Serum dopamine-beta-hydroxylase in depressed patients and the effect of electroconvulsive shock treatment

Lamprecht, Friedhelm; Ebert, Michael H.; Turek, Ibrahim; Kopin, Irwin J.

doi:10.1007/bf00429418

Cited by 14 publications

(7 citation statements)

References 26 publications

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“…These findings hold good despite changes in clinical state during treatment (6,8,20). Many results confirm the finding that serum DBH activity is virtually identical in monozygotic twins (7,12,17), that serum DBH activity is highly correlated in dizygotic twins (7,12,17) and that serum DBH activity is still significantly correlated in a sibling-sibling relationship (24).…”

supporting

confidence: 77%

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Serum Dopamine-Beta-Hydroxylase in Affective Disorders

Strandman¹,

Wetterberg²,

Perris³

et al. 1978

Neuropsychobiology

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Serum dopamine-β-hydroxylase (DBH) activity was tested in 160 psychiatric patients suffering from affective disorders. The patients were divided into subgroups according to strict diagnostic criteria and clinical state at the time of the examination. Since no relationship was found between DBH activity and age or sex, these variables have been discarded from further analyses. Bipolar (manic-depressive) patients had lower (p < 0.05) DBH mean values than patients suffering from unipolar, recurrent depressive psychoses. No other differences were found either among groups or in relation to the clinical state. As such a wide range of DBH values was recorded in all the groups examined, measurements of DBH activity do not seem to be useful as a diagnostic aid, or as an indicator of the clinical state of patients suffering from affective disorders.

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supporting

confidence: 77%

“…The samples tested for serum DBH activity were taken at different times of the day but earlier investigations have found no significant diurnal variation in either psychiatric or normal populations (6,25). The serum DBH activity was found to react to psychological stress in one paper.…”

Section: Sources O F Errormentioning

confidence: 99%

Serum Dopamine-Beta-Hydroxylase in Affective Disorders

Strandman¹,

Wetterberg²,

Perris³

et al. 1978

Neuropsychobiology

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“…Changes of serum DBH activity were revealed in a number of 'dopaminergic' dis eases: e.g., Parkinson's disease, Huntington's chorea [Liebermann et al, 1972], paranoid schizophrenia [Fujita et al, 1978;Arato et al, 1981b, and tardive dyskinesia [Jeste et al, 1979;Arato et al, 1980b], Our recent finding appears to be a direct proof of the above correlation: We have observed a sig nificant negative relationship between the se rum DBH activity and the levels of dopa mine and of its metabolites in the cerebrospi nal fluid [Aratd et al, in press]. Only a few contradictory data are known according to which ECT does not influence [ Wetterberg et al, 1972;Eshel et al, 1978] or produces a rise in serum DBH activity [Lamprecht et al, 1974],…”

Section: Introductionmentioning

confidence: 72%

“…Lamprecht et al [1974] found a slight increase of serum DBH activity in the blood samples taken 5 min after ECT. Eshel et al [1978] observed no change compared to the baseline during 30-150 min following ECT.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine Study of the Mechanism of Action of Electroconvulsive Therapy

Arató¹,

Bagdy²

1982

Neuropsychobiology

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The authors’ earlier studies indicated that prolactin (PRL) response to electroconvulsive therapy (ECT) was not the result of stress reaction, because the secretion of other stress-sensitive hormones showed no parallel increase. The results of the present investigation are consistent with this findings as diazepam pretreatment failed to influence the PRL response induced by ECT. The rise of the serum PRL level was accompanied by a slight but significant decrease of the serum dopamine-β-hydroxylase activity. A significant negative correlation was found between baseline serum dopamine-β-hydroxylase activity and PRL response. These data indicate a correlation between serum dopamine-β-hydroxylase activity and central dopaminergic function. PRL response to ECT is supposed to be the result of the dopaminergic action of ECT.

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“…With regard to hypertension, several reports have demonstrated elevated serum DBH among patients with labile or essential hypertension (11)(12)(13) while other investigations show no such relationship (6,14,15). With regard to depression, separate groups of investigators (13,16,17) have reported independently that there is no difference in serum DBH activity between depressed patients and controls. Recently Meltzer et al (18) reported significantly reduced serum DBH activity among unipolar psychotic depressives and a nonsignificant trend toward reduced DBH activity among bipolar psychotic depressives as compared with controls; these investigators also found that DBH activity among nonpsychotic and neurotic depressives was slightly (but nonsignificantly) elevated.…”

Section: Introductionmentioning

confidence: 93%

Depression, Hypertension, and Serum Dopamine-β-Hydroxylase Activity

Friedman¹,

Stolk²

1978

Psychosomatic Medicine

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Serum dopamine-beta-hydroxylase (DBH) activity was measured in a heterogeneous sample of 290 outpatients awaiting medical, surgical, or psychiatric appointments at a Veterans Administration Hospital. All patients were assessed for depressive symptomatology by the Zung Self-Rating Depression Scale (SDS) and for elevated diastolic blood pressure (BP greater than or equal to 90 mm Hg). Elevated DBH activity was associated with SDS scores greater than or equal to 60. No statistical association was found between DBH activity and diastolic BP. Two pharmacological agents, alpha-methyl-DOPA and minor tranquilizers, also were associated with significant alterations in serum DBH activity.

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Serum dopamine-beta-hydroxylase in depressed patients and the effect of electroconvulsive shock treatment

Cited by 14 publications

References 26 publications

Serum Dopamine-Beta-Hydroxylase in Affective Disorders

Serum Dopamine-Beta-Hydroxylase in Affective Disorders

Neuroendocrine Study of the Mechanism of Action of Electroconvulsive Therapy

Depression, Hypertension, and Serum Dopamine-β-Hydroxylase Activity

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