Serum fatty acid profile in subjects with irritable bowel syndrome

Solakivi, Tiina; Kaukinen, Katri; Kunnas, Tarja; Lehtimäki, Terho; Mäki, Markku; Nikkari, Seppo T.

doi:10.3109/00365521.2010.533380

Cited by 25 publications

(31 citation statements)

References 24 publications

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“…A recent study indicates a relative deficiency of polyunsaturated long-chain fatty acids (LCFA) in patients with IBS [87], constituting another rationale for supplying n-3 polyunsaturated fatty acid-rich seal oil to this patient population.…”

Section: Therapeutic Trials: Pilot Studies With Seal Oilmentioning

confidence: 99%

Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center

Lied

Lillestøl

Lind

et al. 2011

Scandinavian Journal of Gastroenterology

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Perceived food hypersensitivity is a prevalent, but poorly understood condition. In this review article, we summarize narratively recent literature including results of our 10 years' interdisciplinary research program dealing with such patients. The patients (more than 400) included in our studies were all adults referred to a university hospital because of gastrointestinal complaints self-attributed to food hypersensitivity. Despite extensive examinations, food allergy was seldom diagnosed. The majority of the patients fulfilled the diagnostic criteria for irritable bowel syndrome. In addition, most suffered from several extra-intestinal health complaints and had considerably impaired quality of life. However, psychological factors could explain only approximately 10% of the variance in the patients' symptom severity and 90% of the variance thus remained unexplained. Intolerance to low-digestible carbohydrates was a common problem and abdominal symptoms were replicated by carbohydrate ingestion. A considerable number of patients showed evidence of immune activation by analyses of B-cell activating factor, dendritic cells and "IgE-armed" mast cells. Multiple factors such as immune activation, disturbed intestinal fermentation, enteric dysmotility, post-infectious changes and "local" allergy in the gut as well as psychological disturbances may play a role in the pathophysiology of perceived food hypersensitivity. Hence, our results support the view that management of these patients should be interdisciplinary.

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Section: Therapeutic Trials: Pilot Studies With Seal Oilmentioning

confidence: 99%

Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center

Lied

Lillestøl

Lind

et al. 2011

Scandinavian Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…Intestine is the main place to absorb fatty acids and -3 PUFAs absorption in intestine is limited by a variety of conditions, including the composition of fatty acids in diet, the body itself and existing form of fatty acids. Solakivi et al analyzed the contents and types of PUFAs in serum of 32 patients with irritable bowed syndrome (IBS) and 59 healthy controls and found that the serum DHA content of IBS patients was significantly decreased (Solakivi et al, 2011). These suggested that the absorption capacity of DHA in intestine of IBS patients was changed.…”

Section: Diet Gut Microbiota and Admentioning

confidence: 99%

Alzheimer’s disease and gut microbiota

Wang

Jin

2016

Sci. China Life Sci.

300

188

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“…A retrospective review of capsule endoscopies for suspected small bowel bleeding demonstrated that combination of low-dose aspirin and thienopyridine drugs (ticlopidine and clopidogrel) may exacerbate small bowel injury [7]. Inadequate supply of long-chain fatty acids was found in subjects with IBS [8]. Organic disease had been ruled out and intestinal malabsorption was suggested by the authors although no mechanism behind this is clear at the present time.…”

Section: This Month In Scandinavian Journal Gastroenterologymentioning

confidence: 94%