Serum Fatty Acid Binding Protein 4 Is an Early Marker for Acute Myocardial Infarction

Ohyama, Yoshiaki; Iso, Tatsuya; Masuda, Kuniko; Tamura, Shuntaro; Murata, Makoto; Iijima, Takafumi; Goto, Kosaku; Funada, Ryuichi; Koitabashi, Norimichi; Takama, Noriaki; Arai, M.; Kurabayashi, Masahiko

doi:10.1016/s0735-1097(13)60192-8

Cited by 2 publications

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“…This finding was unexpected as FABP4 is considered as a pro-inflammatory adipocytokine (Rodríguez-Calvo et al, 2017). Studies have shown that increased FABP4 plasma levels predict development of metabolic syndrome and type 2 diabetes mellitus, as well as cardiovascular events in patients with peripheral arterial disease (Xu et al, 2007;Ohyama et al, 2013;Höbaus et al, 2018;Rodríguez-Calvo et al, 2017). Clinical data and the findings from a FABP4-null mouse study confirmed the role of FABP4 as a key factor involved in the development of obesity-related pathologies in humans (Xu et al, 2007).…”

Section: Discussionmentioning

confidence: 90%

“…FABP4 is a member of the lipid chaperone family and regulates the intracellular transport of fatty acids (Rodríguez-Calvo et al, 2017). Prospective trials have shown that FABP4 plasma level is associated with the development of metabolic syndrome and type 2 diabetes mellitus and predicts cardiovascular events (Xu et al, 2007;Ohyama et al, 2013;Rodríguez-Calvo et al, 2017;Höbaus et al, 2018). In addition, plasma level of FABP4 is related to elevated cardiovascular mortality in male patients with type 2 diabetes mellitus (Xu et al, 2007;Rodríguez-Calvo et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

et al. 2021

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Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

et al. 2021

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“…FABP4 играет важную роль в регуляции процессов воспаления и метаболизма липидов, а также чувствительности к инсулину [4]. У лиц с ожирением, МС и СД2 наблюдается повышенный уровень FABP4 в сыворотке крови [2,[7][8][9][10]. Исследование [11] показало, что FABP4 связывается в кровотоке с ферментами нуклеозиддифосфаткиназой (NDPK) и аденозинкиназой (ADK), образуя белковый комплекс «фабкин» (FABP4-ADK-NDPK, Fabkin).…”

Section: Introductionunclassified

<i>FABP4</i> gene expression in subcutaneous and visceral adipose tissue in patients with obesity and type 2 diabetes mellitus

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Pobozheva

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et al. 2022

The Scientific Notes of the Pavlov university

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Introduction. Obesity is associated with a high risk of developing concomitant diseases such as: metabolic syndrome, type 2 diabetes mellitus (DM2), cardiovascular pathology. FABP4 (fatty acid binding protein) is the specific lipid chaperone and an important protein for the function of adipose tissue and is one of the adipocytokines secreted by adipose tissue.The objective of the study was to investigate the FABP4 gene expression in subcutaneous and visceral adipose tissue (SAT and VAT) in patients with obesity and DM2.Methods and materials. SAT and VAT samples were obtained during bariatric surgery (N=43, BMI>35): obese with DM2 (N=21), obese without DM2 (N=22). Samples for the control group without obesity (N=15, BMI<30) were obtained during planned operations on the abdominal cavity. FABP4 mRNA level was estimated by real-time PCR.Results. It has been demonstrated that the mRNA level of the FABP4 gene in SAT and VAT is reduced in obesity, regardless of the manifestation of DM2 (p<0.01). A negative correlation was observed between the mRNA level of the FABP4 gene in adipose tissue and the BMI index (for SAT: r=—0.327, p = 0.016; for VAT: r=—0.304, p = 0.024).Conclusion. The expression level of FABP4 gene in AT can act as a marker of AT dysfunction in obesity.

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Serum Fatty Acid Binding Protein 4 Is an Early Marker for Acute Myocardial Infarction

Cited by 2 publications

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FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

<i>FABP4</i> gene expression in subcutaneous and visceral adipose tissue in patients with obesity and type 2 diabetes mellitus

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