Serum FAM19A5 levels: A novel biomarker for neuroinflammation and neurodegeneration in major depressive disorder

Han, Kook Nam; Tae, Woo Suk; Kim, Aram; Kang, Yu Ri; Kang, Wooyoung; Kang, June; Kim, Yong Ku; Kim, Bongcheol; Seong, Jae Young; Ham, Byung Joo

doi:10.1016/j.bbi.2020.03.021

Cited by 34 publications

(39 citation statements)

References 65 publications

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“…Recently, FAM19A5 has been found to be associated with a variety of diseases and disorders. Han and his colleagues explore the significance of a novel chemokine-like peptide (FAM19A5), which was associated with the presence of depressive symptoms and might be a biomarker of neuroinflammation and neurodegeneration for major depressive disorder [23]. In addition, researchers from Korea University confirmed that serum FAM19A5 may be a novel biomarker for cardiovascular metabolic diseases, which was significantly correlated to various human metabolic and vascular risk factors [9].…”

Section: Discussionmentioning

confidence: 99%

Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia

Song

et al. 2020

Disease Markers

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Objective. Family with sequence similarity 19 member A5 (FAM19A5), a novel chemokine-like peptide, is a secreted protein mainly expressed in the brain. FAM19A5 was recently found to be involved in a variety of neurological diseases; however, its correlation with vascular dementia (VaD) remains unclear. The aim of the study is to explore the association between serum FAM19A5 and cognitive impairment in subjects with VaD. Method. 136 VaD subjects and 81 normal controls were recruited in the study. Their demographic and clinical baseline data were collected on admission. All subjects received Mini-Mental State Examination (MMSE) evaluation, which was used to test their cognitive functions. A sandwich enzyme-linked immunosorbent assay (ELISA) was applied to detect the serum levels of FAM19A5. Results. No significant differences were found between the two groups regarding the demographic and clinical baseline data (p>0.05). The serum FAM19A5 levels were significantly higher compared to normal controls (p<0.001). The Spearman correlation analysis indicated that serum FAM19A5 levels and MMSE scores have a significant negative correlation in VaD patients (r=−0.414, <0.001). Further multiple regression analysis indicated that serum FAM19A5 levels were independent risk predictors for cognitive functions in VaD (β=0.419, p=0.031). Conclusion. The serum FAM19A5 level of VaD patients is significantly increased, which may serve as a biomarker to predict cognitive function of VaD.

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Section: Discussionmentioning

confidence: 99%

Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia

Song

et al. 2020

Disease Markers

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“…39 The cortical thickness was determined by calculating the distance between the pia mater and white matter surface using the surface deformation algorithm. 40 We inspected cortical reconstructions for the automatic segmentation of gray and white matter boundaries, and data with inaccuracies were discarded. Smoothing of the cortical map was performed using a Gaussian kernel with a full width at half maximum of 20 mm for all cortex analyses.…”

Section: Image Processingmentioning

confidence: 99%

“…Detailed information about the protocol of procedures in the FreeSurfer have been described in our previous publications. [39][40][41][42] We also measured total in-tracranial cavity volume (TICV) manually based on previous literature, 43 and TICV was used as a covariate in the analysis.…”

Section: Image Processingmentioning

confidence: 99%

Association of Prefrontal Cortex Thinning with High Impulsivity in Healthy Adults

Lim

Kim

Seo

et al. 2021

Psychiatry Investig

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Objective Studies have been conducted to identify brain structural alterations related to high impulsivity in psychiatric populations. However, research on healthy subjects is relatively less extensive. Therefore, we aimed to investigate the correlation between the cortical thickness of whole brain regions and the impulsivity level in a healthy population. Methods We included 100 healthy participants aged 19-65 years. Their T1-weighted magnetic resonance images and the 23-item Barratt Impulsiveness Scale (BIS) score were obtained. The patients were divided into high and low impulsivity groups according to the 75th percentile score of the BIS in the sample. The thickness of each cortical region was calculated using the FreeSurfer, and the difference in cortical thickness of the whole brain between the high and low impulsivity groups was analyzed using one-way analysis of covariance including age, sex, education level, and total intracranial cavity volume as covariates. Results The high impulsivity group showed significant cortical thinning in the left pars opercularis. The cortical thickness of the left pars opercularis significantly correlated negatively with the total, attention, and motor scores of the BIS scale. Conclusion Our findings suggest that prefrontal cortex thinning may play an important role in the development of high impulsivity in healthy adults.

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“…Wang et al showed FAM19A5 inhibits the vascular smooth muscle cells proliferation and ameliorates neointima formation in the injured rat carotid arteries (8). Although several studies addressed contribution of FAM19A5 to neurological disorders (19)(20)(21)(22)(23), existing data on a relevant association of FAM19A5 and cardiac and metabolic disorders are very limited (8,9). To our knowledge, this is the first clinical observation pointing to the association of FAM19A5 with the pathogenesis of NAFLD.…”

Section: Introductionmentioning

confidence: 80%

“…Several studies have shown association of FAM19A5 gene with neurological and/or psychiatric diseases (19-22, 25, 26). FAM19A5 has been linked to in ammation, differentiation and cognition (19,21,23,26,27). But few studies have addressed the role of FAM19A5 in cardiometabolic disorders.…”

Section: Discussionmentioning

confidence: 99%

Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease

Yari

Shabani

Karami

et al. 2020

Preprint

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Background: Family with sequence similarity 19 (chemokine (C-C motif)-like) member A5 (FAM19A5) is a newly identified adipokine. There is a limited number of studies linking FAM19A5 to metabolic disorders. In the current study, we aimed to explore if FAM19A5 is associated with nonalcoholic fatty liver disease (NAFLD). We also sought to determine the possibility of FAM19A5 association with subclinical atherosclerosis in NAFLD patients. Methods: A total of 69 subjects including 37 NAFLD and 32 control subjects were included in this cross-sectional study. Plasma concentration of FAM19A5 was measured with the ELISA method. Carotid artery intima-media thickness (cIMT) was assessed by the ultrasonography.Results: Plasma concentration of FAM19A5 in patients with NAFLD was significantly lower in NAFLD patients than controls. Moreover, we observed significant negative correlations between plasma level of FAM19A5 and body mass index (BMI), visceral fat, alanine amino transferase (ALT), aspartate amino transferase (AST), liver stiffness (LS), and cIMT. Following stepwise multiple linear regression analysis, ALT and cIMT were the only determinants of FAM19A5 level. Conclusions: This is the first report to describe association of circulating FAM19A5 levels with NAFLD. Our findings provide further evidence showing relation of FAM19A5 with the risk of atherosclerosis. However, more studies are necessary to unravel the contribution of lower FAM19A5 levels to the NAFLD pathogenesis and the higher risk of atherosclerosis in these patients.

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Serum FAM19A5 levels: A novel biomarker for neuroinflammation and neurodegeneration in major depressive disorder

Cited by 34 publications

References 65 publications

Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia

Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia

Association of Prefrontal Cortex Thinning with High Impulsivity in Healthy Adults

Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease

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