Serum Dehydroepiandrosterone Sulfate and Incident Depression in the Elderly: The Pro.V.A. Study

Veronese, Nicola; Rui, Marina De; Bolzetta, Francesco; Corti, Maria Chiara; Baggio, Giovannella; Toffanello, Elena Debora; Crepaldi, Gaetano; Perissinotto, Egle; Manzato, Enzo; Sergi, Giuseppe

doi:10.1016/j.jagp.2014.10.009

Cited by 21 publications

(23 citation statements)

References 38 publications

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“…We have observed that DHEA and DHEAS levels are significantly lower in suicide attempters in comparison with non‐attempters. Our findings are consistent with the results of some prospective studies, suggesting an association of lower DHEAS levels with depression . Also, a recent study found that higher DHEAS levels were associated with reduced risk of developing depressive symptoms .…”

Section: Discussionsupporting

confidence: 93%

Dehydroepiandrosterone and dehydroepiandrosterone sulfate levels in combat veterans with or without a history of suicide attempt

Sher

Flory

Bierer

et al. 2018

Acta Psychiatr Scand

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Section: Discussionsupporting

confidence: 93%

Dehydroepiandrosterone and dehydroepiandrosterone sulfate levels in combat veterans with or without a history of suicide attempt

Sher

Flory

Bierer

et al. 2018

Acta Psychiatr Scand

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“…Third, subclinical cerebrovascular disease, low‐grade inflammation and low sexual hormone levels could play a role in the development of both conditions (Vaughan, Corbin and Goveas, ; Veronese et al ., ; Taylor, Aizenstein and Alexopoulos, ). Our data seem to support this hypothesis because the association of pre‐frailty and frailty with depression was strong before the adjustments for potential confounders (pre‐frail had an increased risk of depression of about two times and frail of more than five times compared with robust people).…”

Section: Discussionmentioning

confidence: 99%

Frailty and incident depression in community‐dwelling older people: results from the ELSA study

Veronese

Solmi

Maggi

et al. 2017

Int J Geriat Psychiatry

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“…This suggests a dysregulation of endogenous production of DHEA and DHEAS in the brain in MDD. Indeed, lower DHEA in women during peri‐menopause and lower DHEAS concentration in both elderly men and women in plasma have been found to be related to higher depression symptoms and a higher prevalence of depression, while higher serum DHEAS significantly reduced the risk of developing depressive symptoms . It should be noted though that conflicting findings also exist , possibly due to differences in study design.…”

Section: Discussionmentioning

confidence: 99%

Alterations in the steroid biosynthetic pathways in the human prefrontal cortex in mood disorders: A post‐mortem study

Luchetti

Verwer

et al. 2017

Brain Pathology

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Altered levels of steroids have been reported in the brain, cerebral spinal fluid and plasma of patients with mood disorders. Neuroimaging studies have reported both functional and structural alterations in mood disorders, for instance in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC). In order to determine whether the endogenous production of steroids is altered in the ACC and DLPFC of patients with major depressive disorder (MDD) or bipolar disorder (BPD), quantitative real-time PCR was performed to detect mRNA expression level of key enzymes in the steroid biosynthetic pathways. In MDD, a significant decrease in mRNA level of cytochrome P450 17A1 (CYP17A1, synthesizing C19 ketosteroids) in the ACC and a significant increase in mRNA levels of hydroxysteroid sulfotransferase 2A1 [SULT2A1, catalyzing the sulfate conjugation of dehydroepiandrosterone (DHEA)] were observed in the DLPFC, suggesting alterations in DHEA and its sulfate metabolite DHEAS levels. Decreased intensity and distribution of CYP17A1 immunohistochemical staining was found in the ACC of MDD patients. Interestingly, there was a significant positive correlation between the mRNA levels of CYP17A1 and tyrosine-related kinase B (TrkB) full length isoform. In a unique post-mortem human brain slice culture paradigm, BDNF mRNA expression was found to be significantly increased following incubation with DHEA. Together, these data indicate a close relationship between DHEA and BDNF-TrkB pathways in depression. Furthermore, in the DLPFC, higher mRNA levels of 11β-hydroxysteroid dehydrogenase-1 (HSD11B1, reducing cortisone to the active hormone cortisol) and steroidogenic acute regulatory protein (STAR, facilitating the shuttle of cholesterol through the intermembrane space) were found in the MDD patients and BPD patients, respectively. In conclusion, this study suggests the presence of a disturbance in the endogenous synthesis of DHEA and DHEAS in mood disorders, which has a close relationship with BDNF-TrkB signaling.

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Serum Dehydroepiandrosterone Sulfate and Incident Depression in the Elderly: The Pro.V.A. Study

Cited by 21 publications

References 38 publications

Dehydroepiandrosterone and dehydroepiandrosterone sulfate levels in combat veterans with or without a history of suicide attempt

Dehydroepiandrosterone and dehydroepiandrosterone sulfate levels in combat veterans with or without a history of suicide attempt

Frailty and incident depression in community‐dwelling older people: results from the ELSA study

Alterations in the steroid biosynthetic pathways in the human prefrontal cortex in mood disorders: A post‐mortem study

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