Serum fatty acids and ischemic stroke subtypes in middle- and late-onset acute stroke patients

Mori, Takahisa; Tanno, Yuhei; Kasakura, Shigen; Yoshioka, Kazuhiro; Nakai, Noriyoshi

doi:10.1016/j.yclnex.2018.09.001

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…Concentrations of palmitic acid (PA), StA, OlA, LiA, and AA were found to be higher, and concentrations of EPA were lower in subjects with CAD than in subjects without CAD, whereas compositions of PA and StA were higher and those of EPA and DHA were lower in subjects with CAD [6]. A previous study also reported that people with higher serum levels of saturated fatty acids, n-9 MUFA, and n-6 PUFAs more frequently experienced lacunar or atherosclerotic stroke during middle age (50 to 74 years old) [7]. Serum FA concentrations and compositions might thus be associated with acute ischaemic stroke (AIS).…”

Section: Introductionmentioning

confidence: 84%

Features of serum fatty acids in acute ischaemic stroke patients aged 50 years or older

Mori

Yoshioka

2020

BMC Cardiovasc Disord

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Background: Serum fatty acid (s-FA) compositions and their correlation with serum lipids (s-LPs) such as total cholesterol (T-CHO) and triglycerides (TG) have been reported in healthy young subjects. However, little is known about such features in acute ischaemic stroke (AIS). The aim of our study was to investigate s-FA characteristics and their correlation with AIS in elderly patients. Methods: We conducted a cross-sectional study of patients aged 50 years or older who were admitted between September 2015 and March 2017 within 24 h of the first AIS onset. We evaluated concentrations and compositions of s-FAs and their association with s-LPs, age, and ischaemic stroke subtypes, including large-artery atherosclerosis (LAA), small-vessel occlusion (SVO), and cardioembolism (CE) or others. Results: One hundred ninety-one patients met our inclusion criteria. Their average age was 74.4 years, mean T-CHO and median TG were 203.4 and 94.5 mg/dl, respectively, and median or mean concentrations of palmitic acid (PA), oleic acid (OlA), linoleic acid (LiA), and docosahexaenoic acid (DHA) were 680.7, 602.5, 795.2, and 136.9 μg/ml, respectively, with mean compositions of 23.7, 21.3, 27.1, and 4.4%, respectively. PA, OlA, and LiA concentrations were weakly negatively associated with age and positively correlated with TG. In LAA or SVO (LAA_SVO) and CE or others (CE_O), mean age was 71.9 and 77.4 years (p < 0.001), mean T-CHO was 213.9 and 191.2 mg/dl (p < 0.0001), median TG was 106.5 and 88.5 mg/dl (p < 0.01), median PA was 717.2 and 648.4 μg/ml (p < 0.01), median OlA was 638.2 and 567.5 μg/ml (p < 0.01), and median LiA was 844.7 and 728.5 μg/ml (p < 0.01), respectively. DHA composition was weakly positively correlated with age. There were no differences in PA, OlA, LiA, and DHA compositions between LAA_SVO and CE_O. Conclusions: In AIS elderly patients, concentrations, rather than compositions of PA, OlA, and LiA, correlated with age, TG, and ischaemic stroke subtypes. Patients with LAA_SVO were younger and had higher concentrations of PA, OlA, and LiA than those with CE_O. There were no differences in such compositions between LAA_SVO and CE_O.

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Section: Introductionmentioning

confidence: 84%

Features of serum fatty acids in acute ischaemic stroke patients aged 50 years or older

Mori

Yoshioka

2020

BMC Cardiovasc Disord

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“…The bioactive form of lipoxin A4-15-epi-lipoxin A 4 (15-epi LXA 4 ) that promotes resolution of inflammation by inhibiting superoxide generation and polymorphonuclear leukocyte transmigration was found to be higher in embolic when compared to undetermined subtype of stroke [ 78 ]. It was observed that higher levels of SFA and n6 PUFA were associated with lacunar and atherosclerotic stroke, while no relationships regarding the n3 DHA and the subtypes of stroke were observed [ 79 , 80 ]. Higher levels of C14:0 myristic acid were identified in small-vessel subtypes of stroke in comparison to large-vessel and embolic ones, but in other SFAs (C15:0 pentadecanoid acid) its level was lower in small-vessel compared to undetermined type.…”

Section: Discussionmentioning

confidence: 99%

The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients

Kotlęga

Zembroń-Łacny

Gołąb-Janowska

et al. 2020

IJMS

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The study was designed to demonstrate the relationship of free fatty acids (FFAs) and eicosanoids levels with the severity of depressive symptoms in stroke. The ischemic stroke patients (n = 74) were included in the prospective study. The risk of depression was evaluated by the Beck Depression Inventory-II (BDI-II) 7 days and 6 months after the stroke onset. FFAs and inflammatory metabolites were determined by gas chromatography and liquid chromatography. In the acute phase of stroke, BDI-II and FFAs inversely correlated with C13:0 tridecanoic acid, C15:1 cis-10-pentadecanoid acid, C17:1 cis-10- heptadecanoid acid, C18:0 stearic acid, C20:3n6 eicosatrienoic acid, C22:1cis13 docosenoic acid and C22:6n3 docosahexaenoic acid (DHA). DHA level was significantly lower in patients with low vs. high BDI-II score. In the follow-up examination, BDI-II score directly correlated with C16:0 palmitic acid. The changes in BDI-II score during 6-month observation inversely correlated with lipoxin A4 and protectin D1, and directly correlated with 5-oxo-ETE. Importantly, the severity of depressive symptoms was associated with n3 PUFA level. Diet-derived FFAs were observed to potentially affect the inflammatory pathways in pathogenesis of depression in stroke and reduced DHA levels can attenuate depressive symptoms in stroke patients.

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“…The relationship between serum FA levels under fasting conditions and stroke has been reported [8][9][10]. However, few studies have reported on serum FA levels at the onset of ischemic events [11,12], which are typically examined under non-fasting conditions and associated with the dietary intake of TGs. Higher intake of seafood may be associated with higher n-3 PUFA levels, which is likely to reduce the risk of ischemic events.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, the wt % values of EPA and DHA are lower in subjects with CAD than in healthy controls [15]. Interestingly, in patients who experienced lacunar or atherosclerotic stroke between the ages of 50-74 years, the serum concentrations of saturated fatty acids (SFAs), n-9 monounsaturated fatty acid (n-9 MUFA), and n-6 PUFAs are elevated [11,12]. This suggests that the serum concentrations and wt % of FAs are related to the age of acute ischemic disease onset.…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke

et al. 2020

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Dietary triglycerides influence fatty acid (FA) serum concentrations and weight percentages (wt %), which may be associated with the age of onset of acute ischemic stroke (AIS). We investigated the correlations between serum FA levels and proportions at admission and the age of onset of AIS. We evaluated patients with AIS admitted between 2016 and 2019 within 24 h of AIS onset and calculated the correlation coefficients between their ages, serum FA concentrations, and FA wt % values. Multiple linear regression analysis was performed to identify independent FAs indicating AIS age of onset. Furthermore, we estimated the threshold values of independent FAs for age of onset <60 years using receiver operating characteristic curves by logistic regression. A total of 525 patients (median age: 75 years) met the inclusion criteria. The concentration of dihomo-gamma-linolenic acid (DGLA) and wt % of docosahexaenoic acid (DHA) were significant independent variables for age of onset of AIS, and receiver operating characteristic curves for age of onset <60 years showed thresholds of ≥117.7 µmol/L for DGLA and ≤3.7% for DHA. An increased DGLA concentration and decreased DHA wt % were significantly associated with onset of AIS at a younger age.

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Serum fatty acids and ischemic stroke subtypes in middle- and late-onset acute stroke patients

Cited by 6 publications

References 12 publications

Features of serum fatty acids in acute ischaemic stroke patients aged 50 years or older

Features of serum fatty acids in acute ischaemic stroke patients aged 50 years or older

The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients

Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke

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