Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease

Salonen, Jukka T.; Salonen, Riitta; Penttilä, Ilkka; Herranen, J.; Jauhiainen, Matti; Kantola, M.; Lappeteläinen, Raili; Mäenpää, Pekka H.; Alfthan, Georg; Puska, Pekka

doi:10.1016/0002-9149(85)90839-2

Cited by 244 publications

(75 citation statements)

References 16 publications

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“…In several prospective (3)(4)(5) and case-control (6) studies, low serum selenium levels were associated with increased risk of coronary heart disease. However, in other studies, this association could not be confirmed (7)(8)(9)(10). Antioxidant defense is achieved by additive or synergistic action of enzymes and antiox-idant nutrients (11,12).…”

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confidence: 79%

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Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Kardinaal

Kok

Kohlmeier

et al. 1997

American Journal of Epidemiology

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The association between selenium status and risk of acute myocardial infarction was examined in a multicenter case-control study in 10 centers from Europe and Israel in 1991-1992. Selenium in toenails was assessed for 683 nonfatal male cases with first acute myocardial infarction and 729 controls less than 70 years of age. Median toenail selenium content was 0.553 /xg/g for cases and 0.590 jxg/g for controls. After adjustment for age, center, and smoking, the odds ratio for myocardial infarction in the highest quintile of selenium as compared with the lowest was 0.63 (95 percent confidence interval 0.37-1.07, p for trend = 0.08). The observed inverse trend was somewhat stronger when the authors adjusted for vitamin E status (p = 0.05). Analysis stratified for smoking habits showed an inverse association in former smokers (odds ratio for the 75th-25th percentile contrast = 0.63 (95 percent confidence interval 0.43-0.94)), but not in current smokers (odds ratio = 0.97 ( 0.71-1.32)) or in those who had never smoked (odds ratio = 1.55 (0.87-2.76)). Analysis stratified by center showed a significant inverse association between selenium levels and risk of myocardial infarction for Germany (Berlin) only (75th to 25th percentile odds ratio = 0.62 (95 percent confidence interval 0.42-0.91)), which was the center with the lowest selenium levels. It appears that the increased risk of acute myocardial infarction at low levels of selenium intake is largely explained by cigarette smoking; selenium status does not appear to be an important determinant of risk of myocardial infarction at the levels observed in a large part of Europe. Am J Epidemiol 1997;145:373-9. antioxidants; case-control studies; myocardial infarction; selenium Evidence is accumulating that oxidation of low density lipoprotein particles and cytotoxic effects of lipid peroxides enhance the formation of foam cells and atherosclerotic lesions (1, 2). Selenium is part of the enzyme glutathione peroxidase, which plays an important role in the antioxidant defense of the body against the deleterious actions of free radicals and lipid per-

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confidence: 79%

“…The question of whether low selenium status predisposes to cardiovascular disease has been addressed in a number of studies in the past decade (3)(4)(5)(6)(7)(8)(9)(10). In several prospective (3)(4)(5) and case-control (6) studies, low serum selenium levels were associated with increased risk of coronary heart disease.…”

mentioning

confidence: 99%

Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Kardinaal

Kok

Kohlmeier

et al. 1997

American Journal of Epidemiology

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“…1). Previous studies may have failed to detect this because of adequate retinol levels [18][19][20]. Presumably, this was also the case in US Physicians whose retinol lacked any prediction of CHD [13].…”

Section: Vitamin Amentioning

confidence: 97%

Low plasma retinol predicts coronary events in healthy middle-aged men: The PRIME Study

et al. 2010

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a b s t r a c tThe role of plasma retinol and carotenoids in coronary heart disease (CHD) remains unclear. The PRIME Study prospectively evaluated these in France and Northern Ireland in 9758 men aged 50-59 years who were free of CHD at baseline. After five years' follow-up 150 incident cases of CHD (non-fatal myocardial infarction and fatal CHD) were compared with 285 controls matched for age, date of blood collection and study centre. Geometric means of major carotenoids did not differ significantly between cases and controls (P > 0.05), whereas the absolute and lipid-standardized plasma retinol levels were 9% lower in cases than controls in both countries (P < 0.002), without correlation with carotenoids. After adjusting for risk factors, the relative risks (RRs) of CHD in the first four quintiles of retinol distribution in controls (≤601, −683, −760, and −846 g/l) were 2.65 (P = 0.0009), 1.70, 1.03, and 1.12 (all P > 0.05) respectively, relative to the top quintile (retinol ≥846 g/l; linear trend P = 0.0001). The 10th percentile of lipid-standardized retinol (≤544 g/l) predicted an RR of 4.7 (P < 0.001). The risk associated with low retinol was comparable to strong risk factors (e.g. HDL-cholesterol, Interleukin-6) and behaved additively.In conclusion, plasma retinol levels of <601 g/l in a fifth of middle-aged European men place them at an approximately threefold RR of developing CHD. Thus the intake of vitamin A might be too low in middle-aged men. These findings must be confirmed.

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“…Konukoghu D et al [16] also reported that erythrocyte antioxidant GSH-PX was significantly low in AMI patients than controls (P<0.001) Whereas Ferrari et al [17] were not able to determine any changes in GSH-PX enzyme in heart tissue during iscaemia and reperfusion process. Low levels of GSH-PX in IHD may be because of its utilization in free radicals produced by lipid peroxidation [18].…”

Section: Discussionmentioning

confidence: 99%

Study of Serum Selenium and Glutathione Peroxidase in Acute Myocardial Infarction

Harley¹,

Pramanik²,

Vagga³

2011

Int J Med Clin Res

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Abstract-Selenium is a trace element that plays role in antioxidant defense mechanism via selenium dependent glutathione peroxidases (GSH-PX) and selenoproteins. When selenium is lacking, the intima of the arteries is prone to get oxidative damage and involve in development of atherosclerosis. It has been observed in clinical studies that the serum selenium levels in patients with myocardial infarction and with angina pectoris have been significantly lower than that in healthy people. In the present study we found significantly low concentration of serum selenium in acute myocardial infarction (AMI) compared with the age and sex matched healthy controls with p value less than 0.001.

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Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease

Cited by 244 publications

References 16 publications

Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Low plasma retinol predicts coronary events in healthy middle-aged men: The PRIME Study

Study of Serum Selenium and Glutathione Peroxidase in Acute Myocardial Infarction

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