Serum fatty acid patterns in patients with schizophrenia: a targeted metabonomics study

Yang, Xuhan; Sun, Liya; Zhao, Aihua; Hu, Xiaowen; Qing, Ying; Jiang, Jie; Yang, Chao; Xu, Tian‐Le; Wang, P; Liu, J; Zhang, J; He, Lin; Jia, Weiping; Wan, Chunling

doi:10.1038/tp.2017.152

Cited by 54 publications

(28 citation statements)

References 54 publications

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“…In fact, our team have revealed a phenomenon of elevated free fatty acids and ketone bodies in SZ patients’ serum in a metabolomic study 47 and later a validating lipidomic study. 48 We proposed for increased lipolysis in SZ patients and a transfer of energy substance to the brain for energy supply. Such an increased consumption of free fatty acids in SZ might additionally contribute to the reduced level of membrane fatty acids.…”

Section: Discussionmentioning

confidence: 99%

Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population

Sun

Yang

Jiang

et al. 2017

Schizophrenia Bulletin

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Schizophrenia (SZ) is a devastating mental disease caused by complex genetic and environmental factors. The pathological process and clinical manifestation of SZ are heterogeneous among patients, which hampers precise diagnosis and treatment of the disease. Since no objective marker for SZ has been established today, to identify a subgroup of the patients with homogeneous biochemical traits will provide a new angle for both researchers and clinicians to understand and manage the disease. In this study, we employed the niacin skin-flushing test in Chinese population and confirmed a niacin-blunted subgroup of SZ patients distinguishable from mood disorders (MD) and normal individuals. This subgroup accounted for 30.67% of the total SZ patients with a specificity of 88.37% in male subjects and 83.75% in female subjects. We support the notion that bluntness in niacin skin test might reflect abnormalities in membrane fatty acid composition, which could be induced by increased PLA2 enzyme activity, in vivo oxidative stress or lipid metabolism imbalance in SZ. Further studies are encouraged to clarify the molecular origins of niacin-bluntness in SZ, which would provide extra clues for etiological research in schizophrenia and for new targeted treatment.

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Section: Discussionmentioning

confidence: 99%

Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population

Sun

Yang

Jiang

et al. 2017

Schizophrenia Bulletin

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“…DHA and EPA are structurally integrated via phospholipid molecules and they ensure the proper structure of neuronal cell membranes [3]. FAs regulate the expression of genes, as well as changes in protein concentration, which could be blocked to some extent in SZ patients [36].…”

Section: Discussionmentioning

confidence: 99%

The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia

et al. 2020

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A growing body of evidence confirms abnormal fatty acid (FAs) metabolism in the pathophysiology of schizophrenia. Omega-3 polyunsaturated fatty acids (PUFAs) are endogenous ligands of the G protein-coupled receptors, which have anti-inflammatory properties and are a therapeutic target in many diseases. No clinical studies are concerned with the role of the GPR120 signaling pathway in schizophrenia. The aim of the study was to determine the differences in PUFA nutritional status and metabolism between patients with schizophrenia (SZ group) and healthy individuals (HC group). The study included 80 participants (40 in the SZ group, 40 in the HC group). There were no differences in serum GPR120 and PUFA concentrations and PUFA intake between the examined groups. In the HC group, there was a relationship between FAs in serum and GPR120 concentration (p < 0.05): α-linolenic acid (ALA) (R = −0.46), docosahexaenoic acid (DHA) (R = −0.54), omega-3 PUFAs (R = −0.41), arachidonic acid (AA) (R = −0.44). In the SZ group, FA serum concentration was not related to GPR120 (p > 0.05). In the HC group, ALA and DHA serum concentrations were independently associated with GPR120 (p < 0.05) in the model adjusted for eicosapentaenoic acid (EPA) and accounted for 38.59% of GPR120 variability (p < 0.05). Our results indicate different metabolisms of FAs in schizophrenia. It is possible that the diminished anti-inflammatory response could be a component connecting GPR120 insensitivity with schizophrenia.

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“…First, reduced total FFA levels may imply an increased regeneration of cell membranes and possible alterations in beta-oxidations of fatty acid metabolism at the early course of SZ. While plenty of studies have focused on the PUFA levels in SZ ( Van der Kemp et al, 2012 ), few have discussed other FAs and the total FA levels in SZ ( McEvoy et al, 2013 ; Yang et al, 2017 ). Recently, a decreased total plasma FFA levels was detected in FEANS patients with limited sample sizes ( Zhou et al, 2017 , 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, previous studies showed that several fatty acid beta-oxidation enzymes were significantly increased in the brains of SZ patients, which implied enhanced beta-oxidation in FEANS patients ( Prabakaran et al, 2004 ). Up-regulated beta-oxidation in peripheral tissues of SZ patient has also been suggested by comparing product-to-precursor ratios of serum FFAs ( Yang et al, 2017 ). The decreased FFAs levels thus may result from a depleted source in membrane phospholipids as lipids metabolism was shifted toward beta-oxidation in the cytosol.…”

Section: Discussionmentioning

confidence: 99%

Reduced Levels and Disrupted Biosynthesis Pathways of Plasma Free Fatty Acids in First-Episode Antipsychotic-Naïve Schizophrenia Patients

et al. 2020

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Membrane phospholipid deficits have been well-documented in schizophrenia (SZ) patients. Free fatty acids (FFAs) partially come from the hydrolysis of membrane phospholipids and serve as the circulating pool of body fatty acids. These FFAs are involved in many important biochemical reactions such as membrane regeneration, oxidation, and prostaglandin production which may have important implications in SZ pathology. Thus, we compared plasma FFA levels and profiles among healthy controls (HCs), affective psychosis (AP) patients, and first-episode antipsychoticnaïve schizophrenia (FEANS) patients. A significant reduction of total FFAs levels was observed in SZ patients. Specifically, significant reductions of 16:0, 18:2n6c, and 20:4n6 levels were detected in FEANS patients but not in APs when compared with levels in HCs. Also, disrupted metabolism of fatty acids especially in saturated and n-6 fatty acid families were observed by comparing correlations between precursor and product fatty acid levels within each fatty acid family. These findings may suggest an increased demand of membrane regeneration, a homeostatic imbalance of fatty acid biosynthesis pathway and a potential indication of increased beta oxidation. Collectively, these findings could help us better understand the lipid metabolism with regard to SZ pathophysiology.

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Serum fatty acid patterns in patients with schizophrenia: a targeted metabonomics study

Cited by 54 publications

References 54 publications

Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population

Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population

The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia

Reduced Levels and Disrupted Biosynthesis Pathways of Plasma Free Fatty Acids in First-Episode Antipsychotic-Naïve Schizophrenia Patients

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