Serum fatty acid-binding protein 4 levels and responses of pancreatic islet β-cells and α-cells in patients with type 2 diabetes

Wang, Hong; Cao, Jie J; Su, Jianbin; Wang, Xueqin; Wang, Xing; Zhang, Dongmei; Wang, Xiaohua

doi:10.1186/s13098-021-00690-z

“…FABP4 and fatty acids promote and regulate insulin secretion during obesity [36,37]. Moreover, FABP4 has been correlated with C-peptide [37], which denotes endogenous insulin production [38]. Our results confirmed the association of FABP4 and C-peptide levels.…”

Section: Discussionsupporting

confidence: 82%

“…Apart from BMI, FABP4 has been associated with other markers and risk factors for adiposity, for example, triglycerides, leptin, and cholesterol levels [26,[33][34][35]. FABP4 and fatty acids promote and regulate insulin secretion during obesity [36,37]. Moreover, FABP4 has been correlated with C-peptide [37], which denotes endogenous insulin production [38].…”

Section: Discussionmentioning

confidence: 99%

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes

Vorobjova,

Tagoma,

Talja

et al. 2022

Journal of Diabetes Research

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Objectives. Gestational diabetes mellitus (GDM) is glucose intolerance detected initially during pregnancy. GDM poses an increased risk for the development of diabetes later in life. Fatty acid-binding protein 4 (FABP4) is a regulator of lipid metabolism and is associated with obesity, insulin resistance, and type 2 diabetes. Increased level of intestinal fatty acid-binding protein (I-FABP) may indicate impaired intestinal permeability, which may be an important contributor to the pathogenesis of type 1 diabetes and GDM. We aimed to compare FABP4 and I-FABP levels in pregnant women with GDM and in healthy pregnant controls, taking into consideration their prepregnancy body mass index (BMI), past exposures to enteroviruses (EV), and adipokine and cytokine levels, which have been shown to decrease insulin sensitivity. Material and Methods. Forty patients with GDM (median age 30.5) and 40 pregnant healthy controls (median age 31.1) were divided on the basis of their prepregnancy BMI into two groups: normal weight ( BMI < 25 , n = 20 ) and overweight ( BMI ≥ 25 , n = 20 ). FABP4 and I-FABP were measured from serum samples using commercial ELISA kits. Results. FABP4 and I-FABP levels did not differ between women with GDM and healthy pregnant controls ( p > 0.05 for both comparisons). However, both levels were associated with BMI ( p < 0.001 for both comparisons). Median I-FABP level was the highest in healthy controls with lower BMI (<25) ( p = 0.0009 ). FABP4 levels correlated with BMI and C-peptide values in both groups ( p < 0.001 ). Anti-EV antibody levels did not correlate with FABP4 or I-FABP levels. FABP4 and adiponectin levels were negatively correlated in controls ( r = − 0.61 , p = 0.0009 ), while I-FABP correlated positively with adiponectin ( r = 0.58 , p = 0.04 ) and resistin ( r = 0.67 , p = 0.04 ) levels in the GDM group. Conclusion. FABP4 and I-FABP levels were not dependent on the diagnosis of GDM, but rather on BMI. The correlation of I-FABP with adiponectin and resistin levels in women with GDM may suggests the importance of lipid metabolism in GDM-associated changes in intestinal permeability.

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“… 29 Increased serum FABP4 levels were found to be closely associated with insulin resistance and elevated fasting and post-challenge glucagon levels in T2DM. 30 In this study, we also found that the baseline level of FABP4 was higher in participants with AGM than in those with NGT, and the baseline level of FABP4 was positively correlated with age, BMI, WC, 2hBG, TG, TC and LDL at the 2-year follow-up. Furthermore, we found that high baseline FABP4 [OR 0.960, 95% CI (0.928–0.993)] was not conducive to reversion from prediabetes to NGT.…”

Section: Discussionsupporting

confidence: 71%

High Serum FABP4 Levels are Negatively Associated with the Reversion from Prediabetes to Normal Glucose Tolerance: A 2-Year Retrospective Cohort Community Study

Gu¹,

Lin²,

Gai³

et al. 2022

DMSO

0

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Objective To explore the relationship between the level of fatty acid-binding protein 4 (FABP4) and reversion from prediabetes to normal glucose tolerance (NGT). Methods A two-year retrospective cohort study was conducted on 398 participants with complete information. These 398 participants were divided into an NGT group and an abnormal glucose metabolism (AGM) group after 2 years of follow-up. The baseline level of FABP4 was determined, and the role of FABP4 in predicting reversion from prediabetes to NGT was investigated using an unconditional logistic regression model. Results Over the two-year follow-up period, 37.4% (149/398) of the participants reverted from prediabetes to NGT. The participants with AGM had a higher baseline level of FABP4 than those with NGT. The baseline level of FABP4 was significantly negatively correlated with reversion from prediabetes to NGT. After adjusting for age, sex, body mass index and waist-to-hip ratio, the level of fasting blood glucose (FBG) [odds ratio (OR) 0.336, 95% confidence interval (CI) (0.196–0.576)], 2-h post-challenge blood glucose (2hBG) [OR 0.697, 95% CI (0.581–0.837)], and FABP4 [OR 0.960, 95% CI (0.928–0.993)] at baseline were significant independent predictors of reversion from prediabetes to NGT. The area under the curve (AUC) value of the receiver operating characteristic curve for FABP4 was 0.605 (95% CI: 0.546–0.665), and the AUC for FABP4 combined with FBG and 2hBG was 0.716 (95% CI: 0.663–0.769). Conclusion A higher baseline level of FABP4 was positively correlated with an adverse profile of diabetes risk factors and negatively correlated with reversion from prediabetes to NGT. FABP4, FBG and 2hBG were predictors of reversion from prediabetes to NGT.

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“…In addition, increased CysC concentration may induce an inflammatory response by enhancing TNF-α expression ( 30 , 49 ), and inflammation may in turn lead to β-cell dedifferentiation ( 50 , 51 , 52 ), characterized by loss of β-cell identity and expression of glucagon in these β-cells ( 53 ). Moreover, our previous study has demonstrated that fatty acid-binding protein 4, an inflammatory factor primarily originated from adipose tissue, was positively associated with fasting and postprandial glucagon levels in T2D ( 54 ). Collectively, our present study and the relevant literatures indicated that increased serum CysC levels may be contributed to the elevated fasting and postprandial glucagon in patients with T2D.…”

Section: Discussionmentioning

confidence: 99%

Increased serum cystatin C levels and responses of pancreatic α- and β-cells in type 2 diabetes

Yuan

¹

,

Miao

²

,

Xu

³

et al. 2022

Endocrine Connections

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Background: Increased serum cystatin C (CysC) can predict the onset of type 2 diabetes (T2D). Meanwhile, impaired pancreatic α- and β-cell functions get involved in the pathophysiological processes of T2D. So this study was to explore the relationships between serum CysC levels and pancreatic α- and β-cell functions in T2D. Methods: In this cross-sectional observational study, total 2634 patients with T2D were consecutively recruited. Each recruited patient was received serum CysC test and oral glucose tolerance test for synchronous detection of serum C-peptide and plasma glucagon. As components of pancreatic β-cell function, insulin secretion and sensitivity indices were evaluated by C-peptide area under curve(AUC-CP) and C-peptide-substituted Matsuda’s index(Matsuda-CP), respectively. Fasting glucagon(F-GLA) and post-challenge glucagon calculated by glucagon area under curve(AUC-GLA) were used to assess pancreatic α-cell function. These indices were skewed and were further natural log-transformed(ln). Results: With quartiles of serum CysC levels ascending, AUC-CP, F-GLA and AUC-GLA were increased, while Matsuda-CP was decreased(p for trend<0.001). Moreover, serum CysC levels were positively related to lnAUC-CP, lnF-GLA and lnAUC-GLA (r=0.241, 0.131 and 0.208, respectively, p<0.001), and inversely related to lnMatsuda-CP(r= –0.195, p<0.001). Furthermore, after controlling for other relevant variables via multivariable linear regression analysis, serum CysC levels were identified to account for lnAUC-CP (β=0.178, t=10.518, p<0.001), lnMatsuda-CP (β= –0.137, t= –7.118, p<0.001), lnF-GLA (β=0.049, t=2.263, p=0.024) and lnAUC-GLA (β=0.121, t=5.730, p<0.001). Conclusions: Increased serum CysC levels may be partly responsible for increased insulin secretion from β-cells, decreased systemic insulin sensitivity, and elevated fasting and postprandial glucagon secretion from α-cells in T2D.

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Serum fatty acid-binding protein 4 levels and responses of pancreatic islet β-cells and α-cells in patients with type 2 diabetes

Cited by 11 publications

References 50 publications

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes

High Serum FABP4 Levels are Negatively Associated with the Reversion from Prediabetes to Normal Glucose Tolerance: A 2-Year Retrospective Cohort Community Study

Increased serum cystatin C levels and responses of pancreatic α- and β-cells in type 2 diabetes

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