Serum Electrolyte Levels (Sodium and Potassium) in Cerebrovascular Accidents at a Tertiary Care Hospital - A Case Control Study

Nemade, Surekha Tushar; Patil, Mrunal; Chaudhari, Rajendra A.; Vankudre, Ashok J.

doi:10.18311/mvpjms/2015/v2/i1/789

Cited by 1 publication

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“…A previous study also suggested that serum hypokalemia lowers the extracellular potassium level, which may induce cellular membrane depolarization and calcium ion influx, leading to ischemia and neural injury [7]. Furthermore, one study reported that owing to electrolyte disturbance, the accumulation of metabolites such as arachidonic and lactic acids could aggravate brain edema and consequently damage the brain parenchyma [14]. Another study suggested that hypokalemia is associated with a high mortality rate due to stroke regardless of age and hypertension history [7].…”

Section: Discussionmentioning

confidence: 99%

“…The neurological recovery that occurs in the first few days to several weeks after stroke onset is determined by the recovery of the ischemic penumbra and the resolution of edema and associated mass effects [13]. Hypokalemia may cause vasoconstriction, neural injury, and brain edema, which may be an inhibitory factor of neurologic recovery in patients with stroke [7,14]. One study proposed 2 hypotheses regarding the mechanism underlying serum hypokalemia in patients with stroke [7].…”

Section: Discussionmentioning

confidence: 99%

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Significance of Hypokalemia in Functional Outcomes of Patients with Subacute Stroke

Kim

Park

et al. 2019

Brain Neurorehabil

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This retrospective case-control study aimed to the effect of hypokalemia on the functional outcomes of patients with subacute stroke. A total of 96 post-stroke hemiplegic patients admitted to an inpatient clinic of the department of rehabilitation medicine between March 2014 and February 2018 were recruited. Serum potassium level was assessed at the time of admission, and the patients with hypokalemia on admission or within 7 days after onset were classified into the hypokalemic group. Functional assessments using the Hemispheric Stroke Scale (HSS), Functional Ambulation Category (FAC), Functional Independence Measure for locomotion, and Mini Mental Status Examination were performed. The primary outcome was the change in functional score during rehabilitation. No significant intergroup differences in baseline characteristics were found except hospital stay duration and use of diuretics. FAC recovery (0.91 vs. 1.66, p = 0.001), HSS lower extremity and total motor scores (0.37 vs. 1.10, p = 0.01; 0.83 vs. 2.18, p = 0.02, respectively) were significantly lower in the hypokalemic group. Pearson correlation analysis of the initial serum potassium level and functional recovery revealed significant correlations with the FAC or HSS lower extremity and total motor scores (p = 0.001, p = 0.01, and p = 0.04, respectively).

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Section: Discussionmentioning

confidence: 99%