Serum dopamine-?-hydroxylase in psychiatric patients and normals. Effect of d-amphetamine and haloperidol

Markianos, Manolis; Nyström, Irene; Reichel, Hans; Matussek, N.

doi:10.1007/bf00426842

Cited by 42 publications

(10 citation statements)

References 18 publications

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“…The relationship between DBH activity and neuroleptic therapeutic response was studied by several investigators. Markianos et al [1976] found that, compared to controls, a higher proportion of schizophrenic patients present increased serum DBH activity that was insensitive to the inhibitory effect of haloperidol. In contrast, other investigators [Sternberg et al, 1982; Van Kammen et al, 1983] showed that schizophrenic patients with low CSF levels of DBH exhibited more acute psychotic symptoms and appeared to be more responsive to standard antipsychotic medications.…”

Section: Discussionmentioning

confidence: 96%

Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study

Yamamoto

Cubells

Gelernter

et al. 2002

American J of Med Genetics Pt B

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Recently, two polymorphisms (DBH5'-Ins/del and DBH 444 g/a) of the Dopamine Beta Hydroxylase (DBH) gene were isolated, and one haplotype (Del-a) was found to be associated with low DBH activity and cocaine-induced paranoia. The purpose of this study is to test for association between these two polymorphisms and schizophrenia or its phenotypic variability with respect to neuroleptic therapeutic response and symptom profile. Allelic and haplotype distributions of these two polymorphisms were compared between two groups of schizophrenic patients (excellent neuroleptic-responders; R, n = 42 and non-responders; NR, n = 64), and one group of healthy volunteers (n = 120). The "Del" and "a" alleles were in positive linkage disequilibrium. No allelic or genotype differences in the distribution of these two polymorphisms were observed between patients and controls. However, The Del-a haplotype was significantly more common in NR patients, and the mean total BPRS score was significantly higher in the group of patients with the Del-a compared to those without the Del-a haplotype. These results suggest that the DBH gene is not a causative factor in schizophrenia but that it may be a modulator of psychotic symptoms, severity of the disorder and therapeutic response to neuroleptic drugs.

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Section: Discussionmentioning

confidence: 96%

Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study

Yamamoto

Cubells

Gelernter

et al. 2002

American J of Med Genetics Pt B

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“…It has long been proposed that DBH activity alters in patients with mental illness, especially those with affective disorder or schizophrenia, although the findings to data have been inconsistent (Wise and Stein 1973;Wyatt et al 1975;Markianos et al 1976;Melter et al 1976;Fujita et al 1978;van Kammen et al 1983;Wei et al 1992). DBH deficiency has also been reported in some neurological or physical diseases in humans (Biaggioni et al 1990).…”

Section: Discussionmentioning

confidence: 99%

Possible control of dopamine β-hydroxylase via a codominant mechanism associated with the polymorphic (GT) n repeat at its gene locus in healthy individuals

Wei¹,

Ramchand²,

Hemmings³

1996

Human Genetics

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Six allelic fragments were typed by a PCR-based process with a pair of primers specific for a sequence containing the polymorphic (GT)n repeat at the human dopamine beta-hydroxylase (DBH) locus in 125 unrelated healthy individuals. Their frequencies among these individuals were 0.012 (A1), 0.08 (A2), 0.344 (A3), 0.548 (A4), 0.004 (A5) and 0.012 (A6); the two major alleles, A3 and A4, made up nearly 90% of the alleles. These individuals were divided into four groups according to the genotype they possessed, i.e. A3/A3, A4/A4, A3/A4 and others (mixed group). Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among these four genetic groups (H = 32.7, P < 0.0001). The homozygotic genotypes, A3/A3 and A4/A4, were associated with low and high DBH activity, respectively, and the heterozygotic genotype, A3/A4, seemed to play a role in keeping the DBH activity at a moderate level. The present work suggests that the human DBH is likely to be controlled via a codominant mechanism associated with the dinucleotide repeat polymorphism at its gene locus.

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“…The difference between this study and our data might be explained by the fact that our study included larger groups of war veterans, and that plasma DBH activity was higher in subjects carrying CC genotype of the DBH −1021C/T polymorphism, which was not assessed in the Hamner and Gould (1998) study. Aside from different genotypes, lower plasma DBH activity might be affected by previous medication, as exposure to neuroleptics decreases plasma DBH activity (Markianos et al, 1976). Since our subjects were medication‐free, the possible effect of neuroleptics on plasma DBH activity was excluded.…”

mentioning

confidence: 99%

Dopamine beta‐hydroxylase (DBH) activity and ‐1021C/T polymorphism of DBH gene in combat‐related post‐traumatic stress disorder

Mustapić

Pivac

Kozarić‐Kovačić

et al. 2007

American J of Med Genetics Pt B

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The roles of dopamine (DA) and norepinephrine (NE) in posttraumatic stress disorder (PTSD) are unclear. The aim of the study was to determine plasma dopamine beta-hydroxylase (DBH) activity and DBH-1021C/T gene polymorphism in combat veterans with (N = 133) or without (N = 34) chronic PTSD. Similar frequencies in genotype or allele distribution were found between veterans with or without PTSD. War veterans with PTSD had lower DBH activity, associated with the DBH-1021C/T variant in DBH genes, than veterans without PTSD. A significantly lower plasma DBH activity was found in combat veterans with PTSD carrying the CC genotype as compared to veterans without PTSD carrying the corresponding genotype. Since both groups were exposed to the same trauma, it is possible that a pre-existing trait difference in regulation of NE function contributed to a differential vulnerability to develop PTSD, or that the regulation of DBH expression was different in response to trauma. The results suggest that that genotype-controlled measurement of plasma DBH activity might be used as a potential biological marker of the response to trauma, and that further studies of DBH and other loci related to DA and NA in PTSD are warranted.

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Serum dopamine-?-hydroxylase in psychiatric patients and normals. Effect of d-amphetamine and haloperidol

Cited by 42 publications

References 18 publications

Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study

Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study

Possible control of dopamine β-hydroxylase via a codominant mechanism associated with the polymorphic (GT) n repeat at its gene locus in healthy individuals

Dopamine beta‐hydroxylase (DBH) activity and ‐1021C/T polymorphism of DBH gene in combat‐related post‐traumatic stress disorder

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