in both the innate (CD14+) and adaptive (CD4+) immune responses in BD and FMF patients compared to those in controls, suggesting differences in immune regulation between the two disorders.

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Serum cytokine profiles in Behçet's disease: Is there a role for IL-15 in pathogenesis?

Cited by 40 publications

References 30 publications

Expression of Th1/Th2/Th3/Th17-Related Genes in Recurrent Aphthous Ulcers

Expression of Th1/Th2/Th3/Th17-Related Genes in Recurrent Aphthous Ulcers

Expression of a soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) correlates with clinical disease activity in intestinal Behcetʼs disease

Immune and inflammatory gene expressions are different in Behçet’s disease compared to those in Familial Mediterranean Fever

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