Serum Enzymes in Hepatobiliary Carcinoma

Sharma, Priyanka; Gupta, Mili; Goyal, Gitanjali; Kaur, Kiranjit

doi:10.14260/jemds/2014/2132

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…Therefore, liver function can be evaluated by assessing the activities of serum ALT, AST, ALP, and bilirubin. In addition, according to Sharma et al [60], the increase in serum level of ALP is due to its increase synthesis in the presence of increasing biliary pressure and reflects the pathological modification in biliary flow. In addition, verification of serum bilirubin also signifies an index for evaluation of hepatic function wherein any unusual increase in the levels of serum bilirubin point towards hepatobiliary-related ailments and severe disruption of hepatocellular function [61].…”

Section: Discussionmentioning

confidence: 99%

Aqueous Partition of Methanolic Extract of Dicranopteris linearis Leaves Protects against Liver Damage Induced by Paracetamol

et al. 2019

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This study aimed to determine the antioxidant and hepatoprotective activities of semi-purified aqueous partition obtained from the methanol extract of Dicranopteris linearis (AQDL) leaves against paracetamol (PCM)-induced liver intoxication in rats. The test solutions, AQDL (50, 250, and 500 mg/kg), were administered orally to rats (n = 6) once daily for seven consecutive days followed by the hepatotoxicity induction using 3 g/kg PCM (p.o.). Blood was collected for serum biochemical parameters analysis while the liver was collected for histopathological examination and endogenous antioxidant enzymes analysis. AQDL was also subjected to antioxidant determination and phytochemical analysis. Results obtained show that AQDL possessed high total phenolic content (TPC) value and remarkable radical scavenging activities. AQDL also significantly (p < 0.05) reduced the liver weight/body weight (LW/BW) ratio or serum level of ALT, AST, and total bilirubin while significantly (p < 0.05) increase the level of superoxide dismutase (SOD) and catalase (CAT) without affecting the malondialdehyde (MDA) in the liver indicating its hepatoprotective effect. Phytoconstituents analyses showed only the presence of saponins and triterpenes, but lack of flavonoids. In conclusion, AQDL exerts hepatoprotective activity via its high antioxidant potential and ability to modulate the endogenous enzymatic antioxidant defense system possibly via the synergistic action of saponins and triterpenes.

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Section: Discussionmentioning

confidence: 99%