Serum D-dimer as an indicator of immediate mortality in patients with in-hospital cardiac arrest

Added value of the DIC score and of D-dimer to predict outcome after successfully resuscitated out-of-hospital cardiac arrest

“…The presence of disseminated intravascular coagulation (DIC), as assessed on an 8-point scale accounting points for prothrombin time, platelet count, fibrinogen and D-dimer levels [5], has been shown to be a predictor for death in various critical conditions [6]. Indeed increased D-dimer levels alone are associated with poor outcome [7,8].…”

Evaluating the analytical performance of four new coagulation assays for the measurement of fibrinogen, D‐dimer and thrombin time

“…Thrombin time is prolonged by: decreased fibrinogen levels; abnormal function of fibrinogen; the presence of direct thrombin inhibitors, such as dabigatran, bivalirudin or argatroban; the presence of unfractionated heparin; the presence of aprotinin; and the presence of fibrinogen/fibrin degradation products and/or increased fibrinolysis (for example, due to thrombolytic therapy) . D‐dimer is a very sensitive marker for the activation of coagulation . In DIC, fibrin degradation products, such as D‐dimer, can be used to confirm or refute a tentative diagnosis, estimate the potential risk for patients with existing DIC, and monitor an initiated therapy .…”

“…[12][13][14][15][16][17] D-dimer is a very sensitive marker for the activation of coagulation. [18][19][20][21][22][23][24] In DIC, fibrin degradation products, such as D-dimer, can be used to confirm or refute a tentative diagnosis, estimate the potential risk for patients with existing DIC, and monitor an initiated therapy. [25][26][27] D-dimer levels are particularly useful to exclude deep vein thrombosis (DVT) and pulmonary embolism (PE), and may be elevated in the presence of other causes of fibrin formation such as trauma, pregnancy complications, malignant disease or vascular abnormalities.…”

Fibrinogen and D‐dimer levels elevate in advanced hepatocellular carcinoma: High pretreatment fibrinogen levels predict poor outcomes

“…Coagulation and fibrinolysis markers have the potential to serve as predictors of disease and disease severity. For instance, D‐dimer levels can be utilized as a predictor of immediate mortality in patients with in‐hospital cardiac arrest . An increasing body of evidence suggests the existence of a relationship between activation of coagulation and tumor angiogenesis, progression, and metastatic spread .…”

“…For instance, D-dimer levels can be utilized as a predictor of immediate mortality in patients with in-hospital cardiac arrest. 10 An increasing body of evidence suggests the existence of a relationship between activation of coagulation and tumor angiogenesis, progression, and metastatic spread. [11][12][13][14] Fibrinogen and D-dimer levels are easily obtainable tests commonly ordered for inpatients.…”