Serum decorin measurement in prediction of the risk for preterm birth

Atalay, Mehmet Aral; Ozmen, Turan; Demir, Bilge Çetinkaya; Kasapoğlu, Işıl; Özkaya, Güven

doi:10.1016/j.tjog.2017.12.004

Cited by 10 publications

(11 citation statements)

References 25 publications

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“…Thus, to clearly differentiate between a predictor of risk for PPROM versus for preterm labor versus for the end result of preterm birth, it was important to investigate early pregnancy serum decorin and biglycan levels prior to the onset of preterm labor later in pregnancy, in order to evaluate whether expression patterns are similar to those seen prior to PPROM. Atalay et al investigated serum decorin concentrations in women at the time of presentation with preterm labor between 24-and 32-week gestation and reported that median serum decorin levels were significantly lower in cases of preterm labor compared with those in controls [40]. In our study, we did not find significant differences in early pregnancy serum concentrations for either decorin or biglycan, suggesting that they do not have a role in predicting preterm labor before labor has commenced.…”

Section: Discussioncontrasting

confidence: 69%

Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth

et al. 2020

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Preterm birth is a leading cause of infant morbidity and mortality. Decorin and biglycan are proteoglycans that play key roles in maintaining the connective tissue matrix and tensile strength of human fetal membranes and have been previously linked to PPROM. Extracellular matrix proteins, such as matrix metalloproteinase 2 (MMP-2), matrix metalloproteinase 9 (MMP-9), TIMP metallopeptidase inhibitor 1 (TIMP-1), TIMP metallopeptidase inhibitor 2 (TIMP-2), and collagen VI (COL-6), have also been linked to PPROM and may have utility in a serum-based screening model for this condition. To define the natural course of serum decorin and biglycan expression throughout the duration of healthy pregnancy, to explore patterns of serum decorin and biglycan expression in serum of asymptomatic women who go on to develop spontaneous preterm labor, and to investigate the potential role for matrix metalloproteinases, their inhibitors, and collagen VI in a serum-based screening model to predict PPROM. Serum decorin level decreases less than 1% per week, and serum biglycan decreases by 2.9% per week over the duration of healthy pregnancy. Serum decorin and biglycan concentrations do not differ in spontaneous preterm labor cases compared with those in controls. Mean concentrations of MMP-2, MMP-9, TIMP-1, TIMP-2, and COL-6 do not differ in PPROM cases compared with those in controls. We have demonstrated that serum decorin and biglycan concentrations remain stable throughout the duration of normal pregnancy and are not early indicators of preterm labor, while common MMPs, TIMPs, and collagen VI are not early indicators of PPROM.

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Section: Discussioncontrasting

confidence: 69%

Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth

et al. 2020

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“…Consistent with this finding, preterm labor patients displayed lower serum DCN levels. While serum DCN levels alone could predict PTB before 37th gestational week among preterm labor patients, a combined measurement with cervical length was required to predict PTB within 7 days and before the 34th gestational week [ 161 ]. PPROM was associated with lower DCN serum levels appearing in the second trimester [ 145 ] and a decline in p-Smad-2 [ 134 ].…”

Section: Role Of Dcn In Pregnancy-associated Disordersmentioning

confidence: 99%

Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases

Halari

Zheng

Lala

2021

IJMS

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Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structural–functional integrity of the placenta and fetal membranes, and their alterations can result in several pregnancy-associated diseases. In this review, we briefly discuss normal placental structure and functions, define and classify SLRPs, and then focus on two SLRPs, decorin (DCN) and biglycan (BGN). We discuss the consequences of deletions/mutations of DCN and BGN. We then summarize DCN and BGN expression in the pregnant uterus, myometrium, decidua, placenta, and fetal membranes. Actions of these SLRPs as ligands are then discussed in the context of multiple binding partners in the extracellular matrix and cell surface (receptors), as well as their alterations in pathological pregnancies, such as preeclampsia, fetal growth restriction, and preterm premature rupture of membranes. Lastly, we raise some unanswered questions as food for thought.

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“…36 Recently, a prospective study by Atalay et al investigated decorin levels in women 24 to 32 weeks gestation who presented to the hospital in labor. 37 In this study, decreased serum levels of decorin were determined in patients with PTL compared to healthy pregnancies. The authors concluded that serum decorin levels had no effect in predicting preterm births before 34 weeks gestation in women with PTL.…”

Section: Discussionmentioning

confidence: 96%

Serum Decorin and Biglycan as Potential Biomarkers to Predict PPROM in Early Gestation

et al. 2020

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Preterm birth is a leading cause of neonatal mortality in the US and globally, with preterm premature rupture of fetal membranes (PPROM) accounting for one third of preterm births. Currently no predictive diagnostics are available to precisely assess risk and potentially reduce the incidence of PPROM. Bigycan and decorin, the main proteoglycans present in human fetal membranes, are involved in the physiological maturation of fetal membranes as well as in the pathophysiology of preterm birth. The serum protein sex hormone-binding globulin (SHBG) has recently been identified as a predictor of spontaneous preterm birth. We hypothesize that the balance between serum decorin and biglycan on one hand and SHBG on the other hand may provide insight into the status of the fetal membranes in early pregnancy, thereby predicting PPROM prior to symptoms. Using chart review, 18 patients with confirmed cases of PPROM were identified from 2013-2016. Second trimester residual serum was retreived from freezer storage for these cases along with 5 matched controls for each case. The biomarkers biglycan, decorin and SHBG were analyzed first separately, then in combination to determine their ability to predict PPROM. The predictive score for the combined model displays an AUC ¼ 0.774. The ROC curve of the predicted score has an optimal threshold of 0.238 and a sensitivity and specificity of 0.72 and 0.84 respectively. This prenatal serum panel is a promising serum screening-based biochemical model to predict PPROM in asymptomatic women.

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Serum decorin measurement in prediction of the risk for preterm birth

Cited by 10 publications

References 25 publications

Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth

Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth

Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases

Serum Decorin and Biglycan as Potential Biomarkers to Predict PPROM in Early Gestation

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