Serum cytokines and clinical features in patients with fever and thrombocytopenia syndrome

Chen, Huanzhu; Lin, Chun Long; Fan, Zhiqiang; Yu, Wenjun; Cao, Manxiong; Ke, Changwen; Jiao, Xiaoyang

doi:10.1016/j.cca.2019.02.034

Cited by 13 publications

(13 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other than diabetes, chills, body temperature > 37.5°C, and abnormal findings on initial chest X-ray such as haziness or consolidation were risk factors for proceeding to severe-stage disease. Chills and fever are responses to released inflammatory mediators such as cytokines and chemokines [14,15]. These inflammatory mediators cause tissue damage and organ dysfunction by stimulating toxic oxygen derivatives [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for disease progression in COVID-19 patients

Lee

Park²,

Kim³

et al. 2020

BMC Infect Dis

137

114

View full text Add to dashboard Cite

Background: Coronavirus disease (COVID-19) is rapidly spreading worldwide. Although 10-20% of patients with COVID-19 have severe symptoms, little is known about the risk factors related to the aggravation of COVID-19 symptoms from asymptomatic or mild to severe disease states. Methods: This retrospective study included 211 patients who were asymptomatic or with mild presentations of COVID-19. We evaluated the differences in demographic and clinical data between the cured (discharged to home) and transferred (aggravated to severe-stage COVID-19) groups. Results: A multivariate logistic analysis showed that body temperature, chills, initial chest X-ray findings, and the presence of diabetes were significantly associated with predicting the progression to severe stage of COVID-19 (p < 0.05). The odds ratio of transfer in patients with COVID-19 increased by 12.7-fold for abnormal findings such as haziness or consolidation in initial chest X-ray, 6.32-fold for initial symptom of chills, and 64.1-fold for diabetes. Conclusions: Even if patients are asymptomatic or have mild symptoms, clinicians should closely observe patients with COVID-19 presenting with chills, body temperature > 37.5°C, findings of pneumonia in chest X-ray, or diabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors for disease progression in COVID-19 patients

Lee

Park²,

Kim³

et al. 2020

BMC Infect Dis

137

114

View full text Add to dashboard Cite

show abstract

“…Fever, a respiratory manifestation, is the most commonly reported symptom in patients infected with SARS-CoV-2 [ 15 , 16 ]. Accordingly, fever may be a clinical sign of poor prognosis in patients and response to the release of inflammatory mediators such as cytokines and chemokines [ 17 , 18 ]. These inflammatory mediators cause tissue damage and organ dysfunction by stimulating toxic oxygen derivatives suggesting that the NCT of SARS-CoV-2 RNA may be prolonged in fever patients [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of hospitalized mild/moderate COVID-19 patients with a prolonged negative conversion time of SARS-CoV-2 nucleic acid detection

Yang

Xiong

et al. 2021

BMC Infect Dis

View full text Add to dashboard Cite

Background The impact of COVID-19 has been devastating on a global scale. The negative conversion time (NCT) of SARS-CoV-2 RNA is closely related to clinical manifestation and disease progression in COVID-19 patients. Our study aimed to predict factors associated with prolonged NCT of SARS-CoV-2 RNA in mild/moderate COVID-19 patients. Methods The clinical features, laboratory data and treatment outcomes of COVID-19 patients were retrospectively analyzed. Then univariate and multivariate analysis were used to screen out risk factors of influencing prolonged NCT of SARS-CoV-2 RNA. Results Thirty-two hospitalized mild/moderate COVID-19 patients were enrolled. The general clinical symptoms were cough (78.1%), fever (75%), diarrhea (68.8%), expectoration (56.3%), and nausea (37.5%). More than 40% of the patients had decreased erythrocyte, hemoglobin and leucocyte and 93.8% patients were detected in abnormalities of chest CT. The median NCT of SARS-CoV-2 RNA was 19.5 days (IQR: 14.25–25). Univariate analysis found fever, nausea, diarrhea and abnormalities in chest CTs were positively associated with prolonged NCT of viral RNA (P< 0.05). The multivariate Cox proportional hazard model revealed that fever [Exp (B), 0.284; 95% CI, 0.114–0.707; P<0.05] and nausea [Exp (B), 0.257; 95%CI, 0.096–0.689; P<0.05] were two significant independent factors. Conclusions Fever and nausea were two significant independent factors in prolonged NCT of viral RNA in mild/moderate COVID-19 patients, which provided a useful references for disease progression and treatment of COVID-19.

show abstract

“…Abnormal lymphocyte and abnormal platelets increased the risk of progression to the severity stages of COVID-19. Lymphocytes are important to immunological response, such as cytokines and chemokines [16,17]. Other studies mentioned that patients with abnormal lymphocyte and abnormal platelets were vulnerable to immune system, which could deteriorate general condition and worsen COVID-19 symptoms [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors on the Progression to Clinical Outcomes of COVID-19 Patients in South Korea: Using National Data

Kim

Nam

Kim

2020

IJERPH

View full text Add to dashboard Cite

10–20% of COVID (Corona Virus Disease)-19 cases proceed to a severe stage, and age and the presence of comorbidity increased the risk of death from COVID-19. The identification of risk factors on progression to the severity stages is essential in providing more efficient and suitable management to COVID-19 patients. However, there is insufficient study on risk factors for severity stages of COVID-19 patients. In this study, 2959 confirmed COVID-19 patients were analyzed while using national data, COVID-19 patients Clinical Epidemiological Information provided from the Korea Disease Control and Prevention Agency. The epidemiological variable, hospital room, periods from confirmation to release, initial symptom and vital signs, underlying comorbidities, and initial blood variables were used to verify the relation with progression to severity stages of COVID-19 and severe COVID-19. The chi-square test, welch test, multiple regression and logistic regression analysis were performed. The ICU (Intensive Care Unit) admission rate of patients having characteristics, such as older age, male, abnormal BMI (Body Mass Index), high heart rate, high body temperature, fever, cough, sputum, sore throat, rhinorrhea, fatigue, dyspnea, change of consciousness, diabetes mellitus, hypertension, chronic artery disease, chronic kidney disease, cancer, dementia, abnormal hemoglobin, abnormal hematocrit, abnormal lymphocyte, abnormal platelets, and abnormal white blood cell were high. The risk factors for severe COVID-19 were older age, shorter hospitalization, abnormal lymphocyte, abnormal platelets, dyspnea, change of consciousness, and dementia. Whereas, significant predictors for progression to severity stages of COVID-19 were older age, longer period from confirmation to release, higher BMI, higher body temperature, abnormal lymphocyte, abnormal platelets, fever, no sore throat, dyspnea, no headache, COPD (Chronic Obstructive Pulmonary Disease), and dementia. Therefore, classifying patients with a high risk of severe stage of COVID-19 and managing patients by considering the risk factors could be helpful in the efficient management of COVID-19 patients.

show abstract

Serum cytokines and clinical features in patients with fever and thrombocytopenia syndrome

Cited by 13 publications

References 53 publications

Risk factors for disease progression in COVID-19 patients

Risk factors for disease progression in COVID-19 patients

Clinical characteristics of hospitalized mild/moderate COVID-19 patients with a prolonged negative conversion time of SARS-CoV-2 nucleic acid detection

Risk Factors on the Progression to Clinical Outcomes of COVID-19 Patients in South Korea: Using National Data

Contact Info

Product

Resources

About