1973
DOI: 10.1001/jama.1973.03230130024009
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Serum Enzyme Alterations in Neuromuscular Disorders

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Cited by 111 publications
(31 citation statements)
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“…While the CK has the most pronounced elevation, and hence greatest sensitivity,6 other serum enzymes (ALT, AST, LDH, and aldolase) are elevated to lesser degrees in most degenerative muscle diseases. Munsat et a1.7 7 published the mean percent increase above normal of CK and ALT (SGPT) in a number of muscle diseases at their initial presentation. In the Duchenne's type of muscular dystrophy, the mean ALT (SGPT) is 925 percent above normal and the elevation of CK is 4.8 times the elevation of the ALT (SGPT).…”
Section: Discussionmentioning
confidence: 99%
“…While the CK has the most pronounced elevation, and hence greatest sensitivity,6 other serum enzymes (ALT, AST, LDH, and aldolase) are elevated to lesser degrees in most degenerative muscle diseases. Munsat et a1.7 7 published the mean percent increase above normal of CK and ALT (SGPT) in a number of muscle diseases at their initial presentation. In the Duchenne's type of muscular dystrophy, the mean ALT (SGPT) is 925 percent above normal and the elevation of CK is 4.8 times the elevation of the ALT (SGPT).…”
Section: Discussionmentioning
confidence: 99%
“…Further tests were performed on a variable number of subjects: needle EMG examination (100/114), basal (54/114), post-ischemic forearm (37/114), and post-exercise (34/114) blood lactate tests [24], urine aminoacid and organic tests (39/114), in vitro contracture test (13/114).All individuals underwent open muscle biopsy; the specimens were examined with routine histological and histochemical methods (hematoxilin and eosin, modified Gomori trichrome, cytochrome c oxidase, succinate dehydrogenase, NADH dehydrogenase, adenosine triphosphatase at pH 9.4, 4.6, 4.3, acid phosphatase, periodic-acid Schiff, oil red O) along with reactions for myoadenylate deaminase, myophosphorylase and phosphofructokinase [8] and immunohistochemistry with antibodies against dystrophin and sarcoglycans [31].…”
Section: Clinical and Laboratory Evaluationmentioning
confidence: 99%
“…[18] However, literatures that describe and compare the muscle components in this disorder are few. In D/BMD, absence or truncation of dystrophin component leads to disruption of myocyte organization caused by genetic defects in the machinery of it, which in turn leads to progressive fiber damage and degeneration of muscle fibers;[19] it is thought to be a key molecular event in the pathology.…”
Section: Introductionmentioning
confidence: 99%