Serum cytokines and increased total serum IgE in alcoholics

González‐Quintela, Arturo; Vidal, Carmen; Lojo, S.; Pérez, Luis‐Fernando; Otero-Antón, Esteban; Gudé, Francisco; Barrio, E.

doi:10.1016/s1081-1206(10)63514-4

Cited by 73 publications

(94 citation statements)

References 37 publications

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“…It was initially suggested that advanced liver injury is the cause of increased IgE levels as also occurs in the other immunoglobulins. However, it has been recently reported that serum IgE is only increased in patients with alcoholic cirrhosis when compared with patients suffering from liver cirrhosis produced by other factors (González-Quintela et al, 1999).…”

Section: Ethanol and Humoral Immunitymentioning

confidence: 96%

Influence of alcohol consumption on immunological status: a review

et al. 2002

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The aim of this review is to present and discuss the effect of different levels of alcohol consumption on the immune system. Not only the amount consumed but also the type of alcoholic beverage have to be taken into account in order to determine the consequences on activity, number, distribution, balance, interaction and response of immunocompetent cells. The association between alcohol exposure and the risk of developing an alcohol-related disease is multifactorial. In fact, age, gender, smoking habits, dietary intake and exercise are involved among other factors. The evaluation of the host cellular and humoral immune responses has shown that alcohol may induce some benefits when consumption is moderate. Moreover, those alcoholic beverages that contain antioxidants, such as red wine, could be protectors against immune cell damage. According to the literature consulted, the daily consumption of 10 -12 g and 20 -24 g of alcohol for women and men, respectively, is considered to be a moderate intake; the type of beverage has been established not to be important when defining moderation. Particular attention is often focused on the U-or J-shaped curve which also suggests that light to moderate drinking produces a protective effect. Such an inverse relationship indicates a reduction of risk for both light and moderate consumers and a higher risk not only for hard drinkers, but also for non-consumers.

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Section: Ethanol and Humoral Immunitymentioning

confidence: 96%

Influence of alcohol consumption on immunological status: a review

et al. 2002

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“…Tilg et al demonstrated a higher mean value of serum IL-6 among heavy drinkers compared with controls (7). Gonzalez-Quintela et al reported higher mean values of IL-6 and IL-10 in alcoholic patients compared with healthy volunteers (8). Thus, we were interested in whether alcohol consumption affects serum cytokine levels in a healthy population.…”

Section: Introductionmentioning

confidence: 94%

The relation between serum cytokine levels and common laboratory tests in healthy Japanese males

Tsunoda

Guevarra³

et al. 2003

Environ Health Prev Med

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Objectives: Cytokines are critical regulatory molecules that circulate in blood at measurable levels. However, the epidemiology of serum cytokine levels in healthy populations is still limited, particularly for Japanese populations. The objective of this study was to examine the relation between serum cytokine levels and common laboratory tests in a healthy Japanese population.Methods: We studied serum levels of six cytokines (interleukin-4 (IL-4), IL-5, IL-6, IL-10, interferon-γ (IFN-γ), granulocyte-macrophage colony-stimulating factor (GM-CSF)) in a healthy Japanese population using a sensitive chemiluminescence ELISA (CL-ELISA). We examined the relations between serum cytokine levels and common laboratory tests using multiple regression analysis. We were particularly interested in potential relations between serum cytokine levels and C-reactive protein (CRP) in light of its relation to the risk of cardiovascular events. We also investigated the relation between cytokine levels, alcohol consumption and smoking.Results: After adjusting for the influence of other cytokines and laboratory tests, the serum level of IL-4 was associated with IL-5 and GM-CSF. In addition to IL-4, IL-5 was also associated with IL-10 and IFN-γ. IL-6 was associated with IL-10 and IFN-γ, and IL-10 and IFN-γ were associated with GM-CSF. CRP was significantly negatively associated with serum IL-4 level. IL-6 was weakly correlated with alcohol consumption level in this population. IL-5 among smokers tended to be lower than that among nonsmokers.Conclusions: Close relations among serum cytokine levels were observed in a healthy population. It is interesting that the level of IL-4, an anti-inflammatory cytokine, was inversely related to CRP level, suggested to be a marker of inflammation.

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“…In response to cytokines and growth factors, including interferons, epidermal growth factor, IL-5, IL-6, and hepatocyte growth factor, STAT3 can be activated through phosphorylation by Janus kinase and then form homo-or heterodimers that translocate to the cell nucleus where they act as transcription activators (Desrivieres et al, 2006). IL-6 is readily detected in patients with ALD, and its concentration correlates with the extent of the disease (Gonzalez-Quintela et al, 1999). Furthermore, IL-6-deficient mice are more prone to ethanol-induced apoptosis in the liver (Hong et al, 2002b).…”

Section: Rxr␣-associated Alcoholic Liver Disease 449mentioning

confidence: 99%

Hepatocyte Retinoid X Receptor α-Dependent Regulation of Lipid Homeostasis and Inflammatory Cytokine Expression Contributes to Alcohol-Induced Liver Injury

Gyamfi¹,

He²,

French³

et al. 2007

J Pharmacol Exp Ther

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Hepatocyte retinoid X receptor ␣ (RXR␣)-deficient mice are more sensitive to ethanol toxicity than wild-type mice. Because RXR␣-mediated pathways are implicated in lipid homeostasis and the inflammatory response, we hypothesized that a compromise in lipid metabolism and associated production of proinflammatory mediators are responsible for the hepatotoxicity observed in ethanol-treated hepatocyte RXR␣-deficient mice. Wild-type and hepatocyte RXR␣-deficient mice were fed ethanol-containing diets or pair-fed control diets for 6 weeks. After ethanol treatment, serum ALT levels increased significantly (4-fold) in hepatocyte RXR␣-deficient mice, but not in the wild-type mice. Hepatic liver fatty acid binding protein (L-FABP) mRNA and protein levels were reduced due to RXR␣ deficiency. Ethanol induced L-FABP mRNA and protein in wildtype mice and provided protection against nonesterified fatty acid toxicity; however, this effect was absent in the mutant mice. Accordingly, hepatic nonesterified fatty acid level was increased in ethanol-fed mutant mice. Ethanol increased nuclear factor (NF)-B binding activity in hepatocyte RXR␣-deficient mice, but not in wild-type mice. In agreement, hepatic mRNA levels of proinflammatory cytokines and chemokines were increased to a greater extent in the mutant than in wildtype mice. Furthermore, signal transducer and activator of transcription factor (STAT) 3 and associated Bcl-xL induction was observed in ethanol-fed wild-type mice but not in ethanol-fed hepatocyte RXR␣-deficient mice. Taken together, after ethanol treatment, hepatocyte RXR␣ deficiency results in lack of L-FABP induction, increased hepatic free fatty acids, NF-B activation, and proinflammatory cytokines production and a lack of STAT3 activation, which in part may contribute to alcohol-induced liver damage.In the adult liver, the nuclear receptor, retinoid X receptor ␣ (RXR␣), is the most abundant among the three RXR isoforms (␣, ␤, and ␥) (Mangelsdorf et al., 1992).

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Serum cytokines and increased total serum IgE in alcoholics

Cited by 73 publications

References 37 publications

Influence of alcohol consumption on immunological status: a review

Influence of alcohol consumption on immunological status: a review

The relation between serum cytokine levels and common laboratory tests in healthy Japanese males

Hepatocyte Retinoid X Receptor α-Dependent Regulation of Lipid Homeostasis and Inflammatory Cytokine Expression Contributes to Alcohol-Induced Liver Injury

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