Serum Erythropoietin and Aging: A Longitudinal Analysis

Ershler, William B.; Shan, Sheng; McKelvey, Julie; Artz, Andrew S.; Denduluri, Neelima; Tecson, Josephine; Taub, Dennis D.; Brant, Larry J.; Ferrucci, Luigi; Longo, Dan L.

doi:10.1111/j.1532-5415.2005.53416.x

Cited by 143 publications

(93 citation statements)

References 24 publications

(43 reference statements)

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“…15,20,21) However, it has already been concluded that RDW predicts poor long-term outcome regardless of anemia status in AHF patients. 14,22,23) We observed that RDW was associated with low hemoglobin and depressed MCV, which are consistent with a state of impaired iron mobilization.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Prognostic Value of Red Cell Distribution Width and NT-proBNP for Short-Term Clinical Outcomes in Acute Heart Failure Patients

Jia

Chen

et al. 2014

Int. Heart J.

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SummaryComparison of the prognostic value of red cell distribution width (RDW) and N-terminal pro B-type natriuretic peptide (NT-proBNP) for short-term clinical outcomes in acute heart failure (AHF) patients has not been fully investigated.A total of 128 patients with AHF were enrolled and followed for 3 months. Primary endpoints were cardiovascular (CV) events, defi ned as cardiac death and/or readmission for HF. Baseline RDW and NT-proBNP were measured at admission.The 30-day and 90-day CV event rates were 16.4% and 35.9%, respectively. NT-proBNP was higher in people with cardiovascular events at both time points, while RDW was signifi cantly higher only at the 90-day time point. The area under the ROC curve of RDW (area under the ROC curve = 0.695) for the prediction of CV events was higher than that of NT-proBNP (area under the ROC curve = 0.610) at the 90-day time point, but lower at the 30-day time point. Cox hazard analysis revealed RDW and NT-proBNP were independent predictive factors of a 90-day CV event (RDW, hazard ratio, 4.610, 95% confi dence interval 1.935-10.981, P = 0.001; NT-proBNP, hazard ratio, 3.661, 95% confi dence interval 1.125-11.907, P = 0.031). Kaplan-Meier survival analysis revealed that patients with an RDW level > 14.5% and NT-proBNP > 1471.5 pg/mL were at highest risk for a CV event (P < 0.001).RDW and NT-proBNP are strong independent predictors of 90-day cardiovascular events in patients hospitalized with AHF. RDW can add prognostic value to NT-proBNP for predicting early cardiovascular events. (Int Heart J 2014; 55: 58-64) Key words: Marker, Prognosis A cute heart failure (AHF) has been defi ned as new-onset or gradual or rapidly worsening heart failure signs and symptoms requiring urgent therapy. 1) It is the leading cause of hospitalization in adults over 65 years.2) AHF may result from new onset of ventricular dysfunction or, more typically, exacerbation of chronic heart failure symptoms. 3)Recognizing such higher risk patients, however, may be challenging. Although numerous parameters indicate the prognosis of heart failure, most are costly to evaluate and are assessed only in research.4) Red cell distribution width (RDW) is a measure of the variability in size of circulating erythrocytes. 5)This parameter is a widely investigated and routine laboratory value reported as a component of complete blood count.A previous study has shown RDW can be a significant independent predictor of all-cause mortality and hospital readmission for patients with chronic heart failure (CHF).6) It was also found to be an independent and addictive predictor of early mortality in patients with acute dyspnea. 7) Higher levels of RDW correlate to poorer survival in stroke, 8) myocardial infarction 9) and pulmonary hypertension. 10) However, little is known about the prognostic value of RDW in the short-term outcome in acute heart failure. Accordingly, in order to determine the prognostic utility of RDW in short-term adverse outcome in patients with AHF, we conducted a prospective study to compare RDW ...

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Section: Discussionmentioning

confidence: 99%

Comparison of Prognostic Value of Red Cell Distribution Width and NT-proBNP for Short-Term Clinical Outcomes in Acute Heart Failure Patients

Jia

Chen

et al. 2014

Int. Heart J.

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“…Accordingly, since RDW level indicates abnormal red blood cell survival but it correlates also with the presence of severe systemic inflammatory state, undernutrition and inadequate production of EPO (3,25), this parameter has been investigated as prognostic factor and marker of disease activity in hematological malignancies [i.e., lymphocytic and myeloid leukemia, multiple myeloma, lymphoma and myelodysplastic syndrome (MDS)] (26)(27)(28)(29)(30)(31)(32)(33).…”

Section: Role Of Rdw In Hematological Tumorsmentioning

confidence: 99%

Red cell distribution width and cancer

2016

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Red cell distribution width (RDW) is an index which primarily reflects impaired erythropoiesis and abnormal red blood cell survival. In last years the interest in this marker has considerably grown and now a lot of data are available indicating that this simple and inexpensive parameter is a strong and independent risk factor for death in the general population. Moreover, several investigations have been performed to investigate the role of RDW in cardiovascular and thrombotic disorders. Contrarily, there are relatively few reports focusing on RDW in the area of oncology and to date none review have been performed in this specific field. As such, the aim of this narrative review is to summarize some interesting results obtained in studies performed in patients affected by solid and hematological tumors. Even if larger studies are needed before these preliminary findings can be generalized, it seems plausible to affirm that RDW can be useful by adding prognostic information in patients with oncologic disease.

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“…[18][19][20] Although some of these cases might result from myelodysplastic syndrome, Guralnik and colleagues estimated that at least one-quarter of the anemia cases in older adults would remain unexplained. 18 While erythropoietin levels have been shown to increase with aging, 8 suggesting that decreased bone marrow response or red cell survival contributes to anemia in older adults, Ferrucci and colleagues demonstrated that erythropoietin levels and pro-inflammatory cytokines were significantly lower in older Italian adults with unexplained anemia compared to non-anemic persons. 20 The genetic contribution to unexplained anemia in older adults has not been defined.…”

mentioning

confidence: 99%

“…An average decline of 0.06 g/dL per year was observed in one prospective study of adults who did not have anemia or chronic kidney disease at baseline. 8 In addition to decreasing levels with older age, variation in the distribution of hemoglobin concentration increases with age as well. To illustrate, Figure 2 shows that average hemoglobin level decreases but variance increases with each successive age group in men, although this pattern is less clear in women it did occur after the reproductive age period (>50 years).…”

mentioning

confidence: 99%

Variability and heritability of hemoglobin concentration: an opportunity to improve understanding of anemia in older adults

Patel¹

2008

Haematologica

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Serum Erythropoietin and Aging: A Longitudinal Analysis

Cited by 143 publications

References 24 publications

Comparison of Prognostic Value of Red Cell Distribution Width and NT-proBNP for Short-Term Clinical Outcomes in Acute Heart Failure Patients

Comparison of Prognostic Value of Red Cell Distribution Width and NT-proBNP for Short-Term Clinical Outcomes in Acute Heart Failure Patients

Red cell distribution width and cancer

Variability and heritability of hemoglobin concentration: an opportunity to improve understanding of anemia in older adults

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