Serum enzyme half life can be a useful factor for follow-up management of biliary pancreatitis

Choi, Jae Young; Kang, Nam Lyong; Choi, Sang Don

doi:10.1016/j.clinbiochem.2009.01.003

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…The average half-lives of amylase and lipase were longer in initial biliary pancreatitis, while the average peak values were higher in the post-ERCP pancreatitis. This shows the importance of the levels of amylase, lipase, and bilirubins in biliary pancreatitis and also the half-lives of amylase and lipase [13]. …”

Section: Discussionmentioning

confidence: 99%

The Predictivity of Serum Biochemical Markers in Acute Biliary Pancreatitis

Güngör

Çağlayan

Polat

et al. 2011

ISRN Gastroenterology

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Background and Aim. There are no accurate methods of differentiating acute biliary pancreatitis. Obstructions of biliary ducts, idiopathic pancreatitis may be related with biliary origin which needs identification for acute treatment. We searched for the predictivity of biochemical markers in early acute biliary pancreatitis. Patients and Methods. Serum levels of AST (Aspartate Transaminase),ALT (Alanine Transaminase), ALP (Alkaline Phosphatase), GGT (Gamma Glutamyl Transferase), total bilirubin, direct bilirubin, LDH (Lactate Dehydrogenase), amylase, lipase, CRP (C-Reactive Protein) and WBC (White Blood Cell) were measured in 157 patients with acute pancreatitis. Biliary and nonbiliary pancreatitis were differentiated by Magnetic Resonance Cholangiopancreatography (MRCP), Endoscopic Retrograde Cholangiopancreatography (ERCP), Intraoperative Cholangiopancreatography (IOC). Cut-off points of admission biochemical markers with sensitivity, specifity, positive predictive value and negative predictive value were determined after identification of significant variables. Receiver Operator Curves were plotted for each biochemical marker. Results. Serum Alkaline Phosphatase, total bilirubin, direct bilirubin, amylase and lipase levels were significantly higher in biliary pancreatitis with a positive predictive value of 80.8%, 83.9%, 81.6%, 78.8%, 79.7%. Conclusion. Increased Alkaline Phosphatase,total bilirubin, direct bilirubin, amylase and lipase levels may be used in prediction of biliary pancreatitis.

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Section: Discussionmentioning

confidence: 99%

The Predictivity of Serum Biochemical Markers in Acute Biliary Pancreatitis

Güngör

Çağlayan

Polat

et al. 2011

ISRN Gastroenterology

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“…Although this study was excluded as it measured lipase following intervention, Choi et al ., investigating lipase in biliary pancreatitis, concluded that lipase downtrends following removal of biliary obstruction was predictive of relaxation of the biliary system and moreover led to improvement in clinical outcome, which may suggest a benefit of lipase monitoring in the biliary pancreatitis subgroup …”

Section: Discussionmentioning

confidence: 99%

“…Although this study was excluded as it measured lipase following intervention, Choi et al, investigating lipase in biliary pancreatitis, concluded that lipase downtrends following removal of biliary obstruction was predictive of relaxation of the biliary system and moreover led to improvement in clinical outcome, which may suggest a benefit of lipase monitoring in the biliary pancreatitis subgroup. 19 Regarding the subgroup of traumatic pancreatitis, data is even more limited: two retrospective studies identified explored the utility of serial lipase measurement in the traumatic pancreatitis affecting the paediatric population. 6,9 Herman et al conducted a large multicentre trial evaluating paediatric patients with traumatic pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Serial lipase for pancreatitis: not enough evidence

Pathmarajah

Idrees

Nasim

et al. 2017

ANZ Journal of Surgery

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The evidence supporting or opposing serial lipase as a prognostic factor for pancreatitis is weak and consists mainly of retrospective analyses. The only prospective data identified suggested benefits to serial lipase in prognosis. Further prospective studies evaluating the prognostic value of serial lipase in the adult population with both traumatic and non-traumatic pancreatitis are required given the paucity of available evidence.

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Serum enzyme half life can be a useful factor for follow-up management of biliary pancreatitis

Cited by 2 publications

References 15 publications

The Predictivity of Serum Biochemical Markers in Acute Biliary Pancreatitis

The Predictivity of Serum Biochemical Markers in Acute Biliary Pancreatitis

Serial lipase for pancreatitis: not enough evidence

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