Serum Epidemiological Trial on the Prevalence of the Anti-Cytomegalovirus Antibodies in Patients under Substitutive Treatment with Hemodialysis and CAPD

Spisni, C; Stingone, A; Vito, Roberto Di; Rondinella, I.; D’Amario, Claudio; Tucci, Enrico; Caravelli, L.; D’Angelo, Barbara; Cerasoli, Pier Tito

doi:10.1159/000186950

Cited by 6 publications

(6 citation statements)

References 2 publications

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“…[ 16 ] There are several published articles on seroprevalence of CMV among hemodialysis patients in Europe in 1990s. The prevalence of CMV antibodies in this population is reported to be 67% in Italy,[ 17 ]80% in the Czech Republic,[ 18 ] 83% in Germany[ 19 ] and 99.3% in Serbia. [ 20 ] A study conducted in the Netherlands in 2007 showed a seroprevalence rate of 68.7% among Dutch patients.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and dynamics of cytomegalovirus infection among patients undergoing chronic hemodialysis

Vilibić-Čavlek¹,

Kolarić²,

Ljubin‐Sternak³

et al. 2015

Indian J Nephrol

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Cytomegalovirus (CMV) is an important pathogen in immunocompromised individuals. The aim of this study was to analyze prevalence and dynamics of CMV infection among patients undergoing chronic hemodialysis. From 2010 to 2012, a total of 162 patients and 160 control subjects were tested for the presence of CMV IgM and IgG antibodies using enzyme-linked immunosorbent assay. IgM/IgG reactive samples were further evaluated for IgG avidity to confirm or rule out recent primary CMV infection. The overall IgG seropositivity was higher in hemodialysis patients compared to controls (90.7% vs. 81.9%; crude odds ratio [OR] =2.02, 95% confidence interval [CI] =1.05–3.89; OR adjusted for age and gender = 2.18, 95% CI = 1.05–4.55). CMV IgG antibody titers were similar in both groups. There was no difference in CMV prevalence between males (87.9%) and females (96.3%). According to age, a progressive increase in seropositivity was observed in both hemodialysis patients and the control group. Three hemodialysis patients (1.9%) developed recurrent CMV infection (positive IgM with high avidity IgG antibodies). In one patient (2.9%), seroconversion was documented during the second year of the follow-up period indicating primary infection. In contrast, in the control group, recent primary CMV infection (positive IgM with low/borderline IgG avidity) was demonstrated in three subjects (1.9%), whereas one (0.6%) developed recurrent infection. On multivariate logistic regression, hemodialysis and older age were significant predictors for CMV seropositivity.

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Section: Discussionmentioning

confidence: 99%

“…Age-related increase in the seroprevalence of CMV antibodies has also been shown in some other studies. [ 12 13 14 15 16 17 18 19 20 21 22 23 24 25 ]…”

Section: Discussionmentioning

confidence: 99%

Prevalence and dynamics of cytomegalovirus infection among patients undergoing chronic hemodialysis

Vilibić-Čavlek¹,

Kolarić²,

Ljubin‐Sternak³

et al. 2015

Indian J Nephrol

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“…Interestingly, all the other 4 patients had their liver enzymes elevated around the time of their peak GMTs of IgG to either CMV or EBV. Although virus isolation was not done at that time, this temporal relationship warrants further work‐up for CMV and EBV infections when liver function deteriorates in hemodialysis patients, especially those without hepatitis B or C (9).…”

Section: Discussionmentioning

confidence: 99%

A Two Year Follow‐Up Study of Common Virus Infections in Hemodialysis Patients in Taiwan

et al. 2002

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The study was designed to determine whether hemodialysis patients in Taiwan had a different antibody response to common virus infections compared to the normal population. Serum samples from 18 hemodialysis patients and 21 healthy volunteers were obtained every 3 months for 2 years. Geometric mean titers (GMTs) of immunoglobulin G (IgG) antibodies to cytomegalovirus (CMV), herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), as well as Type A and Type B influenza viruses (Inf. A, Inf. B) were compared between the patient and the control groups. The prevalence rates and the rates of recurrent infection were similar in both groups. However, the patient group had a higher percentage of persons having persistent EBV and CMV infections (p < 0.05) and also higher GMTs of antibodies nearly the whole year round, especially significant in September and December (p < 0.05). In patients with hepatitis C, their GMTs of EBV, VZV, Inf. A, and Inf. B were higher than those without (p < 0.05).

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“…It is considered as an opportunistic infection in hemodialysis patients. The prevalence of antibodies specific for CMV in adults undergoing hemodialysis ranged from 67% up to 100% in different geographical areas [16][17][18][19][20][21][22][23][24]. In one Egyptian study, the seroprevalencewas 98%for CMV-IgG and 11% for CMV-IgM [9].…”

Section: Discussionmentioning

confidence: 99%

Molecular Study of Cytomegalovirus Infection among Children with End Stage Renal Diseases Undergoing Dialysis, Pilot Study

2017

Medical &Amp; Clinical Research

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Cytomegalovirus is considered as an opportunistic infection affecting immunocompromized patients. Children with end stage renal diseases requiring dialysis is among affected population by this virus. The aim of the present study was to detect and compare the seroprevalence of CMV and CMV antigen pp65 with real time polymerase chain reaction (PCR) among children with end stage renal diseases undergoing dialysis. The study is a prospective case - control study. The forty one patients included in the studied are registered in the hospital for regular dialysis waiting for renal transplantation. The study included forty one healthy controls with same age and gender distribution. Blood samples were obtained from studied children and subjected for determination of specific immunoglobulin M and G for CMV (IgM-CMV, IgG-CMV) by Elecys system and CMV-DNA determination by real time polymerase chain reaction (PCR) and for PP65 antigenaemia test by light diagnostic CMVpp65. CMV-IgM was significantly detected frequently (P=0.0001) in 12.2% of the patients and in 2.4% of the control children. Moreover, IgG-CMV was significantly more frequently detected in patients (P=0.0001) than in control (90.2%&31.7% respectively). CMV-DNA was significantly (P=0.0001) detected in 12 patients (29.3%) compared to the control (2.4%), while CMVpp65 was detected among 4 children (9.8%) compared to one child in the control group. The comparison between IgM-CMV and real time PCR revealed that 30.7% of positive samples by PCR had positive IgMCMV, while IgG-CMV was associated with 84.6% of positive PCR. CMVpp65 correctly identified all negative samples compared to PCR, while the majority of negative PCR was also negative for IgM-CMV (98.6%). Moreover, all negative children for CMVpp65 was also negative by PCR (100%) For the validity of different CMV markers, IgG-CMV was the most sensitive test (84.7%), CMVpp65 was the most specific test 100%. From this study we concluded that CMV is a common viral infection among children with end stage renal diseases requiring dialysis. The diagnostic performance of real time PCR is the gold standard technique in diagnosis of this infection. CMVpp65 antigenemia is a specific accurate test for laboratory diagnosis however, it lacks sensitivity. Specific IgG for CMV is good screening diagnostic test.

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Serum Epidemiological Trial on the Prevalence of the Anti-Cytomegalovirus Antibodies in Patients under Substitutive Treatment with Hemodialysis and CAPD

Cited by 6 publications

References 2 publications

Prevalence and dynamics of cytomegalovirus infection among patients undergoing chronic hemodialysis

Prevalence and dynamics of cytomegalovirus infection among patients undergoing chronic hemodialysis

A Two Year Follow‐Up Study of Common Virus Infections in Hemodialysis Patients in Taiwan

Molecular Study of Cytomegalovirus Infection among Children with End Stage Renal Diseases Undergoing Dialysis, Pilot Study

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