Serum Erythropoietin Levels are Inappropriately Low in the Acute Neuropsychiatric Porphyrias

Abstract

watmm ?he most d e d sgk upregulation was with chnic aldmtemne watment and was greatest in medullary collecting duct Dunng development sgk is expmyxl in atissue specific manna (mainly @tissues coexpressing ENaC) and is upregulated in cohwskmid responsive tssues (ludney, lung and liver) at bith, again suggesting g l m r t i c o i d mimalowriicoid regulation. In contnrst o b 2 is not upregulated in adult kidney following aldostemne treatment and did not show a developmental expression paitem suggesting corticosteroid regulation but was expressed at high levels throughout development.These finding support sgk (but not c-laas-2) as a gene transcribed in mediating the action of aldosterone in kidney and so as a candidate gene coniibuting to the aetiology of hyptemion, Our 6ndmg.s during development also indicate the @way for cortioostaoid regulated sodium absorption seems intact before b& in kidney colon and lung and is upregulated mnatally. The sgk tissue distribution also indicates roles beyond mineralocorticoid action and epithelial sodiumtmnsport 27 PLASMA LIPOPROTEIN (a) LEVELS ARE HIGHER IN PATIENTS WITH CHRONIC RENAL FAILURE UNDERGOING DIALYSIS BUT LOWER IN POST RENAL TRANSPLANTATION